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Low-dose neuroleptic therapy and extrapyramidal side effects in schizophrenia: an effect size analysis

Published online by Cambridge University Press:  16 April 2020

C Barbui  and
B Saraceno
C Barbui
Affiliation:
Laboratory of Epidemiology and Social Psychiatry, ‘Mario Negri’ Institute for Pharmacological Research, Via Eritrea 62, 20157Milan, Italy
B Saraceno
Affiliation:
Laboratory of Epidemiology and Social Psychiatry, ‘Mario Negri’ Institute for Pharmacological Research, Via Eritrea 62, 20157Milan, Italy
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Summary

A meta-analysis of the published literature was performed in order to quantify the efficacy of low-dose neuroleptic therapy in reducing extrapyramidal side effects in schizophrenic patients. A low-dose regimen between 50–100 mg equivalents of chlorpromazine, in comparison to a standard-dose regimen between 200–500 mg reduced extrapyramidal side effects by a 0.30 (±0.12) standard deviation, which is only a limited effect.

Keywords

neurolepticlow doseside effects
Type
Short communications
Information
European Psychiatry , Volume 11 , Issue 8 , 1996 , pp. 412 - 415
Copyright
Copyright © Elsevier, Paris 1996

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