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Long-term efficacy of tianeptine on alcoholic relapses in non-depressed alcoholic patients. Preliminary results

Published online by Cambridge University Press:  16 April 2020

JD Favre ,
H Lôo ,
C Marey  and
B Delalleau
JD Favre
Affiliation:
Hôpital Bégin, Service de Psychiatric, Saint Mandé
H Lôo
Affiliation:
Service Hospitalo-Universitaire de Santé mentale et de Thérapeutique, Hôpital Sainte Anne, Paris
C Marey
Affiliation:
Institut de Recherches Internationales Servier, 6, place des Pléades, 92415Courbevoie, France
B Delalleau*
Affiliation:
Institut de Recherches Internationales Servier, 6, place des Pléades, 92415Courbevoie, France
*
* Correspondence and reprints.
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Summary

Tianeptine, whose main neurochemical action is to increase 5-HT uptake, significantly decreased alcohol consumption in rats. During a tianeptine long-term treatment study, gamma-GT levels in depressed alcoholic patients decreased, suggesting that this medication could be useful in alcoholism. The role of tianeptine in the prevention of alcoholic relapses is being evaluated in a double-blind placebo-controlled study. Two hundred non-depressed patients satisfying DSM III-R criteria for Psychoactive Substance Dependence (alcohol – daily intake greater than 80 g) will enter the study after alcohol withdrawal. A minimum score of three on the Short-Mast Questionnaire, mean cell volume above 98 f1 and/or gamma-GT more than twice the upper normal value are required. Patients are treated as out-patients and surveyed for 9 months. The maintenance of abstinence is estimated through clinical and laboratory assessments. The alcohol intake is evaluated in patients who relapse. Efficacy is determined secondarily using Clinical Global Impressions Scale, Hopkins Symptom Check List and visual analogue scales. Somatic complaints are collected using AMDP-5. Preliminary results are presented.

Keywords

tianeptinealcoholismalcohol relapse and appetence
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 125s - 129s
Copyright
Copyright © Elsevier, Paris 1993

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