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Lithium augmentation in venlafaxine non-responders: an open study

Published online by Cambridge University Press:  16 April 2020

G. Bertschy ,
E. Ragama-Pardos ,
A. Aït-Ameur ,
M. Muscionico ,
S. Favre  and
L. Roth
G. Bertschy*
Affiliation:
Clinic of Adult Psychiatry, Department of Psychiatry, Geneva University, 2, ch. du Petit Bel-Air, Chene-Bourg, 1225Geneva, Switzerland
E. Ragama-Pardos
Affiliation:
Clinic of Adult Psychiatry, Department of Psychiatry, Geneva University, 2, ch. du Petit Bel-Air, Chene-Bourg, 1225Geneva, Switzerland
A. Aït-Ameur
Affiliation:
Clinic of Adult Psychiatry, Department of Psychiatry, Geneva University, 2, ch. du Petit Bel-Air, Chene-Bourg, 1225Geneva, Switzerland
S. Favre
Affiliation:
Clinic of Adult Psychiatry, Department of Psychiatry, Geneva University, 2, ch. du Petit Bel-Air, Chene-Bourg, 1225Geneva, Switzerland
L. Roth
Affiliation:
Clinic of Adult Psychiatry, Department of Psychiatry, Geneva University, 2, ch. du Petit Bel-Air, Chene-Bourg, 1225Geneva, Switzerland
*
*Corresponding author. E-mail address: [email protected] (G. Bertschy).
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Abstract

Thirteen major depressive patients not responding to a 4-week venlafaxine 300 mg treatment were eligible for a 4-week open trial of lithium addition. Two patients had to stop lithium for a possible moderate serotonin syndrome and five patients became responders, including one dramatic response and two semi-rapid responses.

Keywords

VenlafaxineLithiumDepressionResistance
Type
Short communication
Information
European Psychiatry , Volume 18 , Issue 6 , October 2003 , pp. 314 - 317
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

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References

Bauer, M, Dopfmer, S. Lithium augmentation in treatment-resistant depression: meta-analysis of placebo-controlled studies. J Clin Psychopharmacol 1999;19:427-34.CrossRefGoogle ScholarPubMed
Baumann, P, Nil, R, Souche, A, Montaldi, S, Baettig, D, Lambert, S, et al. A double-blind, placebo-controlled study of citalopram with and without lithium in the treatment of therapy-resistant depressive patients: a clinical, pharmacokinetic, and pharmacogenetic investigation. J Clin Psychopharmacol 1996;16:307-14.CrossRefGoogle ScholarPubMed
Bschor, T, Canata, B, Muller-Oerlinghausen, B, Bauer, M. Predictors of response to lithium augmentation in tricyclic antidepressant-resistant depression. J Affect Disord 2001;64:261-5.CrossRefGoogle ScholarPubMed
Burnett, FE, Dinan, TG. Venlafaxine: pharmacology and therapeutic potential in the treatment of depression. Hum Psychopharmacol 1998;13:153-62.3.0.CO;2-S>CrossRefGoogle Scholar
Charney, DS, Berman, RM, Miller, HL. Treatment of depression. 2nd ed. In: Schatzberg, AF, Nemeroff, CB, The American Psychiatric Press textbook of psychopharmacology. Washington (DC): The American Psychiatric Press; 1998. p. 705-31.Google Scholar
de Montigny, C, Cournoyer, G, Morissette, R, Langlois, R, Caille, G. Lithium carbonate addition in tricyclic antidepressant-resistant unipolar depression: correlations with the neurobiologic actions of tricyclic antidepressant drugs and lithium ion on the serotonin system. Arch Gen Psychiatry 1983;40:1327-34.CrossRefGoogle ScholarPubMed
de Montigny, C, Grunberg, F, Mayer, A, Deschenes, JP. Lithium induces rapid relief of depression in tricyclic antidepressant drug non-responders. Br J Psychiatry 1981;138:252-6.CrossRefGoogle ScholarPubMed
de Montigny, C, Silverstone, PH, Debonnel, G, Blier, P, Bakish, D. Venlafaxine in treatment-resistant major depression: a Canadian multicenter, open-label trial. J Clin Psychopharmacol 1999;19:401-6.CrossRefGoogle ScholarPubMed
Gentil, V, Kerr-Correa, F, Moreno, R, D’Arrigo Busnello, E, De Campos, JA, Juruena, MF, et al. Double-blind comparison of venlafaxine and amitriptyline in outpatients with major depression with or without melancholia. J Psychopharmacol 2000;14:61-6.CrossRefGoogle ScholarPubMed
Hegerl, U, Bottlender, R, Gallinat, J, Kuss, HJ, Ackenheil, M, Moller, HJ. The serotonin syndrome scale: first results on validity. Eur Arch Psychiatry Clin Neurosci 1998;248:96-103.CrossRefGoogle ScholarPubMed
Hoencamp, E, Haffmans, J, Dijken, WA, Huijbrechts, IP. Lithium augmentation of venlafaxine: an open-label trial. J Clin Psychopharmacol 2000;20:538-43.CrossRefGoogle Scholar
Katona, CL, Abou-Saleh, MT, Harrison, DA, Nairac, BA, Edwards, DR, Lock, T, et al. Placebo-controlled trial of lithium augmentation of fluoxetine and lofepramine. Br J Psychiatry 1995;166:80-6.CrossRefGoogle ScholarPubMed
Lejoyeux, M, Adès, J, Rouillon, F. Serotonin syndrome: incidence, symptoms and treatment. CNS Drugs 1994;2:132-43.CrossRefGoogle Scholar
Mekler, G, Woggon, B. A case of serotonin syndrome caused by venlafaxine and lithium. Pharmacopsychiatry 1997;30:272-3.CrossRefGoogle ScholarPubMed
Montgomery, SA, Asberg, M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979;134:382-9.CrossRefGoogle ScholarPubMed
Nierenberg, AA, Adler, LA, Peselow, E, Zornberg, G, Rosenthal, M. Trazodone for antidepressant-associated insomnia. Am J Psychiatry 1994;151:1069-72.Google ScholarPubMed
Nierenberg, AA, Feighner, JP, Rudolph, R, Cole, JO, Sullivan, J. Venlafaxine for treatment-resistant unipolar depression. J Clin Psychopharmacol 1994;14:419-23.CrossRefGoogle ScholarPubMed
Ontiveros, A, Fontaine, R, Elie, R. Refractory depression: the addition of lithium to fluoxetine or desipramine. Acta Psychiatr Scand 1991;83:188-92.CrossRefGoogle ScholarPubMed
Perry, P, Alexander, B, Prince, R, Dunner, F. The utility of a single-point dosing protocol for predicting steady-state lithium levels. Br J Psychiatry 1986;148:401-5.CrossRefGoogle ScholarPubMed
Poirier, MF, Boyer, P. Venlafaxine and paroxetine in treatment-resistant depression: double-blind, randomised comparison. Br J Psychiatry 1999;175:12-6.CrossRefGoogle ScholarPubMed
Walter, G, Lyndon, B, Kubb, R. Lithium augmentation of venlafaxine in adolescent major depression. Aust N Z J Psychiatry 1998;32:457-9.CrossRefGoogle ScholarPubMed
Zullino, D, Preisig, M, Baumann, P. Lithium augmentation in venlafaxine-refactory depression. J Clin Psychopharmacol 2001;21:242-3.CrossRefGoogle ScholarPubMed
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