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Investigations of cerebrospinal fluid in Borna disease virus seropositive psychiatric patients

Published online by Cambridge University Press:  16 April 2020

K Bechter ,
S Herzog ,
W Behr  and
R Schüttler
K Bechter
Affiliation:
Universiry of Ulm, Department of Psychiatry II and Department of Psychiatry of the Bezirkskrankenhaus Günzburg, Ludwig-Heilmeyer-Str 2, 89312Günzburg
S Herzog
Affiliation:
lnstitute of Virology, Justus-Liebig-University, Gieβen
W Behr
Affiliation:
Central Laboratory of the Central Clinics, Augsburg, Germany
R Schüttler
Affiliation:
Universiry of Ulm, Department of Psychiatry II and Department of Psychiatry of the Bezirkskrankenhaus Günzburg, Ludwig-Heilmeyer-Str 2, 89312Günzburg
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Summary

Borna disease virus (BDV) appears to cause meningoencephalitis and schizophreniform psychosis in sporadic cases according to earlier cerebrospinal fluid (CSF) inoculation experiments (Rott et al, 1991). However, CSF parameters in BDV seropositive psychiatric patients proved nearly all normal; only the most sensitive CSF/serum index I-BDV for intrathecally produced BDV specific IgG was pathologic in 10.5–29.0% (according to different methodological limits) of patients. An increase in sensitivity was attempted to detect specific IgG in CSF in a part of the cases by concentration. Concentration procedure does not significantly increase methodological bias according to a statistical analysis of the results. Our findings support the hypothesis that BDV may cause or contribute to the pathogenesis of a diagnostically broad pattern of psychiatric syndromes. The occurence of a spectrum of diagnoses is expected from non-specificity of psychiatric symptoms in other infectious diseases of the brain as well as from results in experimental Borna disease (BD) in animals, when a majority of the animals showed rather unspecific symptomatology due to slight, preferentially limbic encephalitis. Slight deficiencies from an earlier BDV infection could explain continuing symptoms in a part of the cases. Recurrences years after infection are well known in experimental and natural BD in animals. It remains open, whether this mechanism could play a more prominent role in a form of “symptomatic” cyclothymia and “symptomatic” schizophrenia, although the results of CSF investigations are more clear in BDV seropositive patients with major psychoses.

Keywords

cerebrospinal fluid antibodiesBorna disease virus
Type
Original article
Information
European Psychiatry , Volume 10 , Issue 5 , 1995 , pp. 250 - 258
Copyright
Copyright © Elsevier, Paris 1995

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References

Ackermann, R, Nekic, M, Jürgens, RLocally synthesized antibodies in cerebrospinal fluid of patients with AIDS. J Neurol 1986; 233: 140–141CrossRefGoogle ScholarPubMed
Amsterdam, JD, Winokur, A, Dyson, Wet al.Borna disease virus: a possible etiologic factor in human affective disorders? Arch Gen Psychiatry 42 1985 1093–1096Google ScholarPubMed
Bauer, K, Kornhuber, JBlood-cerebrospinal fluid barrier in schizophrenic patients. Eur Arch Psychiatr Neurol Sci 1987; 236: 257–259Google ScholarPubMed
Bechter, K, Herzog, S, Fleischer, B, Schüttler, R, Rott, RMagnetic resonance imaging in psychiatric patients with and without serum antibodies against Boma disease. Nervenarzt 1987; 58: 617–624Google Scholar
Bechter, K, Herzog, S, Schüttler, R, Rott, RDie Borna'sche Krankheit — wahrscheinlich auch eine menschliche Krankheit: neue Ergebnisse. In: Saletu, B eds. Biologische Psychiatrie. Stuttgart: Thieme, 1989; 17–21Google Scholar
Bechter, K, Herzog, SÜber Beziehungen der Borna'schen Krankheit zu endogenen Psychosen. In: Kaschka, WP, Aschauer, HN eds. Psychoimmunologie. Stuttgart, New York: Thieme, 1990; 133–141Google Scholar
Bechter, K, Herzog, S, Schüttler, RPossible significance of Borna disease for humans. Neurol Psychiatry Brain Res 1992; 1: 23–29Google Scholar
Bechter, K, Herzog, S, Schüttler, RCase of neurological and behavioral abnormalities: due to Borna disease virus encephalitis?. Psychiatry Res 1992; 42: 193–196CrossRefGoogle ScholarPubMed
Bechter, K, Herzog, S, Schüttler, RBorna disease virus: possible causal agent in psychiatric and neurological disorders in two families. Psychiatry Res 1992; 42: 291–294CrossRefGoogle ScholarPubMed
Bechter, K, Bauer, M, Estler, HC, Herzog, S, Schüttler, R, Rott, RMRI findings in Borna disease virus seropositive psychiatric patients and controls: an extended study. Nervenarzt 1994; 65: 169–174Google Scholar
Bechter, K. Research strategies in “slow” infections in psychiatry. Hist Psychiatry, in pressGoogle Scholar
Beckmann, H, Jakob, HPrenatal disturbances of nerves cell migration in the entorhinal region: a common vulnerability factor in functional psychoses?. J Neur Transm [Gen Sect] 1991; 84: 155–164CrossRefGoogle Scholar
Bode, L, Riegel, S, Ludwig, H, Amsterdam, JD, Lange, W, Koprowski, HBorna disease virus-specific antibodies in patients with HIV infection and with mental disorders. Lancet 1988; 2: 689CrossRefGoogle ScholarPubMed
Bode, L, Riegel, S, Lange, W, Ludwig, HHuman infections with Borna disease virus: seroprevalence in patients with chronic diseases and healthy individuals. J Med Virol 1992; 36: 309–315Google ScholarPubMed
Bogerts, BThe neuropathology of schizophrenia: pathophysiological and neurodevelopmental implications. In: Mednick, SA, Cannon, TD, Barr, CE, Lyon, M eds. Fetal neural development and adult schizophrenia. Cambridge, New York, London: Cambridge University, 1991; 153–173Google Scholar
Bonhoeffer, KDie exogenen Reaktionstypen. Arch Psychiat Nervenkr 1917; 58: 58–70Google Scholar
Buchsbaum, MS, Rieder, ROBiologic heterogeneity and psychiatric research. Arch Gen Psychiatry 1979; 36: 1163–1169CrossRefGoogle Scholar
Carbone, KM, Duchala, CS, Griffin, JW, Kincaid, AL, Narayan, OPathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation. J Virol 1987; 11: 3431–3440CrossRefGoogle Scholar
Conrad, KDie symptomatischen Psychosen. In: Kisker, KP, Meyer, JE, Müller, M, Strömgren, E eds. Psychiatrie der Gegenwart Vol 2 Berlin, Heidelberg, New York: Springer, 1972; 1–70Google Scholar
Cubbitt, B, Oldstone, C, De la Torre, JCSequence and genome organization of Borna disease virus. J Virol 1994; 68: 1382–1396CrossRefGoogle Scholar
Danner, KBorna-virus und Borna-infektionen. Vom Miasma zum Modell. Stuttgart: Enke, 1982Google Scholar
De'La Torre, JC, Carbone, KM, Lipkin, WIMolecular characterization of Borna disease agent. Virology 1990; 179: 853–856CrossRefGoogle Scholar
Denzel, HASpinal fluid changes in patients treated with ataractic drugs. Am J Psychiatry 1959; 116: 545Google Scholar
Felgenhauer, KDifferentiation of the humoral immune response in inflammatory diseases. J Neurol 1982; 228: 223–237CrossRefGoogle ScholarPubMed
Felgenhauer, KDas Konzept der Blut-Liquorschranke und die Bestimmung lokal synthetisiert Antikörper. In: Huffmann, G, Braune, HJ eds. Infektionskrankheiten des Nervensystems. Einhorn: Reinbek, 1991; 20–24Google Scholar
Fu, ZF, Weihe, E, Zheng, JMet al.Differential effects of rabies and Borna disease viruses on immediate-early-and late-response gene expression in brain tissues J Virol 67 1993 6674–6681Google ScholarPubMed
Gross, G, Huber, G, Linz, MThe problem of “symptomatic schizophrenia” and “symptomatic cyclothymia”. Zentralbl Neurol Psychiat 1989; 251: 323–332Google Scholar
Heinig, ADie Bornasche Krankheit der Pferde und Schafe. In: Rohrer, H eds. Handbuch der Virusinfektionen bei Tieren 4 Jena: VEB Fischer, 1969; 83–148Google Scholar
Herzog, S, Rott, RReplication of Borna disease virus in cell cultures. Med Microbiol Immunol 1980; 168: 153–158Google ScholarPubMed
Herzog, S, Frese, K, Rott, RStudies on the genetic control of resistance of black hooded rats to Borna disease. J Gen Virol 1991; 72: 535–540CrossRefGoogle ScholarPubMed
Hiepe, TDie Bedeutung der Liquoruntersuchung für die Neurodiagnostiz bei Pferd und Schaf. Zentralbl Veterinaermed 1960; 7: 152–159CrossRefGoogle Scholar
Huber, GKlinik und Psychopathologie der organischen Psychosen. In: Kisker, KP, Meyer, JE, Müller, M, Strömgren, C eds. Psychiatrie der Gegenwart Bd 2 Berlin, Heidelberg, New York: Springer, 1972; 71–146Google Scholar
Kao, M, Hamir, AN, Rupprecht, CEet al.Detection of antibodies against Borna disease virus in sera and cerebrospinal fluid of horses in the USA Vet Rec 132 1993 241–244CrossRefGoogle ScholarPubMed
Kennedy, PGE, Johnson, RTInfections of the nervous system. London: Butterworths, 1987Google Scholar
Körber, R, Huffmann, GGibt es Encephalitiden ohne entzündliche Liquorveränderungen?Huffmann, G, Braune, HJInfektionskrankheiten des Nervensystems Reinbek: Einhorn, 1991; 262–266Google Scholar
Kurstak, EIntroductionKurstak, EPsychiatry and biological factors New York: Plenum, 1991; 1–5CrossRefGoogle Scholar
Lange, H, Herzog, S, Herbst, W, Schliesser, TSeroepidemiologische Untersuchungen zur Borna'schen Krankheit Ansteckende Gehirn-Rückenmarksentzündung) der Pferde. Tierärzt Umsch 1987; 42(12): 938–9346Google Scholar
Libikova, HSchizophrenia and viruses: principles of etiologic studies Morozov, PVAdvances in Biological Psychiatry 12 Basel: Karger, 1983; 20–51CrossRefGoogle Scholar
Lipkin, WJ, Travis, GH, Carbone, KM, Wilson, MCIsolation and characterization of Borna disease agent cDNA clones Proc Natl Sci (USA) 87 1990; 4184–4188CrossRefGoogle ScholarPubMed
Lubahn, DB, Silverman, LMA rapid silver-stain procedure for use with routine electrophoresis of cerebrospinal fluid on agarose gel. Clin Chem 1984; 10: 1689–1691CrossRefGoogle Scholar
Ludwig, H, Koester, V, Pauli, G, Rott, RThe cerebrospinal fluid of rabbits infected with Borna disease virus. Arch Virol 1977; 55: 209–223CrossRefGoogle ScholarPubMed
Ludwig, H, Thein, PDemonstration of specific antibodies in the central nervous system of horses naturally infected with Borna disease virus. Med Microbiol Immunol 1977; 163: 215–226CrossRefGoogle ScholarPubMed
Lüer, W, Poser, S, Weber, TChronic HIV Encephalitis-I. Cerebrospinal fluid diagnosis. Klin Wochenschr 1988; 66: 21–25CrossRefGoogle ScholarPubMed
Morales, JA, Herzog, S, Kompter, C, Frese, K, Rott, RAxonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats. Med Microbiol Immunol 1988; 177: 51–68Google ScholarPubMed
Müller, N, Ackenheil, N, Hofschuster, E, Mempel, W, Eckstein, RCellular immunity in schizophrenic patients before and during neuroleptic treatment. Psychiatry Res 1991; 37: 147–160Google ScholarPubMed
Narayan, O, Herzog, S, Frese, K, Scheefers, H, Rott, RPathogenesis of Borna disease in rats: immune-mediated viral opthalmoencephalopathy causing blindness and behavioral abnormalities. J Infect Dis 1983; 148: 305–315CrossRefGoogle ScholarPubMed
Olsson, T, Kostulas, V, Link, HImproved detection of oligoclonal IgG in cerebrospinal fluid by isoelectric focusing in agarose, double-antibody paroxidase labeling and avidinbiotin amplification. Clin Chem 1984; 7: 1246–1249CrossRefGoogle Scholar
Pitts, AF, Brendan, TC, Gehris, TL, Kathol, RG, Samuelson, SDElevated CSF protein in male patients with depression. Biol Psychiatry 1990; 28: 629–637Google ScholarPubMed
Prange, HW, Moskophidis, M, Schipper, H, Müller, FRelationship between neurological features and intrathecal synthesis of IgG antibodies to Treponema pallidum in untreated and treated human neurosyphilis. J Neurol 1983; 230: 241–252CrossRefGoogle ScholarPubMed
Prange, HW, Ritter, GSpecific antibody activity as an indicator of local immune response to CNS infection (demonstrated in cases with syphilis and herpes zoster). Nervenarzt 1986; 57: 14–18Google Scholar
Preskorn, SH, Hartmann, BK, Irwin, GH, Hughes, CWRole of the central adrenergic system in mediating amitriyptyline-induced alteration in mammalian blood-brain barrier in vivo. J Pharmacol Exp Ther 1982; 223: 388–394Google ScholarPubMed
Propping, PGenetic disorders presenting as “schizophrenia”. Karl Bonhoeffer's early view of the psychoses in the light of medical genetics. Hum Genet 1983; 65: 1–10CrossRefGoogle ScholarPubMed
Quitkin, F, Rifkin, A, Klein, DFNeurologic soft signs in schizophrenia and character disorders. Organicity in schizophrenia with premorbid asociality and emotionally unstable character disorders. Arch Gen Psychiatry 1976; 33: 845–853CrossRefGoogle ScholarPubMed
Reiber, H, Felgenhauer, KProtein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system. Clin Chim Acta 1987; 163: 319–328Google ScholarPubMed
Reiber, HUntersuchungen des Liquors zur Diagnose neuroleptischer ErkrankungenHolzgraefe, M, Reiber, H, Felgenhauer, KLabordiagnostik von Erkrankungen des Nervensystems Erlangen: Perimed, 1988; 35–50Google Scholar
Reiber, HAktuelle Methoden der Liquoranalytik. Labormedizin 1988; 12: 101–109Google Scholar
Reiber, HDescreased flow of cerebrospinal fluid (CSF) as origin of the pathological increase of protein concentration in CSFFelgenhauer, K, Holzgraefe, M, Prange, HWCNS barriers and modern CSF diagnostics. Centennial of Quincke 's lumbar puncture Weinheim, New York: VCH, 1993; 305–317Google Scholar
Richt, J, Vande Woude, S, Zine, M, Narayan, D, Clements, JAnalysis of Borna disease virus-specific RNA's in infected cells and tissues. J Gen Virol 1991; 72: 2251–2255CrossRefGoogle Scholar
Rieht, JA, Herzog, S, Pyper, Jet al.Borna disease virus: nature of the etiologic agent and significance of infection in man. Arch Virol 1993; 7: 101–109Google Scholar
Roos, PR, Davis, K, Meltzer, HYImmunoglobulin studies in patients with psychiatric diseases. Arch Gen Psychiatry 1985; 42: 124–128Google ScholarPubMed
Rott, R, Herzog, S, Fleischer, Bet al.Detection of serum-antibodies to Borna disease virus in patients with psychiatric disorders. Science 1985; 228: 755–756Google ScholarPubMed
Rott, R, Herzog, S, Bechter, K, Frese, KBorna disease, a possible hazard for man?. Arch Virol 1991; 118: 143–149CrossRefGoogle ScholarPubMed
Rott, R, Herzog, S, Cash, ET-cell memory specific for self and non-self antigens in rats persistently infected with Borna disease virus. Clin Exp Immunol 1993; 93: 370–376CrossRefGoogle ScholarPubMed
Royston, MC, Lewis, SWBrain pathology in schizophrenia: developmental or degenerative?. Curr Op Psychiatry 1993; 6: 70–73CrossRefGoogle Scholar
Samuelson, SD, Winokur, G, Pitts, AFElevated cerebrospinal fluid protein in men with unipolar or bipolar depression. Biol Psychiatry 1994; 35: 539–544CrossRefGoogle ScholarPubMed
Schott, K, Batra, A, Klein, R, Bartels, M, Koch, W, Berg, PAAntibodies against serotonin and gangliosides in schizophrenia and major depressive disorder. Eur Psychiatry 1992; 7: 209–212CrossRefGoogle Scholar
Seifried, O, Spatz, HDie Ausbreitung der encephalitischen Reaktion bei der Borna'schen Krankheit der Pferde und deren Beziehungen zu der Encephalitis epidemica, der Heine-Medinschen Krankheit und der Lyssa des Menschen. Eine vergleichend-pathologische Studie. Zentralbl Neurol 1930; 124: 317–382Google Scholar
Simpson, GM, Cooper, TBThe effect of phenothiazines on cerebrospinal fluid. Int J Neuropsychiatry 1966; 66: 223–226Google Scholar
Smith, JSpinal fluid changes during chlorpromazine therapy. Am J Psychiatry 1958; 115: 167–169CrossRefGoogle ScholarPubMed
Sprankel, H, Richarz, K, Ludwig, H, Rott, RBehavior alterations in tree shrews (tupaia glis, Diard 1820) induced by Borna disease virus. Med Microbiol Immunol 1978; 165: 1–18CrossRefGoogle ScholarPubMed
Thierer, J, Riehle, H, Grebenstein, Oet al.The 24K protein of Borna disease virus. J Gen Virol 1992; 73: 413–416Google ScholarPubMed
Torrey, EF, Peterson, MThe viral hypothesis of schizophrenia. Schizophr Bull 1976; 1: 136–146CrossRefGoogle Scholar
Ullmann, H, Kühn, JVaricella-Zoster virus infection of the CNS with symptoms resembling cardiophobia or schizophrenia. Nervenarzt 1988; 59: 113–117Google ScholarPubMed
Vande Woude, S, Rieht, JA, Zink, MC, Rott, R, Narayan, O, Clements, JEA Borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases. Science 1990; 250: 1278–1281CrossRefGoogle Scholar
Weinberger, DRThe pathogenesis of schizophrenia: a neurodevelopmental theoryNasrallah, HA, Weinberger, DRThe neurology of schizophrenia Amsterdam, New York: Elsevier, 1986; 367–406Google Scholar
World Health Organisation Tenth revision of the international classification of diseases. Chapter V (F): mental and behavioral disorders (including disorders of psychological development). Clinical description and diagnostic guidelines 1991 Bern, Göttingen: Huber, ed., 1991; 1Google Scholar
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