Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-28T16:07:36.194Z Has data issue: false hasContentIssue false
  • English
  • Français

In patients with schizophrenia, symptoms improvement can be uncorrelated with quality of life improvement

Published online by Cambridge University Press:  09 December 2011

K. Wilson-d’Almeida ,
A. Karrow ,
M.-C. Bralet ,
N. Bazin ,
M.-C. Hardy-Baylé  and
B. Falissard
K. Wilson-d’Almeida
Affiliation:
Inserm U669, Maison de Solenn, 97, boulevard du Port-Royal, 75679Paris cedex 14, France UMR-S0669, université Paris-Sud, université Paris Descartes, Paris, France
A. Karrow
Affiliation:
Universitätsklinik Hamburg-Eppendorf, Zentrum für Psychosoziale Medizin, Psychiatrie und Psychotherapie, Martinistr, 52, 20246Hamburg, Germany
M.-C. Bralet
Affiliation:
Inserm U669, Maison de Solenn, 97, boulevard du Port-Royal, 75679Paris cedex 14, France UMR-S0669, université Paris-Sud, université Paris Descartes, Paris, France CHS, Clermont-de-l’Oise, France
N. Bazin
Affiliation:
EA 4047, université Versailles Saint-Quentin, Versailles, France Service de psychiatrie, hôpital Richaud, 1, rue Richaud, 78000, Versailles, France
M.-C. Hardy-Baylé
Affiliation:
EA 4047, université Versailles Saint-Quentin, Versailles, France Service de psychiatrie, hôpital Richaud, 1, rue Richaud, 78000, Versailles, France
B. Falissard*
Affiliation:
Inserm U669, Maison de Solenn, 97, boulevard du Port-Royal, 75679Paris cedex 14, France UMR-S0669, université Paris-Sud, université Paris Descartes, Paris, France Département de santé publique, hôpital Paul-Brousse, AP'HP, Villejuif, France
*
⁎Corresponding author. Tel.: +33 6 81 82 70 76; fax: +33 1 58 41 28 43. E-mail address:[email protected] (B. Falissard).
Get access

Abstract

Objectives

Quality of life has been found to be associated with symptoms in patients with schizophrenia. Nevertheless, the mechanism that underlies this association is still unclear. The objective of this paper is to prospectively evaluate the quality of life of patients with schizophrenia in relation to the concurrent evolution of their symptoms, their expectations and their perceived position in life.

Methods

Participants included 306 outpatients with schizophrenia who were interviewed at baseline, 6 and 12 months, about their quality of life (Outcome revealed by Preference in Schizophrenia, OPS) and symptoms (Positive and Negative Syndrome Scale, PANSS).

Results

Quality of life relative to subject expectations remained stable over time. A decrease in symptoms was correlated to an increase in both expectations and perceived position in life but did not correlate to quality of life.

Conclusion

The level of expectations seems to play a major role in the subjective assessment of quality of life in patients with schizophrenia. Symptom improvement is not necessarily associated with quality of life improvement relative to subject expectations. Caregivers should be aware of this result so as to deal with possible disappointments in patients receiving a new efficient treatment.

Keywords

Quality of lifePatients’ expectationsSymptomsPosition in life
Type
Original article
Information
European Psychiatry , Volume 28 , Issue 3 , March 2013 , pp. 185 - 189
Copyright
Copyright © European Psychiatric Association 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aki, H.Tomotake, M.Kaneda, Y.Iga, J.Kinouchi, S.Shibuya-Tayoshi, S., et al.Subjective and objective quality of life, levels of life skills, and their clinical determinants in outpatients with schizophrenia. Psychiatry Res 2008;158(1):19–25.CrossRefGoogle ScholarPubMed
Blankenburg, W.Der Verlust der näturlichen Selbstverständlichkeit, Thieme, Stuttgart, 1971. Traduction française de Azorin et Tatossian: La perte de l’évidence naturelle, PUF; 1991.Google Scholar
Calman, K.C.Quality of life in cancer patients – an hypothesis. J Med Ethics 1984;10(3):124–127.CrossRefGoogle ScholarPubMed
Carr, A.J.Gibson, B.Robinson, P.G.Measuring quality of life: is quality of life determined by expectations or experience? BMJ 2001;322(7296):1240–1243.CrossRefGoogle ScholarPubMed
Deaton, A.Income, health, and well-being around the world: evidence from the Gallup World Poll. J Econ Perspect 2008;22(2):53–72.CrossRefGoogle ScholarPubMed
Defense mechanism. Encyclopædia Britannica 2011. Retrieved from http://www.britannica.com/EBchecked/topic/155704/defense-mechanism.Google Scholar
Falissard, B.Bazin, N.Hardy-Bayle, M.C.Outcome revealed by preference in schizophrenia (OPS): development of a new class of outcome measurements. Int J Methods Psychiatr Res 2006;15(3):139–145.CrossRefGoogle ScholarPubMed
Karow, A.Naber, D.Subjective well-being and quality of life under atypical antipsychotic treatment. Psychopharmacology 2002;162(1):3–10.CrossRefGoogle ScholarPubMed
Karow, A.Pajonk, F.Insight and quality of life in schizophrenia: recent findings and treatment implications. Curr Opin Psychiatry 2006;19(6):637–641.CrossRefGoogle ScholarPubMed
Kay, S.R.Fiszbein, A.Opler, L.A.The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13(2):261–276.CrossRefGoogle Scholar
Kovess-Masféty, V.Xavier, M.Kustner, B.M.Suchocka, A.Sevilla-Dedieu, C.Dubuis, J.Schizophrenia and quality of life: a one-year follow-up in four EU countries. BMC Psychiatry 2006;6:39.CrossRefGoogle ScholarPubMed
Lysaker, P.H.Roe, D.Yanos, P.T.Toward understanding the insight paradox: internalized stigma moderates the association between insight and social functioning, hope, and self-esteem among people with schizophrenia spectrum disorders. Schizophr Bull 2007;33(1):192–199.CrossRefGoogle ScholarPubMed
Mezzich, J.E.Psychiatry for the Person: articulating medicine's science and humanism. World Psychiatry 2007;6(2):65–67.Google ScholarPubMed
Mill, J.S.Utilitarianism. London: Parker, Son, and Bourn; 1863, http://www.archive.org/details/a592840000milluoft.Google Scholar
Mintz, A.R.Dobson, K.S.Romney, D.M.Insight in schizophrenia: a meta-analysis. Schizophr Res 2003;61(1):75–88.CrossRefGoogle ScholarPubMed
Narvaez, J.M.Twamley, E.W.McKibbin, C.L.Heaton, R.K.Patterson, T.L.Subjective and objective quality of life in schizophrenia. Schizophr Res 2008;98(1–3):201–208.CrossRefGoogle Scholar
Roe, D.Mashiach-Eizenberg, M.Lysaker, P.H.The relation between objective and subjective domains of recovery among persons with schizophrenia-related disorders. Schizophr Res 2011;131(1–3):133–138.CrossRefGoogle ScholarPubMed
Silverstein, S.M.Bellack, A.M.A scientific agenda for the concept of recovery as it applies to schizophrenia. Clin Psychol Rev 2008;28:1108–1124.CrossRefGoogle Scholar
Siris, S.G.Suicide and schizophrenia. J Psychopharmacol 2001;15(2):127–135.CrossRefGoogle Scholar
Smith, D.W.Phenomenology, The Stanford Encyclopedia of Philosophy, Zalta, Edward N. (ed.); 2011.Google Scholar
Statistical Analysis Software. Statistical Analysis Software. SAS Institute Inc: Cary, NC; 2004.Google Scholar
The Lancet 1991; editorial. 338:350–351.CrossRefGoogle Scholar
van der Gaag, M.Hoffman, T.Remijsen, M.Hijman, R.de Haan, L.van Meijel, B., et al.The five-factor model of the Positive and Negative Syndrome Scale II: a ten-fold cross-validation of a revised model. Schizophr Res 2006;85:280–287.CrossRefGoogle ScholarPubMed
Wehmeiera, P.M.Klugeb, M.Schneidera, E.Schachta, A.Wagnera, T.Schreiber, W.Quality of life and subjective well-being during treatment with antipsychotics in out-patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2007;31(3):703–712.CrossRefGoogle Scholar
World Health Organisation. World report on disability. Geneva Switzerland: WHO press; 2011.Google Scholar
Zahavi, D.Exploring the self: philosophical and psychopathological perspectives on self-experience. John Benjamins Publishing Company; 2000.CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.