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The impact of frailty on depressive disorder in later life: Findings from the Netherlands Study of depression in older persons

Published online by Cambridge University Press:  23 March 2020

R.M. Collard ,
M.H.L. Arts ,
A.H. Schene ,
P. Naarding ,
R.C. Oude Voshaar  and
H.C. Comijs
R.M. Collard*
Affiliation:
Department of Psychiatry, Radboud university medical center, Nijmegen, The Netherlands
M.H.L. Arts
Affiliation:
Mental Health Center Friesland, Department of Old Age Psychiatry, Leeuwarden, The Netherlands University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Groningen, The Netherlands
A.H. Schene
Affiliation:
Department of Psychiatry, Radboud university medical center, Nijmegen, The Netherlands Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands
P. Naarding
Affiliation:
GGNet, Department of Old-age Psychiatry, Apeldoorn/Zutphen, The Netherlands
R.C. Oude Voshaar
Affiliation:
University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Groningen, The Netherlands
H.C. Comijs
Affiliation:
GGZinGeest, Amsterdam, The Netherlands Department Psychiatry/EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
*
*Corresponding author. Department of Psychiatry (hp 975B), Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Tel.: +0031 24 3614177. E-mail address:[email protected] (R.M. Collard).
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Abstract

Background:

Physical frailty and depressive symptoms are reciprocally related in community-based studies, but its prognostic impact on depressive disorder remains unknown.

Methods:

A cohort of 378 older persons (≥ 60 years) suffering from a depressive disorder (DSM-IV criteria) was reassessed at two-year follow-up. Depressive symptom severity was assessed every six months with the Inventory of Depressive Symptomatology, including a mood, motivational, and somatic subscale. Frailty was assessed according to the physical frailty phenotype at the baseline examination.

Results:

For each additional frailty component, the odds of non-remission was 1.24 [95% CI = 1.01–1.52] (P = 040). Linear mixed models showed that only improvement of the motivational (P < 001) subscale and the somatic subscale (P = 003) of the IDS over time were dependent on the frailty severity.

Conclusions:

Physical frailty negatively impacts the course of late-life depression. Since only improvement of mood symptoms was independent of frailty severity, one may hypothesize that frailty and residual depression are easily mixed-up in psychiatric treatment.

Keywords

FrailtyDepressionOlder personsNetherlands study of depression in older persons
Type
Original article
Information
European Psychiatry , Volume 43 , June 2017 , pp. 66 - 72
Copyright
Copyright © European Psychiatric Association 2017

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