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Has there been a decrease in the prevalence of mood disorders in HIV-seropositive individuals since the introduction of combination therapy?

Published online by Cambridge University Press:  16 April 2020

A. Alciati ,
F. Starace ,
B. Scaramelli ,
M. Campaniello ,
B. Adriani ,
C. Mellado  and
A. Cargnel
A. Alciati
Affiliation:
Dept. of Psychiatry, Ospedale L. Sacco, Milan, Italy
F. Starace*
Affiliation:
Consultation Psychiatry Service, Ospedale D. Cotugno, and Institute of Psychiatry, University of Naples, SUN, Italy
B. Scaramelli
Affiliation:
Dept. of Psychiatry, Ospedale L. Sacco, Milan, Italy
M. Campaniello
Affiliation:
2nd Dept. of Infectious Diseases, Ospedale L. Sacco, Milan, Italy
B. Adriani
Affiliation:
2nd Dept. of Infectious Diseases, Ospedale L. Sacco, Milan, Italy
C. Mellado
Affiliation:
Dept. of Psychiatry, Ospedale L. Sacco, Milan, Italy
A. Cargnel
Affiliation:
2nd Dept. of Infectious Diseases, Ospedale L. Sacco, Milan, Italy
*
*Correspondence and reprints: Consultation Psychiatry Service, Cotugno Hospital, Via G. Quagliariello, 54, 80131 - Napoli, Italy. E-mail address:[email protected] (F. Starace).
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Summary

Purpose.

The aim of this study was to assess the prevalence of current mood disorders in HIV-seropositive patients treated with combined antiretroviral drug therapy including or not protease inhibitors.

Subjects and methods.

A random sample of 90 subjects consecutively attending, between February 1 and July 31, 1998, the outpatient unit of the Second Department of Infectious Diseases of the ‘L. Sacco’ Hospital in Milan was assessed by means of the Structured Clinical Interview for DSMIII-R (SCID) and the Zung Self-Rating Depression Scale (ZSDS).

Results.

Twenty-three-point-three percent of the subjects were classified in CDC stage A, 32.3% in CDC stage B and 44.4% in CDC stage C. A DSMIII-R psychiatric diagnosis of current mood disorder was found in 4.4% of the recruited sample (dysthymia: 2.2%; adjustment disorder with depressed mood: 2.2%).

Conclusions.

Direct and indirect effect of new combination therapies, epidemiological changes in social groups affected by HIV and possible modifications in social perception of people with HIV infection may explain, at least in part, the decreased prevalence of current mood disorders observed in our study as compared to prevalence rates reported in the pre-HAART era.

Keywords

depressionHAARTHIVmood disordersprevalence study
Type
Original Articles
Information
European Psychiatry , Volume 16 , Issue 8 , December 2001 , pp. 491 - 496
Copyright
Copyright © 2001 Éditions scientifiques et médicales Elsevier SAS

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References

Brechtl, JRBreitbart, WGalietta, MKrivo, SRosenfeld, B.The use of highly active antiretroviral therapy (HAART) in patients with advanced HIV infection: Impact on medical, palliative care and quality of life outcomes. J Pain Sympt Man 2001; 21: 41–51.CrossRefGoogle ScholarPubMed
Burack, JHBarrett, CStall, RDChesney, MAEkstrand, MLCoates, TJ.Depressive symptoms and CD4 lymphocyte decline among HIV-infected men. JAMA 1993; 15: 139–47.Google Scholar
Cavanaugh, S.Diagnosing depression in the hospitalised patient with chronic medical illness. J Clin Psychiatry 1984; 45: 13–6.Google Scholar
Chuang, HJason, JWPajurkova, EM. et al. Psychiatric morbidity in patients with HIV infection. Can J Psychiatry 1992; 37: 109–15.CrossRefGoogle ScholarPubMed
Dugan, WMcDonald, MVPassik, SDRosenfeld, BDTheobald, DEdgerton, S.Use of the Zung Self-Rating Depression Scale in cancer patients: feasibility as a screening tool. Psychooncol 1998; 7: 483–93.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Filippi, CGSze, GFarber, SJShahmanesh, MSelwyn, PA.Regression of HIV encephalopathy and basal ganglia signal intensity abnormality at MR imaging in patients with AIDS after the initiation of protease inhibitor therapy. Radiology 1998; 206: 491–8.CrossRefGoogle ScholarPubMed
Flexner, C.HIV-protease inhibitors. NEJM 1998; 338: 1281–92.CrossRefGoogle ScholarPubMed
Foudraine, NAHetelmans, RMWLange, JA.Cerebrospinal fluid HIV-1 RNA and drug concentration after treatment with lamivudine plus zidovudine or stavudine. Lancet 1998; 351: 1547–51.CrossRefGoogle ScholarPubMed
Gala, CPergami, PCatalan, JDurbano, FMusicco, MRiccio, M. et al. The psychosocial impact of HIV infection in gay men, drug users and heterosexuals. Br J Psychiatry 1993; 163: 651–9.CrossRefGoogle ScholarPubMed
Gisslen, MNorkrans, GSvennerholm, BHagbrg, L.HIV-1 RNA detectable with ultrasensitive quantitative polymerase chain reaction in plasma but not in cerebrospinal fluid during combination treatment with zidovudine, lamivudine and indinavir. AIDS 1998; 12: 114–6.Google Scholar
Hintz, SKuck, JPeterkin, JJVolk, DMZisook, S.Depression in the context of human immunodeficiency virus infection: implication for treatment. J Clin Psychiatry 1990; 51: 497–501.Google Scholar
Ickovics, JRHamburger, MEVlahov, DSchoenbaum, EESchuman, PBoland, RJ. et al. Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women. JAMA 2001; 285: 1466–74.CrossRefGoogle ScholarPubMed
Judd, FKCockram, AMKomiti, AMijich, AMHoy, JBell, R.Depressive symptoms reduced in individuals with HIV/AIDS treated with antiretroviral therapy: a longitudinal study. Aust N Z J Psychiatry 2000; 34: 1015–21.CrossRefGoogle ScholarPubMed
Leserman, JPetito, JMPerkins, DOGolden, RNEvans, DL.Severe stress, depressive symptoms, and changes in lymphocyte subsets in human immunodeficiency virus-infected men. Arch Gen Psychiatry 1997; 54: 279–85.CrossRefGoogle ScholarPubMed
Lipsitz, JDWilliams, JBWRabKin, JGRemien, RH.Psychopathology in male and female intravenous drug users with and without HIV infection. Am J Psychiat 1994; 151: 1662–8.Google ScholarPubMed
Low-Beer, SChan, KYip, BWood, EMontaner, JSG.O'Shaughnessy MV, Hogg RS. Depressive symptoms decline among persons on HIV protease inhibitors. J Acq Imm Defic Syndr 2000; 23: 295–301.CrossRefGoogle ScholarPubMed
Lyketsos, CGHoover, DRGuccione, MDew, MAWesch, JEBing, EGTreisman, GJ.Changes in depressive symptoms as AIDS develops. Am J Psychiat 1996; 153: 1430–7.Google ScholarPubMed
Maj, MJanssen, RStarace, FZaudig, MSatz, PSughondhabirom, BLuabeya, MARiedel, RNdetei, DCalil, HM.WHO Neuropsychiatric AIDS Study, cross-sectional phase. I. Study design and psychiatric findings. Arch Gen Psychiatry 1994; 51: 39–49.CrossRefGoogle ScholarPubMed
Maj, M.Depressive syndromes and symptoms in subjects with human immunodeficiency virus (HIV) infection. Br J Psychiatry 1996; 168: 117–22.CrossRefGoogle Scholar
Perry, SJacobsberg, LBFishman, BFrances, ABobo, JJacobsberg, BK.Psychiatric diagnosis before serological testing for the human immunodeficiency virus. Am J Psychiatry 1990; 147: 89–93.Google ScholarPubMed
Power, CKong, PCrawford, T.Cerebral white matter changes in acquired immunodeficiency syndrome dementia: alterations in the blood-brain barrier. Ann Neurol 1993; 34: 339–50.CrossRefGoogle ScholarPubMed
Price, RBrew, BSidtis, J.The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 1988; 239: 586–92.CrossRefGoogle ScholarPubMed
Rabkin, JGFerrando, SJLin, SHSewell, MMcElhiney, M.Psychological effects of HAART: a 2-year study. Psychosom M 2000; 62: 413–22.CrossRefGoogle ScholarPubMed
Rosemberger, PHBoernstein, RANasrallah, HAPara, MFWhitacre, CCFass, RJ. et al. Psychopathology in immunodeficiency virus infection: lifetime and current assessment. Compr Psychiatry 1993; 34: 150–8.CrossRefGoogle Scholar
Singh, NSquier, CSivek, CWagener, MHong Nguyen, MYu, VL.Determinants of compliance with antiretroviral therapy in patients with human immunodeficiency virus: prospective assessment with implications for enhancing compliance. AIDS Care 1996; 8: 261–9.CrossRefGoogle ScholarPubMed
Spitzer, RWilliams, JBWGibbon, MFirst, MB.The structured clinical interview for DSMIII-R (SCID). I. History, rationale and description. Arch Gen Psychiatry 1992; 49: 624–9.CrossRefGoogle Scholar
Williams, JBWRabkin, JGRemien, RHGorman, JMEhrhardt, AA.Multidisciplinary baseline assessment of homosexual men with and without human immunodeficiency virus infection. II. Standardised clinical assessment of current and lifetime psychopathology. Arch Gen Psychiatry 1991; 48: 124–30.CrossRefGoogle Scholar
Zung, WK.A self-rating depression scale. Arch Gen Psychiatry 1965; 12: 93–160.CrossRefGoogle ScholarPubMed
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