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The genetics of affective disorder and suicide

Published online by Cambridge University Press:  16 April 2020

P. McGuffin ,
N. Perroud ,
R. Uher ,
A. Butlera ,
K.J. Aitchison ,
I. Craig ,
C. Lewis  and
A. Farmer
P. McGuffin*
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
N. Perroud
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
R. Uher
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
A. Butlera
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
K.J. Aitchison
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
I. Craig
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
C. Lewis
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
A. Farmer
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, LondonSE5 8AF, United Kingdom
*
*Corresponding author. E-mail address: [email protected] (P. McGuffin).
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Abstract

Suicidal behaviour shows evidence of familial clustering and the twin data on completed suicide suggest moderate heritability. The extent to which the genetics of suicidal behaviour overlaps with the genetics of affective disorders is unclear but there is overwhelming evidence that both bipolar and unipolar disorder are substantially influenced by genes. So far, candidate gene studies of suicidality have provoked much interest, but recently, attention has also turned to candidate gene approaches to suicidal ideation emerging during antidepressant treatment. The advent of genome-wide association studies (GWAS) has had a major impact on studies of affective disorder with some provocative new findings. The GWAS approach is also beginning to be applied in the search for genes that underlie suicidal ideation and behaviour.

Keywords

GeneticsSuicideGenome-wide association studies (GWAS)Affective disorder
Type
Original article
Information
European Psychiatry , Volume 25 , Issue 5: The role of genetics in promoting suicide prevention and the mental health of the population - Nobel Conference: The role of genetics in promoting suicide prevention and the mental health of the population , June 2010 , pp. 275 - 277
Copyright
Copyright © Elsevier Masson SAS 2010

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Further reading

McGuffin, P, Marusic, A, Farmer, AWhat can psychiatric genetics offer suicidology? Crisis 2001;22:61–5.10.1027//0227-5910.22.2.61CrossRefGoogle ScholarPubMed
The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls. Nature 2007;447:661–83.CrossRefGoogle Scholar
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