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Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with personality traits in healthy individuals

Published online by Cambridge University Press:  16 April 2020

Axel Krug ,
Valentin Markov ,
Dirk Leube ,
Klaus Zerres ,
Thomas Eggermann ,
Markus M. Nöthen ,
Markus H. Skowronek ,
Marcella Rietschel  and
Tilo Kircher
Axel Krug
Affiliation:
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, D-52074Aachen, Germany
Valentin Markov
Affiliation:
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, D-52074Aachen, Germany
Dirk Leube
Affiliation:
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, D-52074Aachen, Germany
Klaus Zerres
Affiliation:
Institute of Human Genetics, RWTH Aachen University, Pauwelsstrasse 30, D-52074Aachen, Germany
Thomas Eggermann
Affiliation:
Institute of Human Genetics, RWTH Aachen University, Pauwelsstrasse 30, D-52074Aachen, Germany
Markus M. Nöthen
Affiliation:
Department of Genomics, Life and Brain Center, University of Bonn, Sigmund-Freud-Strasse 25, D-53127Bonn, Germany
Markus H. Skowronek
Affiliation:
Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, J5, D-68159Mannheim, Germany
Marcella Rietschel
Affiliation:
Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, J5, D-68159Mannheim, Germany
Tilo Kircher*
Affiliation:
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, D-52074Aachen, Germany
*
*Corresponding author. Tel.: +49 241 8088637; fax: +49 241 8082422. E-mail addresses: [email protected] (A. Krug), [email protected] (V. Markov), [email protected] (K. Zerres), [email protected] (T. Eggermann), [email protected] (M.M. Nöthen), markus. [email protected] (M.H. Skowronek), [email protected] (M. Rietschel), [email protected] (T. Kircher).
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Abstract

Background

Differences in personality traits have long been acknowledged as potential risk factors in developing psychiatric disorders. Lately, several susceptibility genes of different psychiatric disorders have been linked to personality traits. This has not been done for schizophrenia yet. Neuregulin1 has been repeatedly shown to be associated with schizophrenia and is involved in numerous neurodevelopmental functions such as neuronal migration and myelination. The impact of this gene might also modulate personality traits in healthy subjects.

Methods

The NRG1 status of 523 healthy subjects was determined with a single nucleotide polymorphism (SNP8NRG221533) which has been described as a tagging marker being part of the core at-risk haplotype for schizophrenia. Genotype was correlated with personality traits using the NEO-FFI questionnaire.

Results

Subjects with the NRG1 risk allele scored higher on neuroticism (p <.05) and lower on conscientiousness (p <.05). Further, interactions of genotype by gender for extraversion (p <.05), openness (p <.05) and conscientiousness (p <.05) were found with men carrying the risk allele scoring the lowest.

Conclusions

The data indicate that the NRG1 gene which has found to be associated with schizophrenia may also influence personality differences in healthy subjects.

Keywords

Personality traitsNEO-FFINeuregulinNRG1Genotype
Type
Original article
Information
European Psychiatry , Volume 23 , Issue 5 , August 2008 , pp. 344 - 349
Copyright
Copyright © Elsevier Masson SAS 2008

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