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Gender-based differences in oxidative stress parameters do not underlie the differences in mood disorders susceptibility between sexes

Published online by Cambridge University Press:  15 April 2020

C. Wiener ,
G.T. Rassier ,
M.P. Kaster ,
K. Jansen ,
R.T. Pinheiro ,
F. Klamt ,
P.V. Magalhães ,
F. Kapczinski ,
G. Ghisleni  and
R.A. da Silva
C. Wiener
Affiliation:
Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil
G.T. Rassier
Affiliation:
Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil
M.P. Kaster
Affiliation:
Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil
K. Jansen
Affiliation:
Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil
R.T. Pinheiro
Affiliation:
Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil
F. Klamt
Affiliation:
Universidade Federal do Rio Grande do Sul (UFRGS), Biochemistry Department, Brazil
P.V. Magalhães
Affiliation:
Universidade Federal do Rio Grande do Sul (UFRGS), National Institute for Translational Medicine, Hospital de Clínicas de Porto Alegre, Brazil
F. Kapczinski
Affiliation:
Universidade Federal do Rio Grande do Sul (UFRGS), National Institute for Translational Medicine, Hospital de Clínicas de Porto Alegre, Brazil
G. Ghisleni*
Affiliation:
Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil
R.A. da Silva
Affiliation:
Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil
*
*Corresponding author. Programa de Pós-Graduação em Saúde e Comportamento, Centro de Ciências da Vida e da Saúde, Universidade Católica de Pelotas, Rua Gonçalves Chaves 373, 96015560, Pelotas, Rio Grande do Sul, Brasil. Tel.: +55 53 2128 8031; fax: +55 53 2128 8229. E-mail address:[email protected] (G. Ghisleni).
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Abstract

The present study aimed to determine whether any gender-related difference exists concerning oxidative stress parameters in a population of 231 subjects, and if these changes might be related to gender-associated differences in major depressive disorder (MDD) or bipolar disorder (BD) vulnerability. This is a case-control nested in a population-based study. The initial psychopathology screen was performed with the Mini-International Neuropsychiatric Interview and the diagnostic was further confirmed with the Structured Clinical Interview for DSM-IV. Blood samples were obtained after the interview and the oxidative stress parameters such as uric acid, advanced oxidation protein product (PCC) and lipid hydroperoxides (TBARS) were determined. Our results indicated a higher prevalence of MDD and BD in women when compared to men. In addition, significant gender differences were found in the levels of PCC (0.27 ± 0.27 vs. 0.40 ± 0.31 nmol CO/mg protein, men vs. women, respectively; P = 0.02) and uric acid (4.88 ± 1.39 mg/dL vs. 3.53 ± 1.02 mg/dL, men vs. women, respectively; P = 0.0001), but not in TBARS (0.013 ± 0.01 nmol/mg of protein vs. 0.017 ± 0.02 nmol/mg of protein, men vs. women respectively; P = 0.243). After sample stratification by gender, no association was found between oxidative stress parameters and clinical diagnosis of MDD and BD for women (P = 0.516 for PCC; P = 0.620 for TBARS P = 0.727 for uric acid) and men (P = 0.367 for PCC; P = 0.372 for TBARS P = 0.664 for uric acid). In this study, women seem more susceptible to oxidative stress than male. However, these gender-based differences do not seem to provide a biochemical basis for the epidemiologic differences in mood disorders susceptibility between sexes.

Keywords

Oxidative stressGenderMajor depressive disorderBipolar disorder
Type
Original article
Information
European Psychiatry , Volume 29 , Issue 1 , January 2014 , pp. 58 - 63
Copyright
Copyright © 2013 Elsevier Masson SAS

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