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Further Evidence of Depdc7 Dna Hypomethylation in Depression: a Study in Adult Twins

Published online by Cambridge University Press:  04 May 2015

A. Córdova-Palomera ,
M. Fatjó-Vilas ,
H. Palma-Gudiel ,
H. Blasco-Fontecilla ,
O. Kebir  and
L. Fañanás
A. Córdova-Palomera
Affiliation:
Unitat d’Antropologia, Departament de Biologia Animal, Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain Centro de Investigaciones Biomédicas en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
M. Fatjó-Vilas
Affiliation:
Unitat d’Antropologia, Departament de Biologia Animal, Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain Centro de Investigaciones Biomédicas en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
H. Palma-Gudiel
Affiliation:
Unitat d’Antropologia, Departament de Biologia Animal, Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain
H. Blasco-Fontecilla
Affiliation:
Centro de Investigaciones Biomédicas en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain Department of Psychiatry, IDIPHIM-Puerta de Hierro University Hospital, Madrid, Spain
O. Kebir
Affiliation:
Inserm, centre de psychiatrie et neurosciences, UMR 894, laboratoire de physiopathologie des maladies psychiatriques, université Paris Descartes, PRES Paris Sorbonne Cité, Paris, France Service hospitalo-universitaire, faculté de médecine Paris Descartes, hôpital Sainte-Anne, Paris, France GDR3557, institut de psychiatrie, Paris, France
L. Fañanás*
Affiliation:
Unitat d’Antropologia, Departament de Biologia Animal, Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain Centro de Investigaciones Biomédicas en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
*
*Corresponding author. Tel.: +34 9340 21461; fax: +34 9340 35740. E-mail address: [email protected] (L. Fanãanás).
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Abstract

Late and early stressful factors have widely been recognized to play a role in the aetiology of depression. Recent research indicates that such adverse environmental stimuli may alter gene expression in humans via epigenetic modifications. While epigenetic changes such as DNA methylation are likely involved in these processes, it is still unknown what specific genomic loci may be hyper- or hypo-methylated in depression. The association between depressive symptoms during the last 30 days (Brief Symptom Inventory [BSI]) and peripheral-blood DNA methylation levels at genomic loci previously reported as epigenetically altered in saliva and brain of depressive patients was evaluated in a community sample of 34 adult Caucasian MZ twins (17 pairs). Intrapair DNA methylation differences in an intron of DEPDC7 (chr11:33040743) were associated with intrapair differences in current depressive symptoms. Accordingly, a site-specific 10% DNA hypomethylation in a co-twin would correlate with a current depressive symptom score around 3.1 BSI points above the score of his/her less-depressed co-twin. These findings indicate that DEPDC7 hypomethylation in peripheral blood DNA may be associated with recent depressive symptomatology, in line with previous results.

Keywords

DNA methylationDepressionMZ twinsBrief Symptom InventoryDEPDC7
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 6 , September 2015 , pp. 715 - 718
Copyright
Copyright © Elsevier Masson SAS 2015

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