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Factors associated with depression in Parkinson’s disease: a cross-sectional study in a Polish population

Published online by Cambridge University Press:  16 April 2020

Hubert M. Wichowicz ,
Jarosław Sławek ,
Mirosława Derejko  and
Wiesław Jerzy Cubała
Hubert M. Wichowicz*
Affiliation:
1st Department of Psychiatry, Medical University, Gdańsk, Dębinki 7 St.80-952Gdańsk, Poland
Jarosław Sławek
Affiliation:
Department of Neurosurgery, Division of Functional Surgery and Movement Disorders, Medical University, Gdańsk, Poland
Mirosława Derejko
Affiliation:
Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland
Wiesław Jerzy Cubała
Affiliation:
1st Department of Psychiatry, Medical University, Gdańsk, Dębinki 7 St.80-952Gdańsk, Poland
*
*Corresponding author. Tel.: +48 58 349 2650; fax: +48 58 349 2748. E-mail address: [email protected] (H.M. Wichowicz).
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Abstract

Objective

The aim of this study was to assess the prevalence and factors influencing depression in PD patients in a cross-sectional outpatient clinic - based Polish patients sample.

Materials and methods

One hundred consecutive PD patients were included in this study; 35 of them fulfilled DSM-IV criteria for Major Depression and its severity was assessed with Montgomery–Asberg Depression Rating Scale (MADRS). A structured interview and a neurological examination, including Hoehn and Yahr scale (H–Y), Schwab–England disability scale, II, III, IV parts of Unified Parkinson's Disease Rating Scale (UPDRS), and Mini-Mental State Examination (MMSE) were performed. The parameters obtained were analysed between the depressed and non-depressed PD patients.

Results

The prevalence of depression in PD in Polish population was established at the level of 35%. PD patients with depression scored significantly higher in all UPDRS scales (except for the subscale of clinical fluctuation) and in H–Y scale. PD with depression was also associated with longer PD duration, higher doses of L-dopa equivalents, patients' age, general impairment of daily living in Schwab and England disability scale, lower MMSE and higher clinical fluctuations. However, those six differences were insignificant.

Conclusions

Depression prevalence rate among PD patients in Polish population is slightly lower than in most of other published studies. This may result from strict selection criteria, use of specific outcome measures and restricted criteria for depression that were applied.

Keywords

Parkinson’s diseaseDepressionComorbidity
Type
Original article
Information
European Psychiatry , Volume 21 , Issue 8 , December 2006 , pp. 516 - 520
Copyright
Copyright © Elsevier Masson SAS 2006

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