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Elevated total plasma-adiponectin is stable over time in young women with bulimia nervosa

Published online by Cambridge University Press:  03 February 2017

M. Syk ,
M. Ramklint ,
R. Fredriksson ,
L. Ekselius  and
J.L. Cunningham
M. Syk
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Entrance 10, Floor 3B, 75185Uppsala, Sweden
M. Ramklint
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Entrance 10, Floor 3B, 75185Uppsala, Sweden
R. Fredriksson
Affiliation:
Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 75124Uppsala, Sweden
L. Ekselius
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Entrance 10, Floor 3B, 75185Uppsala, Sweden
J.L. Cunningham*
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Entrance 10, Floor 3B, 75185Uppsala, Sweden
*
⁎Corresponding author. E-mail address: [email protected] (J.L. Cunningham).
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Abstract

Background

Bulimia nervosa (BN) is characterized by dysregulated eating behaviour and present data suggest adipokines may regulate food intake. We investigated a possible association between BN and adipokine levels and hypothesized that plasma (P)-adiponectin would be elevated and P-leptin and P-leptin-adiponectin-ratio would be reduced in women with BN.

Methods

The study was designed as a cross-sectional study with a longitudinal arm for patients with BN. Plasma-adiponectin and leptin was measured in 148 female patients seeking psychiatric ambulatory care and 45 female controls. Fifteen patients were diagnosed with BN and the remaining with other affective and anxiety disorders. P-adiponectin and P-leptin levels were compared between patients with BN, patients without BN and controls. At follow-up 1–2 years later, adipokines were reassessed in patients with BN and the Eating Disorder Examination Questionnaire was used to assess symptom severity.

Results

P-adiponectin was elevated in patients with BN at baseline and at follow-up when compared to patients without BN and controls (P < 0.004 and < 0.008 respectively). The difference remained significant after controlling for body mass index. P-adiponectin was correlated to symptom severity at follow-up in patients with BN without morbid obesity (ρ = 0.72, P < 0.04). P-leptin-adiponectin-ratio was significantly lower in patients with BN compared to controls (P < 0.04) and P-leptin non-significantly lower.

Conclusions

Findings indicate a stable elevation of P-adiponectin in women with BN. P-adiponectin at follow-up correlates to eating disorder symptom severity in patients without morbid obesity, indicating that P-adiponectin should be further investigated as a possible potential prognostic biomarker for BN.

Keywords

Bulimia nervosaAdiponectinLeptinBiomarkerPrognosis
Type
Original article
Information
European Psychiatry , Volume 41 , Issue 1 , March 2017 , pp. 30 - 36
Copyright
Copyright © European Psychiatric Association 2017

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Footnotes

Abbreviations: BN, Bulimia nervosa; UPP, Uppsala psychiatric patient samples.

References

Association A.P.. Diagnostic and statistical manual of mental disorders: DSM-IV-TR, 4th ed., American Psychiatric Association, Washington, DC; 2000.Google Scholar
Hoek, H.W.van Hoeken, D.Review of the prevalence and incidence of eating disorders. Int J Eat Disord 2003;34:383–396.CrossRefGoogle ScholarPubMed
Kissileff, H.R.Wentzlaff, T.H.Guss, J.L.Walsh, B.T.Devlin, M.J.Thornton, J.C.A direct measure of satiety disturbance in patients with bulimia nervosa. Physiol Behav 1996;60:1077–1085.CrossRefGoogle ScholarPubMed
Klok, M.D.Jakobsdottir, S.Drent, M.L.The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev 2007;8:21–34.CrossRefGoogle ScholarPubMed
Kubota, N.Yano, W.Kubota, T.Yamauchi, T.Itoh, S.Kumagai, H.et al.Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab 2007;6:55–68.CrossRefGoogle ScholarPubMed
Kadowaki, T.Yamauchi, T.Kubota, N.Hara, K.Ueki, K.Tobe, K.Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006;116:1784–1792.CrossRefGoogle ScholarPubMed
Kadowaki, T.Yamauchi, T.Kubota, N.The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS. FEBS Lett 2008;582:74–80.CrossRefGoogle ScholarPubMed
Ebinuma, H.Miida, T.Yamauchi, T.Hada, Y.Hara, K.Kubota, N.et al.Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid. Clin Chem 2007;53:1541–1544.CrossRefGoogle ScholarPubMed
Zhang, D.Guo, M.Zhang, W.Lu, X.Y.Adiponectin stimulates proliferation of adult hippocampal neural stem/progenitor cells through activation of p38 mitogen-activated protein kinase (p38MAPK)/glycogen synthase kinase 3beta (GSK-3beta)/beta-catenin signaling cascade. J Biol Chem 2011;286:44913–44920.CrossRefGoogle ScholarPubMed
Psilopanagioti, A.Papadaki, H.Kranioti, E.F.Alexandrides, T.K.Varakis, J.N.Expression of adiponectin and adiponectin receptors in human pituitary gland and brain. Neuroendocrinology 2009;89:38–47.CrossRefGoogle ScholarPubMed
Minokoshi, Y.Alquier, T.Furukawa, N.Kim, Y.B.Lee, A.Xue, B.et al.AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004;428:569–574.CrossRefGoogle ScholarPubMed
Lim, C.T.Kola, B.Korbonits, M.AMPK as a mediator of hormonal signalling. J Mol Endocrinol 2010;44:87–97.CrossRefGoogle ScholarPubMed
Coope, A.Milanski, M.Araujo, E.P.Tambascia, M.Saad, M.J.Geloneze, B.et al.AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. FEBS Lett 2008;582:1471–1476.CrossRefGoogle ScholarPubMed
Qi, Y.Takahashi, N.Hileman, S.M.Patel, H.R.Berg, A.H.Pajvani, U.B.et al.Adiponectin acts in the brain to decrease body weight. Nat Med 2004;10:524–529.CrossRefGoogle ScholarPubMed
Margetic, S.Gazzola, C.Pegg, G.G.Hill, R.A.Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 2002;26:1407–1433.CrossRefGoogle ScholarPubMed
Andersson, U.Filipsson, K.Abbott, C.R.Woods, A.Smith, K.Bloom, S.R.et al.AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 2004;279:12005–12008.CrossRefGoogle Scholar
Brewerton, T.D.Lesem, M.D.Kennedy, A.Garvey, W.T.Reduced plasma leptin concentrations in bulimia nervosa. Psychoneuroendocrinology 2000;25:649–658.CrossRefGoogle ScholarPubMed
Monteleone, P.Di Lieto, A.Tortorella, A.Longobardi, N.Maj, M.Circulating leptin in patients with anorexia nervosa, bulimia nervosa or binge-eating disorder: relationship to body weight, eating patterns, psychopathology and endocrine changes. Psychiatry Res 2000;94:121–129.CrossRefGoogle ScholarPubMed
Jimerson, D.C.Mantzoros, C.Wolfe, B.E.Metzger, E.D.Decreased serum leptin in bulimia nervosa. J Clin Endocrinol Metab 2000;85:4511–4514.Google ScholarPubMed
Monteleone, P.Fabrazzo, M.Tortorella, A.Fuschino, A.Maj, M.Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum. Mol Psychiatry 2002;7:641–646.CrossRefGoogle ScholarPubMed
Monteleone, P.Bortolotti, F.Fabrazzo, M.La Rocca, A.Fuschino, A.Maj, M.Plamsa leptin response to acute fasting and refeeding in untreated women with bulimia nervosa. J Clin Endocrinol Metab 2000;85:2499–2503.CrossRefGoogle ScholarPubMed
Baskaran, C.Eddy, K.T.Miller, K.K.Meenaghan, E.Misra, M.Lawson, E.A.Leptin secretory dynamics and associated disordered eating psychopathology across the weight spectrum. Eur J Endocrinol 2016;174:503–512.CrossRefGoogle ScholarPubMed
Monteleone, P.Fabrazzo, M.Martiadis, V.Fuschino, A.Serritella, C.Milici, N.et al.Opposite changes in circulating adiponectin in women with bulimia nervosa or binge eating disorder. J Clin Endocrinol Metab 2003;88:5387–5391.CrossRefGoogle ScholarPubMed
Tagami, T.Satoh, N.Usui, T.Yamada, K.Shimatsu, A.Kuzuya, H.Adiponectin in anorexia nervosa and bulimia nervosa. J Clin Endocrinol Metab 2004;89:1833–1837.CrossRefGoogle ScholarPubMed
Housova, J.Anderlova, K.Krizova, J.Haluzikova, D.Kremen, J.Kumstyrova, T.et al.Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa. J Clin Endocrinol Metab 2005;90:1366–1370.CrossRefGoogle ScholarPubMed
Sheehan, D.V.Lecrubier, Y.Sheehan, K.H.Amorim, P.Janavs, J.Weiller, E.et al.The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998;59(Suppl. 20):22–33 [quiz 4-57].Google ScholarPubMed
First, M.S.R.Gibbon, M.Williams, J.Structured Clinical Interview for DSM-IV Axis I Disorders. Clinician Version (SCID-CV) Washington, D.C.: American Psychiatric Press; 1996.Google Scholar
Olmsted, M.P.Kaplan, A.S.Rockert, W.Defining remission and relapse in bulimia nervosa. Int J Eat Disord 2005;38:1–6.CrossRefGoogle ScholarPubMed
Mond, J.M.Hay, P.J.Rodgers, B.Owen, C.Eating Disorder Examination Questionnaire (EDE-Q): norms for young adult women. Behav Res Ther 2006;44:53–62.CrossRefGoogle ScholarPubMed
Mond, J.M.Hay, P.J.Rodgers, B.Owen, C.Beumont, P.J.Validity of the Eating Disorder Examination Questionnaire (EDE-Q) in screening for eating disorders in community samples. Behav Res Ther 2004;42:551–567.CrossRefGoogle ScholarPubMed
Fairburn, C.Cognitive behavior therapy and eating disorders. Guilford Press, New York; 2008.Google ScholarPubMed
Carvalho, A.F.Rocha, D.Q.McIntyre, R.S.Mesquita, L.M.Kohler, C.A.Hyphantis, T.N.et al.Adipokines as emerging depression biomarkers: a systematic review and meta-analysis. J Psychiatr Res 2014;59:28–37.CrossRefGoogle ScholarPubMed
Jin, H.Meyer, J.M.Mudaliar, S.Jeste, D.V.Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectin. Schizophr Res 2008;100:70–85.CrossRefGoogle ScholarPubMed
Caro, J.F.Kolaczynski, J.W.Nyce, M.R.Ohannesian, J.P.Opentanova, I.Goldman, W.H.et al.Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996;348:159–161.CrossRefGoogle ScholarPubMed
Rohde, K.Keller, M.Horstmann, A.Liu, X.Eichelmann, F.Stumvoll, M.et al.Role of genetic variants in ADIPOQ in human eating behavior. Genes Nutr 2015;10:449.CrossRefGoogle ScholarPubMed
Halleux, C.M.Takahashi, M.Delporte, M.L.Detry, R.Funahashi, T.Matsuzawa, Y.et al.Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue. Biochem Biophys Res Commun 2001;288:1102–1107.CrossRefGoogle ScholarPubMed
Tabak, A.G.Brunner, E.J.Miller, M.A.Karanam, S.McTernan, P.G.Cappuccio, F.P.et al.Low serum adiponectin predicts 10-year risk of type 2 diabetes and HbA1c independently of obesity, lipids, and inflammation: Whitehall II study. Horm Metab Res 2009;41:626–629.CrossRefGoogle ScholarPubMed
Swanson, S.A.Crow, S.J.Le Grange, D.Swendsen, J.Merikangas, K.R.Prevalence and correlates of eating disorders in adolescents. Results from the national comorbidity survey replication adolescent supplement. Arch Gen Psychiatry 2011;68:714–723.CrossRefGoogle ScholarPubMed
Cizza, G.Nguyen, V.T.Eskandari, F.Duan, Z.Wright, E.C.Reynolds, J.C.et al.Low 24-hour adiponectin and high nocturnal leptin concentrations in a case-control study of community-dwelling premenopausal women with major depressive disorder: the Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression (POWER) study. J Clin Psychiatry 2010;71:1079–1087.CrossRefGoogle Scholar
Gavrila, A.Peng, C.K.Chan, J.L.Mietus, J.E.Goldberger, A.L.Mantzoros, C.S.Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. J Clin Endocrinol Metab 2003;88:2838–2843CrossRefGoogle ScholarPubMed
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