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Effects of tianeptine on sleep-wakefulness cycles in the rhesus monkey

Published online by Cambridge University Press:  16 April 2020

E Balzamo ,
D Lagarde ,
C Milhaud ,
E Mocaer  and
JC Poignant
E Balzamo
Affiliation:
Laboratoire de Biologie des Hautes-Pressions, URA 1630-CNRS, Faculté de Médecine Nord, Boulevard Pierre Dramard, 13326Marseille Cedex 15
D Lagarde
Affiliation:
CERMA, Division de Neurophysiologie Appliquée, 91228Bretigny-sur-Orge
C Milhaud
Affiliation:
CERMA, Division de Neurophysiologie Appliquée, 91228Bretigny-sur-Orge
E Mocaer
Affiliation:
IRIS, 6, place des Pleiades, 92415Courbevoie Cedex, France
JC Poignant
Affiliation:
IRIS, 6, place des Pleiades, 92415Courbevoie Cedex, France
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Summary

Repeated administrations of tianeptine (10 mg·kg-1 im, twice daily, for 15 days) did not globally influence sleep-wakefulness cycles and cortical EEG activity overnight in rhesus monkeys. This antidepressant agent neither inhibited paradoxical sleep nor increased slow wave sleep. However, tianeptine induced a slight, but significant increase in wakefulness during the first hour following its administration, and had no sedative effects. The influence of tianeptine on sleep patterns in the monkey could be related to other arousal or sleep modifications observed in rats and cats, and to certain electrophysiological data reported in rat studies.

Keywords

tianeptinesleep-wakefulness cyclerhesus monkeyantidepressant drug
Type
Original article
Information
European Psychiatry , Volume 8 , Issue 1 , 1993 , pp. 35 - 40
Copyright
Copyright © Elsevier, Paris 1993

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