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Effect of tianeptine on neuroendocrine, enzyme and behavioral responses to restraint stress in male rats

Published online by Cambridge University Press:  16 April 2020

R Fontanges ,
J Mimouni ,
X de Grieve ,
J Picard ,
M Pugeat  and
C Bange
R Fontanges
Affiliation:
Laboratoire de Physiologie cellulaire, Université Claude-Bernard, Lyon I, 69622Villeurbanne Cedex
J Mimouni
Affiliation:
Laboratoire de Physiologie cellulaire, Université Claude-Bernard, Lyon I, 69622Villeurbanne Cedex
X de Grieve
Affiliation:
Laboratoire de Physiologie cellulaire, Université Claude-Bernard, Lyon I, 69622Villeurbanne Cedex
J Picard
Affiliation:
Centre de Recherches du Service de Santé des Armées, 38702La Tranche Cedex
M Pugeat
Affiliation:
Laboratoire d'Endocrinologie, Université Claude-Bernard, Lyon I, hôpital de l‘Antiquaille, 69005Lyon
C Bange
Affiliation:
Laboratoire de Physiologie des Régulations, Université Claude-Bernard, Lyon I, 69622Villeurbanne Cedex, France
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Summary

The effects of the novel antidepressant tianeptine, after acute or chronic administration, were compared in normal and restraint-stressed (30 min or 2 h) Wistar rats. Tianeptine, at the dose of 10 mg/kg, did not exert any effect in non-stressed rats. However, in animals restrained for 30 min, tianeptine reduced the increase of circulating ACTH and β-endorphin levels without modification of corticosterone. Moreover, it antagonized the deficit of vertical exploratory activity in an open field. In rats restrained for 2 hours, a single injection of tianeptine suppressed the stress-induced increase of TAT hepatic activity and moderately attenuated the deficit of activity in the open field. This effect was less marked and not statistically significant after chronic treatment.

Keywords

stresstianeptineneuroendocrinologybehavior
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 67s - 73s
Copyright
Copyright © Elsevier, Paris 1993

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