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Diagnostic Interview for Genetic Studies (DIGS): Inter-rater and test-retest reliability and validity in a Spanish population

Published online by Cambridge University Press:  16 April 2020

Miguel Roca ,
Rocio Martin-Santos ,
Jerónimo Saiz ,
Jordi Obiols ,
Maria J. Serrano ,
Marta Torrens ,
Susana Subirà ,
Margalida Gili ,
Ricard Navinés  and
Angela Ibañez
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Miguel Roca*
Affiliation:
Hospital Joan March, University of Balearic Islands, Institut Universitari d'Investigació en Ciències de la Salut, Edifici Guillem Cifre, Carretera de Valldemossa km 7,5, 07122 Palma de Mallorca, Baleares, Spain
Rocio Martin-Santos
Affiliation:
Pharmacologic Research Unit, Institut Municipal d'Investigació Médica (IMIM) and Drug Abuse and Psychiatry Department (IAPS), Hospital Universitari del Mar, Barcelona
Jerónimo Saiz
Affiliation:
Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid
Jordi Obiols
Affiliation:
Unitat de Recerca en Psicopatologia i Neuropsicología, Facultat de Psicologia, Universitat Autónoma de Barcelona
Maria J. Serrano
Affiliation:
Hospital Joan March, University of Balearic Islands, Institut Universitari d'Investigació en Ciències de la Salut, Edifici Guillem Cifre, Carretera de Valldemossa km 7,5, 07122 Palma de Mallorca, Baleares, Spain
Marta Torrens
Affiliation:
Pharmacologic Research Unit, Institut Municipal d'Investigació Médica (IMIM) and Drug Abuse and Psychiatry Department (IAPS), Hospital Universitari del Mar, Barcelona
Susana Subirà
Affiliation:
Unitat de Recerca en Psicopatologia i Neuropsicología, Facultat de Psicologia, Universitat Autónoma de Barcelona
Margalida Gili
Affiliation:
Hospital Joan March, University of Balearic Islands, Institut Universitari d'Investigació en Ciències de la Salut, Edifici Guillem Cifre, Carretera de Valldemossa km 7,5, 07122 Palma de Mallorca, Baleares, Spain
Ricard Navinés
Affiliation:
Pharmacologic Research Unit, Institut Municipal d'Investigació Médica (IMIM) and Drug Abuse and Psychiatry Department (IAPS), Hospital Universitari del Mar, Barcelona
Angela Ibañez
Affiliation:
Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid
Marcos Nadal
Affiliation:
Hospital Joan March, University of Balearic Islands, Institut Universitari d'Investigació en Ciències de la Salut, Edifici Guillem Cifre, Carretera de Valldemossa km 7,5, 07122 Palma de Mallorca, Baleares, Spain
Nieves Barrantes
Affiliation:
Unitat de Recerca en Psicopatologia i Neuropsicología, Facultat de Psicologia, Universitat Autónoma de Barcelona
Francesca Cañellas
Affiliation:
Hospital Universitari Son Dureta, Universitat de les Illes Balears, Palma de Mallorca, Spain
*
*Corresponding author. Tel.: +34 971173267; fax: +34 971173190. E-mail address: [email protected] (M. Roca).
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Abstract

Objective

To test the reliability and validity of the DIGS in Spanish population.

Methods

Inter-rater and test-retest reliability of the Spanish version of DIGS was tested in 95 inpatients and outpatients. The resultant diagnoses were compared with diagnoses obtained by the LEAD (Longitudinal Expert All Data) procedure as “gold standard”. The kappa statistic was used to measure concordance between blind inter-raters and between the diagnoses obtained by LEAD procedure and through the DIGS.

Results

Overall kappa coefficient for inter-rater reliability was 0.956. The kappa value for individual diagnosis varied from major depression = 0.877 to schizophrenia = 1. Test-retest reliability was 0.926. Kappa for all individual target diagnoses ranged from 0.776 (major depression) to 1. Kappa between LEAD procedure and DIGS ranged from 0.704 (major depression) to 0.825 (bipolar I disorder).

Conclusion

Most of the DSM-IV major psychiatric disorders can be assessed with acceptable to excellent reliability with the Spanish version of the DIGS interview. The Spanish version of DIGS showed an acceptable to excellent concurrent validity. Giving the good reliability and validity of Spanish version of DIGS it should be considered to identify psychiatric phenotypes for genetics studies.

Keywords

DIGSGenetic studiesValidation
Type
Genetic Epidemiology and Its Methods
Information
European Psychiatry , Volume 22 , Issue 1 , January 2007 , pp. 44 - 48
Copyright
Copyright © Elsevier Masson SAS 2007

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