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Depression and monocyte dysfunction: a follow-up study

Published online by Cambridge University Press:  16 April 2020

S Cervera-Enguix  and
A Rodriguez-Rosado
S Cervera-Enguix
Affiliation:
Faculty of Medicine, Psychiatry and Medical Psychology Department, Universitary Hospital of the University of Navarra; Apartado 192, 31080Pamplona Navarra, Spain
A Rodriguez-Rosado
Affiliation:
Faculty of Medicine, Psychiatry and Medical Psychology Department, Universitary Hospital of the University of Navarra; Apartado 192, 31080Pamplona Navarra, Spain
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Summary

Several studies have reported immune cellular and humoral dysfunction during depression. We specifically focused on the study of the monocyte as it has a key role in the activation of the immune response. To examine the association between severity of depressive symptoms and values of monocyte parameters (HLA-DR, CD35, phagocytic activity and vimentin filaments), we used a longitudinal design and assessed monocyte markers at intake and at follow-up 12 weeks after discharge from the hospital in 49 depressed patients. Seventy percent of patients showed pretreatment a marked monocyte dysfunction (82.5% had at least one parameter altered). After treatment, alterations in immunological variables were significantly associated (P < 0.05) with depression scores higher than 15. The findings indicate that the monocyte dysfunction is temporally associated with the state of depression. Before and after treatment the immunoreactive vimentin filaments significantly increased (P < 0.01) after incubation of monocytes with naloxone, suggesting that an increased opioid activity might account for the monocyte dysfunction.

Keywords

depressionmonocyte dysfunction
Type
Original article
Information
European Psychiatry , Volume 9 , Issue 6 , 1994 , pp. 293 - 298
Copyright
Copyright © European Psychiatric Association 1994

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