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Comparison of brain N-acetylaspartate levels and serum brain-derived neurotrophic factor (BDNF) levels between patients with first-episode schizophrenia psychosis and healthy controls

Published online by Cambridge University Press:  16 April 2020

N. Goto ,
R. Yoshimura ,
S. Kakeda ,
J. Moriya ,
K. Hayashi ,
A. Ikenouchi-Sugita ,
W. Umene-Nakano ,
H. Hori ,
N. Ueda  and
Y. Korogi
...Show all authors
N. Goto
Affiliation:
Department of Psychiatry and Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan
R. Yoshimura*
Affiliation:
Department of Psychiatry and Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan
S. Kakeda
Affiliation:
Department of Psychiatry and Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan
J. Moriya
Affiliation:
Department of Psychiatry and Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan
K. Hayashi
Affiliation:
Department of Psychiatry and Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan
A. Ikenouchi-Sugita
Affiliation:
Department of Psychiatry and Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan
W. Umene-Nakano
Affiliation:
Department of Psychiatry and Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan
H. Hori
Affiliation:
Department of Psychiatry and Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan
N. Ueda
Affiliation:
Department of Psychiatry and Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan
Y. Korogi
Affiliation:
Department of Psychiatry and Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan
J. Nakamura
Affiliation:
Department of Psychiatry and Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan
*
*Corresponding author. Tel.: +8 19 36 91 72 53; fax: +8 19 36 92 48 94. E-mail address: [email protected] (R. Yoshimura).
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Abstract:

Background:

N-acetylaspartate (NAA) levels and serum brain-derived neurotrophic factor (BDNF) levels in patients with first-episode schizophrenia psychosis and age- and sex-matched healthy control subjects were investigated. In addition, plasma levels of homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) were compared between the two groups.

Method:

Eighteen patients (nine males, nine females; age range: 13–52 years) were enrolled in the study, and 18 volunteers (nine males, nine females; age range: 15–49 years) with no current or past psychiatric history were also studied by magnetic resonance spectroscopy (MRS) as sex- and age-matched controls.

Results:

Levels of NAA/Cr in the left basal ganglia (p = 0.0065) and parieto-occipital lobe (p = 0.00498), but not in the frontal lobe, were significantly lower in patients with first-episode schizophrenia psychosis than in control subjects. No difference was observed between the serum BDNF levels of patients with first-episode schizophrenia psychosis and control subjects. In regard to the plasma levels of catecholamine metabolites, plasma MHPG, but not HVA, was significantly lower in the patients with first-episode psychosis than in control subjects. In addition, a significantly positive correlation was observed between the levels of NAA/Cr of the left basal ganglia and plasma MHPG in all subjects.

Conclusions:

These results suggest that brain NAA levels in the left basal ganglia and plasma MHPG levels were significantly reduced at the first episode of schizophrenia psychosis, indicating that neurodegeneration via noradrenergic neurons might be associated with the initial progression of the disease.

Keywords

SchizophreniaN-acetylaspartateBrain-derived neurotrophic factor3-methoxy-4-hydroxyphenylglycolHomovanillic acid
Type
Original article
Information
European Psychiatry , Volume 26 , Issue 1 , January 2011 , pp. 57 - 63
Copyright
Copyright © Elsevier Masson SAS 2011

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