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Cardiovascular and metabolic risk in outpatients with schizoaffective disorder treated with antipsychotics: Results from the CLAMORS study

Published online by Cambridge University Press:  15 April 2020

J. Bobes ,
C. Arango ,
P. Aranda ,
R. Carmena ,
M. Garcia-Garcia ,
J. Rejas  and
on behalf of the CLAMORS Study Collaborative Group1
J. Bobes*
Affiliation:
Medicine Department, Psychiatry Area, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, C/Julián Clavería, 6, 33006Oviedo (Asturias), Spain
C. Arango
Affiliation:
Psychiatry Department, Hospital General Universitario Gregorio Marañón and Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain
P. Aranda
Affiliation:
Hypertension Unit, Carlos Haya Hospital, Málaga, Spain
R. Carmena
Affiliation:
Department of Endocrinology, Valencia University Clinic Hospital, Valencia, Spain
M. Garcia-Garcia
Affiliation:
Operations Department, Biometria Clinica CRO, Barcelona, Spain
J. Rejas
Affiliation:
Health Outcomes Research Department, Medical Unit, Pfizer España, Madrid, Spain
*
*Corresponding author. Tel.: +34 985 10 35 53; fax: +34 985 10 35 53. E-mail address: [email protected] (J. Bobes).
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Abstract

Aim

To assess the coronary heart disease (CHD) risk and prevalence of the metabolic syndrome (MS) in patients with schizoaffective disorder (SD) receiving antipsychotics.

Methods

Patients meeting DSM-IV criteria for SD and receiving antipsychotic treatment were recruited in a retrospective, cross-sectional, multicenter study (the CLAMORS study). MS was defined as at least three of the following components: waist circumference greater than 102cm (men)/greater than 88cm (women); serum triglycerides greater or equal to 150mg/dl; HDL cholesterol less than 40mg/dl (men)/less than 50mg/dl (women); blood pressure greater or equal to 130/85mmHg; fasting blood glucose greater or equal to 110mg/dl. The 10-year CHD risk was assessed by the Systematic coronary risk evaluation (SCORE) (cardiovascular mortality) and Framingham (any cardiovascular event) functions. Clinical severity was assessed using the PANSS and CGI-S scales.

Results

A total of 268 valuable patients with SD (127 men, 48.1%), 41.9±12.3years (mean±S.D.), were analyzed. The 10-year overall cardiovascular mortality and CV-event risk were 0.8±1.6 (SCORE) and 6.5±6.8 (Framingham), respectively. A high/very high risk of any CV event (Framingham≥10%) was associated with severity [CGI-S=3–4; OR: 4.32 (1.15–16.26), P = 0.03)]. MS was present in 26.5% (95%CI: 21.2–31.8) of subjects, without gender differences, but significantly associated with patient's impression of severity: CGI=3–4; OR=1.90 (0.83–4.36), and CGI=5–7; OR=3.13 (1.06–9.24), P = 0<0.001, and age [OR=1.91 (1.09–3.34), P<0.024)].

Conclusions

CHD risk and MS prevalence were high among patients with SD, being MS prevalence associated with age and severity of disease.

Keywords

Metabolic syndromeCardiovascular riskSchizoaffective disordersOutpatientsAntipsychotic treatmentMental status
Type
Original articles
Information
European Psychiatry , Volume 27 , Issue 4 , May 2012 , pp. 267 - 274
Copyright
Copyright © Elsevier Masson SAS 2012

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