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Bipolar disorder, schizoaffective disorder and schizophrenia: epidemiologic, clinical and prognostic differences

Published online by Cambridge University Press:  16 April 2020

A. Benabarre ,
E. Vieta ,
F. Colom ,
A. Martínez-Arán ,
M. Reinares  and
C. Gastó
A. Benabarre
Affiliation:
Clinical Institute of Psychiatry and Psychology, Department of Psychiatry, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain
E. Vieta*
Affiliation:
Clinical Institute of Psychiatry and Psychology, Department of Psychiatry, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain
F. Colom
Affiliation:
Clinical Institute of Psychiatry and Psychology, Department of Psychiatry, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain
A. Martínez-Arán
Affiliation:
Clinical Institute of Psychiatry and Psychology, Department of Psychiatry, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain
M. Reinares
Affiliation:
Clinical Institute of Psychiatry and Psychology, Department of Psychiatry, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain
C. Gastó
Affiliation:
Clinical Institute of Psychiatry and Psychology, Department of Psychiatry, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain
*
*Correspondence and reprints. E-mail address: [email protected] (E. Vieta).
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Summary

The validity and nosologic status of schizoaffective disorder is still a controversial issue. This study was conducted to analyze the demographic, clinical and prognostic variables that determine the validity of the diagnosis of schizoaffective disorder bipolar type. We analyzed and compared 138 outpatients: 67 with type I bipolar disorder, 34 with schizoaffective disorder bipolar type and 37 with schizophrenia. They were all diagnosed following research diagnostic criteria and assessed according to the Schedule for Affective Disorders and Schizophrenia. Schizoaffective unipolar patients were excluded. The results reaffirmed that, from the standpoints of demographics, clinical features and prognosis, schizoaffective disorders bipolar type can be classified as a phenotypic form at an intermediate point between bipolar I disorder and schizophrenia. These results emphasize the importance of longitudinal follow-up in the diagnosis and assessment of psychotic syndromes. Although cross-sectional symptoms were closer to the schizophrenia spectrum, the course of the illness resembled more that of bipolar patients, resulting in an intermediate outcome.

Keywords

bipolar disorderevolutionprognosisschizoaffective disorderschizophrenia
Type
Original article
Information
European Psychiatry , Volume 16 , Issue 3 , April 2001 , pp. 167 - 172
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2001

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