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BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

Published online by Cambridge University Press:  16 April 2020

G. Spalletta ,
D.W. Morris ,
F. Angelucci ,
I.A. Rubino ,
I. Spoletini ,
P. Bria ,
G. Martinotti ,
A. Siracusano ,
G. Bonaviri  and
S. Bernardini
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G. Spalletta
Affiliation:
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179Rome, Italy
D.W. Morris
Affiliation:
Neuropsychiatric Genetics Research Group, Dept of Psychiatry, Trinity College Dublin, Dublin2, Ireland
F. Angelucci*
Affiliation:
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179Rome, Italy
I.A. Rubino
Affiliation:
Department of Neuroscience, Tor Vergata University, Rome, Italy
I. Spoletini
Affiliation:
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179Rome, Italy
P. Bria
Affiliation:
Institute of Psychiatry, Catholic University, Rome, Italy
G. Martinotti
Affiliation:
Institute of Psychiatry, Catholic University, Rome, Italy
A. Siracusano
Affiliation:
Department of Neuroscience, Tor Vergata University, Rome, Italy
G. Bonaviri
Affiliation:
Sapienza University, Department of Neurology, Rome, Italy
S. Bernardini
Affiliation:
Department of Internal Medicine, Tor Vergata University, Rome, Italy
C. Caltagirone
Affiliation:
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179Rome, Italy
P. Bossù
Affiliation:
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179Rome, Italy
G. Donohoe
Affiliation:
Neuropsychiatric Genetics Research Group, Dept of Psychiatry, Trinity College Dublin, Dublin2, Ireland
M. Gill
Affiliation:
Neuropsychiatric Genetics Research Group, Dept of Psychiatry, Trinity College Dublin, Dublin2, Ireland
A.P. Corvin
Affiliation:
Neuropsychiatric Genetics Research Group, Dept of Psychiatry, Trinity College Dublin, Dublin2, Ireland
*
*Corresponding author. Tel.: +39 06 51501550; fax: +39 06 51501552. E-mail address: [email protected] (F. Angelucci).
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Abstract

Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.

Keywords

BDNFVal66MetPolymorphismAggressionSchizophrenia
Type
Psychiatric Genetics
Information
European Psychiatry , Volume 25 , Issue 6 , October 2010 , pp. 311 - 313
Copyright
Copyright © Elsevier Masson SAS 2010

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