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Association study of catechol-O-methyltransferase Val158Met polymorphism with personality traits in japanese healthy volunteers

Published online by Cambridge University Press:  30 August 2007

Genki ishii ,
Akihito Suzuki ,
Shingo Oshino ,
Hiroaki Shiraishi ,
Yoshihiko Matsumoto ,
Koichi Otani  and
Kaoru Goto
Genki ishii
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
Akihito Suzuki*
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
Shingo Oshino
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
Hiroaki Shiraishi
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
Yoshihiko Matsumoto
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
Koichi Otani
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
Kaoru Goto
Affiliation:
Department of anatomy and Cell Biology, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
*
∗Corresponding author. Tel.: +81 23 628 5322; fax: +81 23 628 5325. E-mail address: [email protected] (A. Suzuki).
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Abstract

Catechol-O-methyltransferase (COMT) is one of the major enzymes for the degradation of catecholamines. It has been suggested that catecholaminergic neurotransmission is involved in characterization of personality. Previous studies on the association between the COMT Val158Met polymorphism and personality traits in healthy subjects have produced inconsistent results. Therefore, the relationship between this polymorphism and personality was re-examined in 478 Japanese healthy volunteers. Personality traits were assessed by the Temperament and Character inventory (TCI), and the COMT genotypes were determined by a PCR-RFLP method. in total, there were no significant differences among the Val/Val, Val/Met, and Met/Met genotypes in seven TCI dimension scores. Similarly, no significant relationship was found between the COMT genotypes and the TCI dimensions when males and females were analyzed separately. The present study thus suggests that the COMT Val158Met polymorphism is not associated with personality traits in Japanese healthy subjects.

Keywords

Catechol-O-methyltransferase Val158Met polymorphismHealthy subjectsPersonalityTemperament and Character inventory
Type
Original article
Information
European Psychiatry , Volume 22 , Issue 7 , October 2007 , pp. 462 - 465
Copyright
Copyright © Elsevier Masson SAS 2007

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