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Are eye movement abnormalities indicators of genetic vulnerability to schizophrenia?

Published online by Cambridge University Press:  16 April 2020

C. Boudet ,
M.L. Bocca ,
B. Chabot ,
P. Delamillieure ,
P. Brazo ,
P. Denise  and
S. Dollfus
C. Boudet
Affiliation:
Groupe d'imagerie neurofonctionnelle (GIN), UMR 6194, CNRS/CEA/Université de Caen/Université Paris-V, centre Cyceron, boulevard H.-Becquerel, 14000Caen, France
M.L. Bocca
Affiliation:
Service d'explorations fonctionnelles, centre hospitalier et universitaire de Caen, 14033Caen cedex, France
B. Chabot
Affiliation:
Centre Esquirol, centre hospitalier et universitaire de Caen, 14033Caen, France
P. Delamillieure
Affiliation:
Groupe d'imagerie neurofonctionnelle (GIN), UMR 6194, CNRS/CEA/Université de Caen/Université Paris-V, centre Cyceron, boulevard H.-Becquerel, 14000Caen, France Centre Esquirol, centre hospitalier et universitaire de Caen, 14033Caen, France
P. Brazo
Affiliation:
Groupe d'imagerie neurofonctionnelle (GIN), UMR 6194, CNRS/CEA/Université de Caen/Université Paris-V, centre Cyceron, boulevard H.-Becquerel, 14000Caen, France Centre Esquirol, centre hospitalier et universitaire de Caen, 14033Caen, France
P. Denise
Affiliation:
Service d'explorations fonctionnelles, centre hospitalier et universitaire de Caen, 14033Caen cedex, France
S. Dollfus*
Affiliation:
Groupe d'imagerie neurofonctionnelle (GIN), UMR 6194, CNRS/CEA/Université de Caen/Université Paris-V, centre Cyceron, boulevard H.-Becquerel, 14000Caen, France Centre Esquirol, centre hospitalier et universitaire de Caen, 14033Caen, France
*
*Corresponding author. E-mail address: [email protected] (S. Dollfus).
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Abstract

Fifty to eighty-five percent of schizophrenic patients are impaired on ocular pursuit paradigms. However, results regarding the relatives are more discordant. The aim of this study was to investigate whether eye movement disorders could be a vulnerability marker of schizophrenia.

Method

Twenty-one schizophrenic patients (DSM-IV), 31 first-degree relatives of those patients without schizophrenic spectrum disorders, and two groups of healthy controls matched by age and sex were included. Three oculomotor tasks (smooth pursuit, reflexive saccades and antisaccades) were used.

Results

Patients had a lower averaged gain (P = 0.035) during smooth pursuit than controls, made less correct visually guided saccades (P < 0.001) and more antisaccades errors (P = 0.002) than controls. In contrast, none of the comparison between the relatives and their controls was significant.

Conclusions

Schizophrenic patients were impaired on smooth pursuit and antisaccade paradigms. None of these impairments was, however, observed in their first-degree relatives. Our results suggest that the eye movement parameters tested could not be considered as vulnerability markers for schizophrenia.

Keywords

SchizophreniaRelativesSmooth pursuit eye movementsSaccadesAntisaccadesGeneticsAge effect
Type
Original article
Information
European Psychiatry , Volume 20 , Issue 4 , June 2005 , pp. 339 - 345
Copyright
Copyright © Elsevier SAS 2005

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References

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed Washington DC: APA; 1994.Google Scholar
Bahill, AT, McDonald, JDFrequency limitations and optimal step size for the two-point central difference derivative algorithm with applications to human eye movement data. IEEE Trans Biomed Eng 1983;30(3):191–194.CrossRefGoogle ScholarPubMed
Ban, TADrug in schizophrenia. Can Psychiatr Assoc J 1971;16:473–485.CrossRefGoogle Scholar
Blackwood, DHR, St Clair, DM, Muir, WJ, Duffy, JCAuditory and eye-tracking dysfunction in schizophrenic pedigrees. Arch Gen Psychiatry 1991;48:899–909.CrossRefGoogle ScholarPubMed
Calkins, ME, Iacono, WG, Curtis, CESmooth pursuit and antisaccade performance evidence trait stability in schizophrenia patients and their relatives. Int J Psychophysiol 2003;49(2):139–146.CrossRefGoogle ScholarPubMed
Calkins, ME, Katsanis, J, Hammer, MA, Iacono, WGThe misclassification of blinks as saccades: implications for investigations of eye movement dysfunction in schizophrenia. Psychophysiology 2001;38:761–767.CrossRefGoogle Scholar
Chouinard, G, Ross-Chouinard, A, Annable, L, Jones, BDExtrapyramidal Symptom Rating Scale. Can J Neurol Sci 1980;7:233Google Scholar
Clementz, BA, McDowell, JE, Zisook, SSaccadic system functioning among schizophrenia patients and their first-degree biological relatives. J Abnorm Psychol 1994;103(2):277–287.CrossRefGoogle ScholarPubMed
Crawford, TJ, Haeger, B, Kennard, C, Reveley, MA, Henderson, LSaccadic abnormalities in psychotic patients. I. Neuroleptic-free psychotic patients. Psychol Med 1995;25:461–471.CrossRefGoogle ScholarPubMed
Crawford, TJ, Sharma, T, Puri, BK, Murray, RM, Berridge, DM, Lewis, SWSaccadic eye movements in families multiply affected with schizophrenia: the maudsley family study. Am J Psychiatry 1998;155:1703–1710.CrossRefGoogle ScholarPubMed
Curtis, CE, Calkins, ME, Iacono, WGSaccadic disinhibition in schizophrenia patients and their first-degree biological relatives. A parametric study of the effects of increasing inhibitory load. Exp Brain Res 2001;137:228–236.CrossRefGoogle ScholarPubMed
Denise, P, Darlot, C, Ignatiew-Charles, P, Toupet, MUnilateral peripheral semicircular canal lesion and off-vertical axis rotation. Acta Otolaryngol (Stockh) 1996;116:361–367.CrossRefGoogle ScholarPubMed
Diefendorf, AR, Dodge, RAn experimental study of ocular reactions of the insare from photographic records. Brain 1908;31:451–489.CrossRefGoogle Scholar
Endicott, J, Spitzer, RLA diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 1978;35:837–844.CrossRefGoogle Scholar
Flechtner, K.-M., Steinacher, B, Sauer, R, Mackert, ASmooth pursuit eye movements of patients with schizophrenia and affective disorder during clinical treatment. Eur Arch Psychiatry Clin Neurosci 2002;252:49–53.CrossRefGoogle ScholarPubMed
Foster, PNeuroleptic equivalence. Pharmacol J 1989;243:431–432.Google Scholar
Friedman, L, Jesberger, JA, Meltzer, HYEffect of typical antipsychotic medications and clozapine on smooth pursuit performance in patients with schizophrenia. Psychiatry Res 1991;41:25–36.CrossRefGoogle Scholar
Fukushima, J, Fukushima, K, Chiba, T, Tanaka, S, Yamashita, I, Kato, MDisturbances of voluntary control of saccadic eye movements in schizophrenia patients. Biol Psychiatry 1988;23:670–677.CrossRefGoogle Scholar
Fukushima, J, Fukushima, K, Morita, N, Yamashita, IFurther analysis of the control of voluntary eye movements in schizophrenic patients. Biol Psychiatry 1990;28:943–958.CrossRefGoogle ScholarPubMed
Fukushima, J, Morita, N, Fukushima, K, Chiba, T, Tanaka, S, Yamashita, IVoluntary control of saccadic eye movements in patients with schizophrenic and affective disorders. J Psychiatry Res 1990;24:9–24.CrossRefGoogle ScholarPubMed
Gooding, DCAntisaccade task performance in questionnaire-identified schizotypes. Schizophr Res 1999;35:157–166.CrossRefGoogle ScholarPubMed
Green, JF, King, DJ, Trimble, KMAntisaccade and smooth pursuit eye movements in healthy subjects receiving sertraline and lorazepam. J Psychopharmacol 2000;14(1):30–36.CrossRefGoogle ScholarPubMed
Holzman, PS, Proctor, LRK, Hughes, DWEye-tracking patterns in schizophrenia. Science 1973;181:179–181.CrossRefGoogle Scholar
Holzman, PS, Proctor, LR, Levy, DL, Yasillo, NJ, Meltzer, HY, Hurt, SWEye-tracking dysfunctions in schizophrenic patients and their relatives. Arch Gen Psychiatry 1974;31:143–151.CrossRefGoogle ScholarPubMed
Holzman, PS, Levy, DL, Uhlenhuth, EH, Proctor, LR, Freedman, DXSmooth-pursuit eye movements, and diazepam, CPZ, and secobartital. Psychopharmacologia (Berl) 1975;44:111–115.CrossRefGoogle Scholar
Hutton, SB, Crawford, TJ, Puri, BK, Duncan, LJ, Chapman, M, Kennard, Cet al.Smooth pursuit and saccadic abnormalities in first-episode schizophrenia. Psychol Med 1998;28:685–692.CrossRefGoogle ScholarPubMed
Karoumi, B, Ventre-Dominey, J, Dalery, JIntérêt de l'étude des antisaccades chez les schizophrènes. Ann Psychiatry 1996;11(4):238–243.Google Scholar
Karoumi, B, Saoud, M, d'Amato, T, Rosenfeld, F, Denise, P, Gutknecht, Cet al.Poor performance in smooth pursuit and antisaccadic eye-movement tasks in healthy siblings of patients with schizophrenia. Psychiatry Res 2001;101:209–219.CrossRefGoogle ScholarPubMed
Karson, CN, Goldberg, TE, Leleszi, JPIncreased blink rate in adolescent patients with psychosis. Psychiatr Res 1986;17:195–198.CrossRefGoogle ScholarPubMed
Kathmann, N, Hochrein, A, Uwer, R, Bondy, BDeficits in gain of smooth pursuit eye movements in schizophrenia and affective disorder patients and their unaffected relatives. Am J Psychiatry 2003;160:696–702.CrossRefGoogle ScholarPubMed
Kay, SR, Fiszbein, A, Opler, LAThe Positive And Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull 1987;13(2):261–276.CrossRefGoogle Scholar
Keefe, RSE, Silverman, JM, Mohs, RC, Siever, LJ, Harvey, PD, Friedman, Let al.Eye-tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia. Arch Gen Psychiatry 1997;54:169–176.CrossRefGoogle ScholarPubMed
Kremen, WS, Tsuang, MT, Faraone, SV, Lyons, MJUsing vulnerability indicators to compare conceptual models of genetic heterogeneity in schizophrenia. J Nerv Ment Dis 1992;180(3):141–152.CrossRefGoogle Scholar
Küfferle, B, Friedmann, A, Topitz, A, Földes, P, Anderer, P, Kutzer, Met al.Smooth pursuit eye movements in schizophrenia: influences of neuroleptic treatment and the question of specificity. Psychopathology 1990;23:106–114.CrossRefGoogle ScholarPubMed
Larrison, AL, Ferrante, CF, Briand, KA, Sereno, ABSchizotypal traits, attention and eye movements. Prog Neuropsychopharmacol Biol Psychiatry 2000;24:357–372.CrossRefGoogle ScholarPubMed
Lee, KH, Williams, LMEye movement dysfunction as a biological marker of risk for schizophrenia. Aust New Zealand J Psychiatry 2000;34(Suppl):S91–S100.CrossRefGoogle ScholarPubMed
Lee, KH, Williams, LM, Loughland, CM, Davidson, DJ, Gordon, ESyndromes of schizophrenia and smooth-pursuit eye movement dysfunction. Psychiatry Res 2001;101:11–21.CrossRefGoogle ScholarPubMed
Lencer, R, Malchow, CP, Krecker, K, Nolte, A, Pinnow, M, Zimmerman, Set al.Smooth pursuit performance in families with multiple occurrence of schizophrenia and nonpsychotic families. Biol Psychiatry 1999;45:694–703.CrossRefGoogle ScholarPubMed
Lencer, R, Malchow, CP, Trillenberg-Krecker, K, Schwinger, E, Arolt, VEye-tracking dysfunction (ETD) in families with sporadic and familial schizophrenia. Biol Psychiatry 2000;47:391–401.CrossRefGoogle ScholarPubMed
Levy, DL, Holzman, PS, Matthysse, S, Mendell, NREye-tracking dysfunction and schizophrenia: a critical perspective. Schizophr Bull 1993;19(3):461–535.CrossRefGoogle ScholarPubMed
Litman, RE, Hommer, DW, Radant, A, Clem, T, Pickar, DQuantitative effects of typical and atypical neuroleptics on smooth pursuit eye-tracking in schizophrenia. Schizophr Res 1994;12:107–120.CrossRefGoogle Scholar
Litman, RE, Fuller Torrey, E, Hommer, DW, Radant, AR, Pickar, D, Weinberger, DRA quantitative analysis of smooth pursuit eye-tracking in monozygotic twins discordant for schizophrenia. Arch Gen Psychiatry 1997;54:417–426.CrossRefGoogle Scholar
Loranger, AW, Sartorius, N, Andreoli, A, Berger, P, Buchheim, P, Channabasavanna, SMet al.The World Health Organization. The International Personality Disorder Examination. Alcohol, drug abuse, and Mental Health Administration, international pilot study of personality disorder. Arch Gen Psychiatry 1994;51(3):215–224.CrossRefGoogle ScholarPubMed
Mackert, A, Woyth, C, Flechtner, K.-M., Volz, H.-P.Increased blink rate in drug-naïve acute schizophrenic patients. Biol Psychiatry 1990;27:1197–1202.CrossRefGoogle ScholarPubMed
Munoz, DP, Broughton, JR, Goldring, JE, Armstrong, ITAge-related performance of human subjects on saccadic eye movement tasks. Exp Brain Res 1998;121:391–400.CrossRefGoogle ScholarPubMed
Nkam, I, Thibaut, F, Denise, P, van der Elst, A, Ségard, L, Brazo, Pet al.Saccadic and smooth-pursuit eye movements in deficit and non-deficit schizophrenia. Schizophr Res 2001;48:145–153.CrossRefGoogle ScholarPubMed
O'Driscoll, GA, Lenzenweger, MF, Holzman, PSAntisaccades and smooth pursuit eye-tracking and schizotypy. Arch Gen Psychiatry 1998;55:837–843.CrossRefGoogle ScholarPubMed
Ross, DE, Thaker, GK, Buchanan, RW, Lahti, AC, Medoff, D, Bartko, JJet al.Association of abnormal pursuit eye movements with the deficit syndrome in schizophrenic patients. Am J Psychiatry 1996;153:1158–1165.Google ScholarPubMed
Ross, RG, Harris, JG, Olincy, A, Radant, A, Adler, LE, Freedman, RFamilial transmission of two independent saccadic abnormalities in schizophrenia. Schizophr Res 1998;30:59–70.CrossRefGoogle Scholar
Ross, RG, Olincy, A, Radant, A, Adler, LE, Compagnon, N, Friedman, RThe effects of age on a smooth pursuit tracking task in adults with schizophrenia and normal subjects. Biol Psychiatry 1999;46:383–391.CrossRefGoogle ScholarPubMed
Schwartz, BD, O'Brien, BA, Evans, WJ, Sautter, FJ, Winstead, DKSmooth pursuit eye movement differences between familial and non-familial schizophrenia. Schizophr Res 1995;17:211–219.CrossRefGoogle ScholarPubMed
Sereno, AB, Holzman, PSAntisaccades and smooth pursuit eye movements in schizophrenia. Biol Psychiatry 1995;37(6):394–401.CrossRefGoogle Scholar
Sharpe, JA, Sylvester, TOEffect of aging on horizontal smooth pursuit. Invest Ophthal Visual Sci 1978;17(5):465–468.Google ScholarPubMed
Sweeney, JA, Haas, GL, Li, S, Weiden, PJSelective effects of antipsychotic medications on eye-tracking performance in schizophrenia. Psychiatry Res 1994;54(2):185–198.Google Scholar
Thaker, GK, Kirkpatrick, B, Buchanan, RW, Ellsberry, R, Lahti, A, Tamminga, COculomotor abnormalities and their clinical correlates in schizophrenia. Psychopharmacolo bull 1989;25:491–497.Google Scholar
Thaker, GK, Cassady, S, Adami, H, Moran, M, Ross, DEEye movements in spectrum personality disorders: comparison of community subjects and relatives of schizophrenic patients. Am J Psychiatry 1996;153(3):362–368.Google ScholarPubMed
Thaker, GK, Ross, DE, Cassady, SL, Adami, HM, Medoff, DR, Sherr, JSaccadic eye movement abnormalities in relatives of patients with schizophrenia. Schizophr Res 2000;45:235–244.CrossRefGoogle ScholarPubMed
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