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Anxiolytic and hypnotic use in 376 psychiatric inpatients

Published online by Cambridge University Press:  16 April 2020

P. Hardy ,
C. Payan ,
J.C. Bisserbe ,
J.P. Lepine  and
GERMED Neuropsychotropics Group
P. Hardy
Affiliation:
Department of Psychiatry, Department of Psychiatry, Centre Hospitalo-Universitaire de Bicêtre, 78, rue du Général-Leclerc, 94275 Le Kremlin Bicêtre, France
C. Payan
Affiliation:
Délégation à la Recherche Clinique, Assistance Publique - Hôpitaux de ParisParis, France
J.C. Bisserbe
Affiliation:
INSERM U302, Pitié-Salpêtrière Hospital Paris, France
J.P. Lepine*
Affiliation:
Department of Psychiatry, Fernand Widal Hospital Paris, France
*
*The GERMED (Groupe d'Étude et de Recherche sur le Médicament) Neuropsychotropics group is a department of the Assistance Publique – Hôpitaux de Paris. Steering committee: Prof. Widlöher, Prof. Fermanian, Prof. Puech, Prof. Singlas. Centres and investigators: Albert Chenevier hospital (Prof. Manus, Dr. Rauzy, Dr. Montfort, Dr. Recasens, Dr. De Brettes), Bicetre Hospital (Prof. Feline, Prof. Hardy, Dr. De Mont–Marin, Dr. Drouet, Dr. Monnet, Dr. N'guyen, Ms. Gres), Bichat Hospital (Prof. Ades, Prof. Lepine, Dr. Teodorescu), Corentin Celton Hospital (Dr. De Praingy, Dr. Beaufils, Dr. Amalric), Louis Mourier Hospital (Prof. Ades, Prof. Rouillon, Dr. Leon, Dr. Lejoyeux, Dr. Chignon, Ms. Tassain), Laennec Hospital (Prof. Debray, Dr. Edy, Dr. Jacquemin, Dr. Abillon), Paul–Brousse Hospital (Prof. Ginestet, Dr. Vindreau, Dr. Ferrand, Dr. Garcon, Dr. Oreve–Mauratille, Dr. Bernard, Dr. Esvan, Dr. Rauzy), Richaud Hospital (Prof. Chevalier, Dr. Plas, Dr. Lefrere, Dr. Fallet, Dr. Bessac), Saint–Antoine Hospital (Prof. Ferreri, Dr. Radat, Dr. Elatki, Ms.. Berteaux), Sainte–Anne Hospital (Prof. Lôo, Dr. Poirier–Littre, Dr. Weiss, Dr. Jobert), Salpetriere Hospital (Prof. Widlöcher, Dr. Claudel, Ms. Lebrand, Ms. Asseraf). Coordination and Monitoring: Dr. Chaumet–Riffaud, Ms. Pizzato.
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Summary

This objectives of this study were three-fold: retrospectively evaluate anxiolytic/hypnotic consumption by psychiatric inpatients, identify the risk factors of prolonged intakes, and prospectively measure the impact of hospitalisation on the use of those drugs. Three hundred and seventy-six patients hospitalised in 11 psychiatric departments in the Paris region were studied using a structured interview for the anxiolytic/hypnotic treatments, DSM-III-R criteria, GHQ-12, HAD, Spiegel's questionnaire, COVI's anxiety scale and the CGI. Eighty-five per cent of the patients had taken one anxiolytic/hypnotic or more in the 3 months preceding hospitalisation. Hospitalisation induced little change in anxiolytic/hypnotic use: dosage frequency increased from 77% to 84% between the week preceding hospitalisation and that preceding discharge; 26% of consumers were taking at least two anxiolytics or two hypnotics in the first period vs. 23% in the second. The absence of withdrawal during hospitalisation was related to the high age and a diagnosis of depression rather than schizophrenia, to the existence of continuous intake over the 3 months preceding hospitalisation and to higher drug doses during the 7 days preceding hospitalisation. Prescription of treatment at the end of hospitalisation in previously non-user subjects was related to a higher HAD anxiety score at discharge.

Keywords

anxiolyticshypnoticsbenzodiazepinesdependencechronic usepsychiatric inpatients
Type
Original article
Information
European Psychiatry , Volume 14 , Issue 1 , March 1999 , pp. 25 - 33
Copyright
Copyright © Elsevier, Paris 1999

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