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Antinuclear antibodies in schizophrenia and major depressive disorder — a lasting puzzle

Published online by Cambridge University Press:  16 April 2020

K Schott ,
A Uhl ,
A Batra ,
M Bartels ,
B Eusterschulte  and
G Buchkremer
K Schott
Affiliation:
Universitätsklinik für Psychiatrie und Psychotherapie, Osianderstrasse 22, D-72076Tübingen, Germany
A Uhl
Affiliation:
Universitätsklinik für Psychiatrie und Psychotherapie, Osianderstrasse 22, D-72076Tübingen, Germany
A Batra
Affiliation:
Universitätsklinik für Psychiatrie und Psychotherapie, Osianderstrasse 22, D-72076Tübingen, Germany
M Bartels
Affiliation:
Universitätsklinik für Psychiatrie und Psychotherapie, Osianderstrasse 22, D-72076Tübingen, Germany
B Eusterschulte
Affiliation:
Fachklinik Rottenmünster, Schwenningerstrasse 35, D-78628Rottweil, Germany
G Buchkremer
Affiliation:
Universitätsklinik für Psychiatrie und Psychotherapie, Osianderstrasse 22, D-72076Tübingen, Germany
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Summary

Sera from patients with major depressive disorder and paranoid schizophrenia were screened for antinuclear antibodies (antigens: ds-DNA, ENA, histone H3) and circulating immune complexes (CIC-Cq1) by ELISA. Controls were healthy blood donors. Only a few of the patients' sera were positive for anti-ds-DNA and anti-ENA antibodies. There was no significant result. In paranoid schizophrenia 20.5% of sera were positive for antibodies against histone H3. In the case of CIC-Cql, 7% of the patients with major depressive disorder and 11 % of those with paranoid schizophrenia were positive. Controls showed positive sera in 39%. This study disagrees with former studies which could demonstrate a series of antinuclear antibodies in mental disorders. In the case of antihistone antibodies, the present results could indicate an autoimmune process in a subgroup of schizophrenic patients.

Keywords

antinuclear antibodieshistonesmajor depressive disorderschizophrenia
Type
Short communication
Information
European Psychiatry , Volume 11 , Issue 5 , 1996 , pp. 263 - 267
Copyright
Copyright © Elsevier, Paris 1996

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