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Antidepressant effect of 5-methoxypsoralen: the melatonin synchronizer hypothesis

Published online by Cambridge University Press:  16 April 2020

G Darcourt ,
P Feuillade ,
Y Bistagnin ,
P Robert ,
D Pringuey ,
M Touari ,
Y Merdji  and
B Bensmaïl
G Darcourt
Affiliation:
Clinique de Psychiatrie et de Psychologie Médicale, Faculté de Médecine, Hôpital Pasteur, 130, avenue de la Voie Romaine, BP 69, 06002Nice Cedex 01, France
P Feuillade
Affiliation:
Clinique de Psychiatrie et de Psychologie Médicale, Faculté de Médecine, Hôpital Pasteur, 130, avenue de la Voie Romaine, BP 69, 06002Nice Cedex 01, France
Y Bistagnin
Affiliation:
Clinique de Psychiatrie et de Psychologie Médicale, Faculté de Médecine, Hôpital Pasteur, 130, avenue de la Voie Romaine, BP 69, 06002Nice Cedex 01, France
P Robert
Affiliation:
Clinique de Psychiatrie et de Psychologie Médicale, Faculté de Médecine, Hôpital Pasteur, 130, avenue de la Voie Romaine, BP 69, 06002Nice Cedex 01, France
D Pringuey
Affiliation:
Clinique de Psychiatrie et de Psychologie Médicale, Faculté de Médecine, Hôpital Pasteur, 130, avenue de la Voie Romaine, BP 69, 06002Nice Cedex 01, France
M Touari
Affiliation:
Clinique de Psychiatrie, Faculté de Médecine, Constantine, Algeria
Y Merdji
Affiliation:
Clinique de Psychiatrie, Faculté de Médecine, Constantine, Algeria
B Bensmaïl
Affiliation:
Clinique de Psychiatrie, Faculté de Médecine, Constantine, Algeria
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Summary

5-methoxypsoralen (5-MOP) stimulates pineal melatonin secretion, and a decrease in dark phase melatonin levels has been described in major depression. As exogenous melatonin has shown synchronizer properties, authors hypothesized that giving 5-MOP would have antidepressant properties.

Twenty-six inpatients meeting the criteria of major depressive disorders were enrolled in a four-week, double blind trial of 5-MOP versus amitriptyline. Clinical improvement was identical in both treatment groups but biological changes were different in each group: 5-MOP patients showed an early nocturnal surge of melatonin levels that was maintained at the fourth treatment week, while melatonin levels remained unchanged in patients treated with amitriptyline.

Keywords

depression5-methoxypsoralenamitriptylinemelatonincortisolbiological rhythms
Type
Original article
Information
European Psychiatry , Volume 10 , Issue 3 , 1995 , pp. 142 - 154
Copyright
Copyright © Elsevier, Paris 1995

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References

American Psychiatric Association DSMIII-R: Diagnostic and Statistical Manual of Mental Disorders. 3rd ed. rev. København: American Psychiatric Association, 1987Google Scholar
Arato, MGrof, EGrof, PLaszlo, IBrown, GMReproductibility of the overnight melatonin secretion pattern in healthy men. In: Brown, GMWainwright, SD eds. The pineal endocrine aspects, advances in the Biosciences Oxford and New York: Pergamon Press, 1985; 53 277–82Google Scholar
Arendt, JWirz-Justice, ALongterm studies on imunoreactive human melatonin. Ann Clin Biochem 1979; 16: 307–12CrossRefGoogle Scholar
Arendt, JAldhous, MMarks, VAlleviation of jet lag by melatonin: preliminary results of controlled double blind trial. Br Med J 1986; 292: 1170–4CrossRefGoogle ScholarPubMed
Axelrod, JThe pineal gland: a neurochemical transducer. Science 1974; 184: 1341–8CrossRefGoogle ScholarPubMed
Backstrom, MWetterberg, LInfluence of psoralen on melatonin formation in rat pineal gland in organ culture. Acta Endocrinol 1977; 86: 659–66CrossRefGoogle ScholarPubMed
Beck-Friis, JKjellman, BFAperia, Fet al.Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrom Acta Psychiatr Scand 1985; 71 319–30CrossRefGoogle Scholar
Birau, NSchloots, WPathological nycthemeral of melatonin secretion in psoriasis, Klinefelter's syndrome and spina bifida. IRCS Medical Science 1979; 7: 400Google Scholar
Birau, NMelatonin in human serum. Progress in screening investigation and clinic. In: Birau, NSchloots, W eds. Melatonin current status and perspectives. Oxford: Pergamon Press, 1981; 297CrossRefGoogle Scholar
Blask, DEHill, SMMelatonin and cancer: basic and clinical aspects. In: Miles, APhilbrick, DRSThomson, C eds. Melatonin Clinical Perspectives. Oxford Medical Publication, 1989; 128–65Google Scholar
Boyce, PM6-sulphathoxymelatonin in melancholia. Am J Psychiatry 1985; 142: 125–7Google Scholar
Branchey, LWeinberg, UBranchey, MLinkowski, PMendlewicz, JSimultaneous study of 24-hour patterns of melatonin and cortisol in depressed patients. Neuropsychobiology 1982; 8: 225–32CrossRefGoogle ScholarPubMed
Brotman, AWFalk, WEGelenberg, AJPharmacologic treatment of acute depressive subtypes. In: Meltzer, HY eds. Psychopharmacology: the Third Generation of Progress Raven Press 1987; 1031–8Google Scholar
Brown, RPKocsis, JHCaroff, Set al.Differences in melatonin secretion between melancholic depressed patients and control subjects Am J Psychiatry 1985; 142: 811–6Google ScholarPubMed
Carman, JSPost, RMBuswell, RGoodwin, FKNegative effets of melatonin on depression. Am J Psy 1976; 133: 1181–6Google Scholar
Carney, MPWRoth, MGarside, RFThe diagnosis of depressive syndromes and the prediction of ECT response. Br J Psychiatry 1965; 111: 659–74CrossRefGoogle Scholar
Carney, MWPSheffield, BFDepression and the Newcastle scales. Their relationship to Hamilton's scale. Br J Psychiatry 1972; 121: 35–40CrossRefGoogle ScholarPubMed
Cassone, VMClesworth, MJArmstrong, SMEntrainment of rat circadian rhythms by daily injection of melatonin depends upon the hypothalamic suprachiasmatic nuclei. Physiology and Behaviour 1986; 36: 1111CrossRefGoogle ScholarPubMed
Chazot, GClaustrat, BBrun, JOlivier, Rapid antidepressant activity of destyr gamma endorphin. Correlations with urinary melatonin. Biol Psychiatry 1985; 20: 1026–30CrossRefGoogle Scholar
Checkley, SAPalazidou, EMelatonin and antidepressant drugs: clinical pharmacology. In: Miles, APhilbrick, DRSThomson, C eds. Melatonin Clinical Perspectives. Oxford Medical Publication, 1989; 190–201Google Scholar
Claustrat, BChazot, GBrun, JJordan, DSassolas, GA chronobiological study of melatonin and cortisol secretion in depression subjects: plasma melatonin, a biochemical marker in major depression. Biol Psychiatry 1984; 19: 1215–28Google ScholarPubMed
Claustrat, BBrun, JGarry, PRoussel, BSassolas, GA once repeated study of nocturnal plasma melatonin patterns and sleep recordings in six normal young men. Journal of Pineal Research 1986; 3: 301–10CrossRefGoogle ScholarPubMed
Cowen, PJFraser, SSammons, RGreen, ARAtenolol reduces plasma melatonin concentration in man. Br J Clin Pharmacology 1983; 15: 579–81CrossRefGoogle ScholarPubMed
Ferrier, INArendt, JJohnstone, ECCrow, TJReduced normal melatonin secretion in chronic schizophrenia: relationship to body weight. Clinical Endocrinology (Oxford) 1982; 17: 181–7CrossRefGoogle Scholar
Fleiss, JLThe design and analysis of clinical experiments New york: Wiley 1986Google Scholar
Frazer, ABrown, RKocsis, Jet al.Patterns of melatonin rhythms in depression J Neural Transmiss 1986; 21 (Suppl): 269–90Google ScholarPubMed
Grota, LJLewy, AJGoldsmith, LABrown, MPsoralen increases melatonin levels without ultraviolet. Ann NY Acad Sci 1985; 453: 385CrossRefGoogle Scholar
Halbreich, VAsinis, GMSchinlecker, RZunoff, BNathan, SCortisol secretion in endogenous depression. Arch Gen Psychiatry 1985; 42: 904–14CrossRefGoogle ScholarPubMed
Hamilton, MDevelopment of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967; 6: 278–96CrossRefGoogle ScholarPubMed
Hansen, THeyden, TSundberg, IWetterberg, LEffect of propanolol on serum melatonin. Lancet 1977; 2: 309CrossRefGoogle Scholar
Honingsman, HPsoralen photochemotherapy: mechanisms drugs toxicity. Curr Probl Dermatol 1986; 15: 52–66CrossRefGoogle Scholar
Iguichi, HKato, KIIbayaschi, HAge-dependent reduction in serum melatonin concentrations in healthy human subjects. J Clin Endocrinol Metab 1982; 55: 27–9CrossRefGoogle ScholarPubMed
Klein, DCThe pineal gland: a model of neuro-endocrine regulation. In: Reichlin, SBaldassari, RJMartin, JB eds. The hypothalamus. New York: Raven Press, 1978; 303–27Google Scholar
Klein, DCAuerbach, DANambodiiri, MAWheler, GHTIndole metabolism in the mammalian pineal gland. In: Reiter, RJ eds. The pineal gland. Boca Raton, Florida: CRC Press, 1981Google Scholar
Kripke, DFMullaney, DJAtkinson, MHuey, LYHubbarb, ECircadian rhythm phases in affective illness. Chronobiologia 1979; 6: 7Google Scholar
Lang, UAubert, MLConne, BSBradke, JCSizonenko, PCInfluence of exogenous melatonin on melatonin secretion and the neuroendocrine reproductive axis in intact male rats during sexual maturation. Endocrinology 1983; 112: 1578CrossRefGoogle ScholarPubMed
Lewy, AJWehr, TAGoodwin, FKNewsome, DAMarkey, SPLight suppresses melatonin secretion in humans. Science 1980; 210: 1267–9CrossRefGoogle ScholarPubMed
Lewy, AJHuman melatonin secretion: a marker for adrenergic function. In: Post, RMBallanger, JC eds. Neurobiology of mood disorders. Baltimore, Maryland: Williams and Wilkins, 1984; 215–26Google Scholar
Lewy, AJSack, RLSinger, CLAssessment and treatment of chronobiological disorders using plasma melatonin levels and bright light exposure: the clock-gate model and the phase response curve. Psychopharmacol Bull 1984; 20: 561–5Google Scholar
Lewy, AJNurnberger, JIWehr, TAet al.Supersensitivity to light: a possible trait-marker for manic depressive illness Am J Psychiatry 1985a; 142: 725–8Google ScholarPubMed
Lewy, AJSack, RLSinger, CMTreating phase-typed chronobiological sleep and mood disorders using appropriately timed artificial light. Psychopharmacol Bull 1985b; 21: 368–72Google Scholar
Lewy, AJSack, RLMelatonin physiology and light therapy. Clin Neuropharmacol 1986; (Suppl) 4: 196–8Google Scholar
Lewy, AJSiever, LJUhde, TWMarkey, SPClonidine reduces plasma melatonin levels. J Pharm Pharmacology 1986; 38: 555–6CrossRefGoogle ScholarPubMed
Lieberman, HRLea, AEMelatonin: effects on sleep and behaviour in man. In: Miles, APhilbrick, DRSThomson, C eds. Melatonin Clinical Perspectives. Oxford Medical Publication, 1989; 118–26Google Scholar
Linkowski, PMendlewicz, JLeclercq, RThe 24 hour profile of adrenocorticotropin and cortisol in major depressive illness. J Clin Endocrinol Metab 1985; 61: 429CrossRefGoogle ScholarPubMed
Lynch, HJWurtman, RJMoskowitz, MAArcher, MCHo, MHDaily rhythm in human urinary melatonin. Science 1975; 187: 169–71CrossRefGoogle ScholarPubMed
Lynch, HLBrzezinski, ADeng, MHLieberman, HRWurtman, RJEffect of behavioural and physiological variables on melatonin secretion in humans. In: Reiter, RJFraschini, F eds. Advances in pineal research John Libbey & Co Ltd. 1987 181–90Google Scholar
Mendlewicz, JLinkowski, PBranchey, LAbnormal 24 h pattern of melatonin secretion in depression. Lancet 1979; 12: 1362CrossRefGoogle Scholar
Miles, APhilbrick, DRSMelatonin and psychiatry, a review. Biol Psychiatry 1988; 23: 405–25CrossRefGoogle Scholar
Minneman, KPWurtman, RJEffects of pineal compounds on mammals life. Life Sci 1975; 17: 1189–200CrossRefGoogle Scholar
Montgomery, SAAsberg, MA new depression scale designed to be sensitive to change. Br J Psychiatry 1979; 134: 382–9Google ScholarPubMed
Moore, RYCentral neural control of circadian rhythms. Front Neuroendocrinol 1978; 5: 185–206Google Scholar
Moore, DCPaunier, LSizonenko, PCEffect of adrenergic stimulation and blockade on melatonin secretion in the human. Progress in Brain Research 1979; 52: 517–21Google ScholarPubMed
Nair, VNPet al.Effect of Lithium on circadian rhythm of plasma melatonin in normal men IRCS Med Sci 1984; 12 854–5Google Scholar
Papousek, MChronobiologische aspekte der zyklothymie. Forsche Neuro Psychiatr 1975; 43: 381–440Google Scholar
Parrish, JAFitzpatrick, TBTanenbaum, LPathak, MAPhotochemotherapy of psoriasis with oral methoxypsoralem and long-wave ultraviolet light. New Engl J Med 1974; 291: 1207CrossRefGoogle Scholar
Quay, WBCircadian and estrous rhythms in pineal melatonin and 5-hydroxyindole-3-acetic acid Proceedings of the Society for Experimental Biology and Medicine 1964; 115 710–3CrossRefGoogle Scholar
Quay, WBPineal chemistry CC Thomas Press 1974Google Scholar
Redman, JArmstrong, SFree running activity rhythm in the rat: entrainment by melatonin. Science 1983; 219: 1080CrossRefGoogle ScholarPubMed
Reiter, RJSorrentino, SInhibition of luteinizing hormone release and ovulation in PMS-treated rat by peripherally administered melatonin. Contraception 1971; 4: 385–92CrossRefGoogle Scholar
Reppert, SMWeaver, DRRivkees, SAStoppa, EGPutative melatonin receptors in a human biological clock. Science 1988; 242: 78–81CrossRefGoogle Scholar
Rosenthal, et al.Atenolol in seasonal affective disorder: a test of the melatonin hypothesis Am J Psychiatry 1988; 145: 52–6Google ScholarPubMed
Sachar, EJHellman, LRoffwang, HPGallagher, TFDisrupted 24 hour patterns of cortisol secretion in psychotic depression. Arch Gen Psychiatry 1973; 28: 19CrossRefGoogle ScholarPubMed
Sack, RLLewy, AJMelatonin and major affective disorders. In: Miles, APhilbrick, DRSThomson, C eds. Melatonin Clinical Perspectives. Oxford Medical Publication, 1989; 205–21Google Scholar
Schildkraut, UThe catecholamine hypothesis of affective disorders, a review of supporting evidence. Am J Psychiatry 1965; 122: 509–12Google ScholarPubMed
Shaw, KMStein, GMSandler, MMelatonin and Parkinsonnism. Lancet 1973; 1: 271CrossRefGoogle Scholar
Song, PSTapley, KJPhotochemistry and photobiology of psoralens. Photochem Photobiol 1979; 29: 1177–97CrossRefGoogle ScholarPubMed
Souêtre, ESalvati, EBelugou, JLet al.5-Metoxypsoralen increase the plasma melatonin levels in human The journal of investigative dermatology 1987; 89 152–5CrossRefGoogle Scholar
Souêtre, ESalvati, ELacour, JCet al.Psoralen and the suppression of melatonin secretion by bright light Photochem Photobiol 1988a; 47: 579–81CrossRefGoogle ScholarPubMed
Souêtre, ETamarkin, LSalvati, EPacciotti, GKrebs, BDarcourt, G Stimulating effect of 5-methoxypsoralen on the secretion of melatonin Third International Conference of Chronopharmacology 1988b, Nice March 14–17, 1988Google Scholar
Souêtre, ESalvati, EBelugou, JLRobert, PBrunet, GDarcourt, GAntidepressant effect of 5-methoxypsoralen: a preliminary report. Psychopharmacology 1988c; 9: 430–1Google Scholar
Souêtre, ESalvati, ECandito, MDarcourt, GCircadian rhythms in depressed and recovery: evidence for the blunted amplitude hypothesis. Psychiatry Res 1989a; 28: 263–79CrossRefGoogle Scholar
Souêtre, ESalvati, EBelugou, JLKrebs, BDarcourt, G5-Methoxypsoralen increases evening sleepness in humans: possible involvement of the melatonin secretion. Eur J Clin Pharmacol 1989; 36: 91–2CrossRefGoogle Scholar
Souêtre, EDe Galeani, BGastaud, PSalvati, EDarcourt, G5-Methoxypsoralen increases the sensitivity of the retina to light in humans. Eur J Clin Pharmacol 1989c; 36: 59–61CrossRefGoogle ScholarPubMed
Souêtre, ESalvati, EKrebs, BBelugou, JLDarcourt, GAbnormal melatonin response to 5-Methoxypsoralen in dementia. Am J Psychiatry 1989; 146: 1037–40Google ScholarPubMed
Steiner, Brown, The Pineal Gland: Endocrine Aspects. In: Brown, Vainwright, eds. Advances in Biosciences Oxford: PergamonPress 1985; 347–53Google Scholar
Sulser, FVetulani, JMobley, PLMode of action of antidepressant drugs. Biochemical Pharmacology 1978; 27: 257–53CrossRefGoogle ScholarPubMed
Sulser, FRegulation and function of noradrenalin receptor systems in brain. Psychopharmacological aspects. Neuropharmacology 1984; 23: 255–61CrossRefGoogle ScholarPubMed
Tamarkin, LCohen, MRoselle, DMelatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenzalphaan-thracene-induced mammary tumors in the rat. Cancer Res 1981; 41: 4432–6Google ScholarPubMed
Tamarkin, LBaird, CJAlmeida, OFXMelatonin: a coordinating signal for mammalian reproduction?. Science 1985; 227: 714–20CrossRefGoogle ScholarPubMed
Thomson, et al.A comparison of melatonin secretion in depressed patients and normal subjects Br J Psychiatry 1988; 152: 260–5CrossRefGoogle Scholar
Underwood, HThe pineal and circadian rhythms. In: Reiter, RJ eds. The Pineal Gland. New York: Raven Press, 1984; 221–51Google Scholar
Waldhauser, FSteiger, HVorkapic, PMelatonin secretion in man and the influence of exogenous melatonin on some physiological and behavioural variables. In: Reiter, RJFraschini, F eds. Advances in pineal research. John Libbey & Co Ltd, 1987; 207–21Google Scholar
Wehr, TAGoodwin, FK Biological Rhythms and Psychiatry. In: Arieti, SBrodie, H eds. American Handbook of Psychiatry 1980; vol VIIGoogle Scholar
Wehr, TALewy, AJWirz-Justice, ACraig, CTamarkin, LAntidepressants and a circadian rhythm phase-advance hypothesis of depression. In: Collu, RDucharme, RJBarbeau, ATolis, G eds. Brain Peptides and Hormones New York: Raven Press 1982; 263Google Scholar
Wehr, TAWirz-Justice, ACircadian rhythms mechanisms in affective illness and in antidepressant drug action. Pharmacopsychiatry 1982; 15: 31–9CrossRefGoogle ScholarPubMed
Wetterberg, LMelatonin in humans: physiological and clinical studies. J Neural Transmission 1978; (Suppl) 13: 289–310Google Scholar
Wetterberg, LBeck-Friis, JAperia, BPeterson, UMelatonin/Cortisol ratio in depression. Lancet 1979; ii: 1361Google Scholar
Wetterberg, LMelatonin as a chronobiological marker in health and disease. In: Axelrod, JFraschini, FVolvo, GP eds. The pineal gland and its endocrine role. New York: Plenum Publishing Corporation, 1983; 575–87Google Scholar
Wetterberg, LBeck-Friis, JKjellman, BKLjunggren, JGCircadian rhythms in melatonin and cortisol secretion in depression. In: Usdin, Eet al.Frontiers in Biochemical and Pharmacological Research in Depression. New York: Raven Press, 1984; 197–204Google Scholar
Wever, RPhase shifts of human circadian rhythms due to shifts of artificial zeitgebers. Chronobiologia 1980; 7: 303Google ScholarPubMed
Widlöcher, DL'échelle de ralentissement dépressif, fondement théorique et premières applications. Psychol Med 1981; 13B: 53–60Google Scholar
Widlöcher, DLe ralentissement. Paris: PUF (collection Nodules), 1983Google Scholar
Wolff, FAThomas, TVClinical pharmacokinetics of methoxalen and other psoralens. Clin Pharmacokinet 1986; 11: 62–5CrossRefGoogle Scholar
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