Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-05T02:32:55.986Z Has data issue: false hasContentIssue false

Aberrant Functional Connectivity Within and Across the Default Mode, Central-executive, and Salience Network in Patients with Schizophrenia: a Resting-state FMRIi Study

Published online by Cambridge University Press:  15 April 2020

H.L. Wang
Affiliation:
Department of Psychiatry, Renmin Hospital Of Wuhan University, Wuhan, China
H. Huang
Affiliation:
Department of Psychiatry, Renmin Hospital Of Wuhan University, Wuhan, China
C. Chen
Affiliation:
Department of Psychiatry, Renmin Hospital Of Wuhan University, Wuhan, China
P.F. Li
Affiliation:
Department of Psychiatry, Renmin Hospital Of Wuhan University, Wuhan, China
Y. Zhou
Affiliation:
Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology Chinese Academy of Sciences, Beijing, China
T.Z. Jiang
Affiliation:
LIAMA Center for Computational Medicine National Laboratory of Pattern Recognition, nstitute of Automation Chinese Academy of Sciences, Beijing, China

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Objective

To explore the feature of functional connectivity of default mode network (DMN), central-executive network(CEN), and salience network (SN) in patients with schizophrenia during a resting state by functional magnetic resonance imaging (fMRI).

Methods

The SPM8, DPARSFA, conn, REST softwares combined with data-driven region of interest analysis were used to compare the functional connectivity (FC) of the DMN, CEN, and SN in 74 patients with schizophrenia(SZ) and 79 age- and gender-matched normal controls(NC). Medial prefrontal cortex(MPFC)was selected as seed region for identifying DMN and CEN; right anterior insula(rAI) for SN.

Results

Compared with NC, SZ showed increased FC with bilateral dorsolateral prefrontal cortex(DLPFC) and bilateral putamen of the MPFC, and increased FC with left middle frontal cortex and precuneus/ posterior cingulate cortex(Pcu/PCC) of the rAI. SZ also showed enhanced interconnectivity strengths of CEN-DMN, CEN-SN, and DMN-SN(p>0.05). Correlation analyses showed that the increased FC between MPFC and left DLPFC significantly negatively correlated with PANSS-negative symptoms(r=-0.224,p=0.030) and increased FC between rAI and Pcu/PCC significantly correlated with PANSS-positve symptoms (r=0.243,p=0.020).

Conclusion

This study provides evidence for resting state functional abnormalities of DMN, CEN, and SN in schizophrenia patients. These aberrant functional connectivities in some key brain regions of the three network could be responsible for the schizophrenic symptoms.

Type
Article: 0253
Copyright
Copyright © European Psychiatric Association 2015
Submit a response

Comments

No Comments have been published for this article.