Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-30T00:48:30.623Z Has data issue: false hasContentIssue false
  • English
  • Français

1438 – Default Mode Network In Left-sided Temporal Lobe Epilepsy Patients With And Without Comorbid Affective Disorders

Published online by Cambridge University Press:  15 April 2020

L. Shmeleva ,
A. Lebedev  and
M. Kissin
L. Shmeleva
Affiliation:
Psychiatry, Saint-Peterburg State I.Pavlov Medical Univercity, Saint-Petersburg, Russia
A. Lebedev
Affiliation:
Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway
M. Kissin
Affiliation:
Psychiatry, Saint-Peterburg State I.Pavlov Medical Univercity, Saint-Petersburg, Russia

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Affective disorders are common in patients with temporal lobe epilepsy, especially in cases of left-sided epileptic focus localization (lsTLE).

Aim

To characterize connectivity patterns of brain default mode network (DMN) in lsTLE patients with and without anxiety and depressive disorders.

Subjects and methods

28 lsTLE patients, divided into two groups: patients with (“affective” group) and without anxiety- depressive symptoms. Beck Depression Inventory (BDI), Hospital Anxiety Depressive Scale (HADS), Hamilton Anxiety Scale (HAM-A) and Montgomery-Asberg Depressive Rating Scale (MADRS) were used to assess affective symptoms. All subjects underwent 9-min resting-state fMRI scanning session. Independent component analysis (ICA) was used to isolate DMN. The resulted maps were compared in groups using two-sample t-test. The results were considered as statistically significant according to threshold of p < 0.005 with a 10-voxel extent that has recently been shown to produce an optimal balance between Types I and II error rates in fMRI studies (Lieberman, 2009). The data were processed and analyzed using SPM8 and “GIFT” toolbox for ICA “GIFT”.

Results

Mild depression and moderate-severe anxiety levels were observed in the "affective" group. Significantly increased functional connectivity was found in “affective” group in the right cerebellum (culmen), right gyrus fusiformis, dorsolateral prefrontal and midcingulate area, and in the left insula.

Conclusions

We found that brain DMN is altered by affective disorders associated with lsTLE. The observed regional pattern of difference can reflect the impaired levels of self-control often present in lsTLE patients with affective symptoms

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E758
Copyright
Copyright © European Psychiatric Association 2013
Submit a response

Comments

No Comments have been published for this article.