To examine incidence ofand factors associated with metabolic syndrome in patients with majordepressive disorder within a year.

All majordepressive disorder (MDD)patients who visited our psychiatric clinic were screened. All subjects were screenedby the metabolic syndrome criteria proposed by the American Heart Association/National Heart, Lung, and BloodInstitute (updated ATPIII). Subjects who did not meet the criteria of metabolicsyndrome would come after one year to screen for it again. Age and history ofused atypical antipsychotic use, duration of illness, severity of illness andfamily history of metabolic syndrome were assessed as factors associated withthe metabolic syndrome. Data was analyzed by using percentage, mean, standarddeviations, student t-test, chi-square test and Fisher's exact test.

There were 140 subjectsrecruited. 53 were excluded because they had metabolic syndrome. After one year77 of 87 came to the follow up visit for screening metabolic syndrome. The1-year incidence of metabolic is 16.9%(13 subjects) and 11.7%(9 subjects) dueto ATP III and IDF criteria respectively. Triglyceride and HDL at baseline wassignificantly associated with metabolic syndrome in patients with majordepressive disorder (p≤0.001). Age andhistory of used atypical antipsychotic use, duration of illness, severity ofillness and family history of metabolic were not associated with metabolicsyndrome.

Thai MDD patients are likely to have and developmetabolic syndrome. These findings support the importance of assessing andmonitoring metabolic syndrome in MDD patients especially in patients who havehigh triglyceride and HDL.