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Una revisión sistemática de la eficacia y la seguridad de los antipsicóticos de segunda generación en el tratamiento de la manía

Published online by Cambridge University Press:  12 May 2020

R. M. Jones ,
C. Thompson  and
I. Bitter
R. M. Jones
Affiliation:
Grupo de Salud Mental, Universidad de Southampton, Southampton, Reino Unido
C. Thompson
Affiliation:
Grupo de Salud Mental, Universidad de Southampton, Southampton, Reino Unido
I. Bitter
Affiliation:
Operaciones Regionales E. Lilly, Viena, Austria Departamento de Psiquiatría y Psicoterapia, Universidad Semmelweis, Budapest, Hungría
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Resumen

Los agentes antipsicóticos de segunda generación se utilizan cada vez más en el tratamiento de la manía aguda. Se realizó una revisión sistemática de la eficacia y la seguridad de estos agentes, tanto en monoterapia como en combinación con estabilizadores del estado de ánimo, para establecer los datos para su uso. Los ensayos controlados distribuidos al azar (ECDA) se valoraron críticamente con más detalle que los estudios que presentaban niveles más bajos de datos, como los informes clínicos, las series clínicas y los estudios de seguimiento al descubierto. Encontramos 11 ECDA que informaban sobre pacientes tratados con antipsicóticos de segunda generación para la manía bipolar aguda, tres de los cuales incluían distribución al azar entre el antipsicótico de segunda generación y el placebo, y ocho entre un estabilizador del estado de ánimo combinado con el antipsicótico de segunda generación o el placebo. Se presentan también datos de ensayos no distribuidos al azar.

Keywords

ManíaTrastorno bipolarSegunda generaciónAntipsicóticoEficaciaSeguridad
Type
Revisión
Information
European Psychiatry (Ed. Española) , Volume 13 , Issue 5 , June 2006 , pp. 217 - 226
Copyright
Copyright © European Psychiatric Association 2006

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