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Niveles de globulina fijadora de cortisol en el trastorno bipolar

Published online by Cambridge University Press:  12 May 2020

E. Vieta ,
C. Gastó ,
M. J. Martínez de Osaba ,
A. Otero ,
E. Nieto ,
L. Pintor ,
J. Blanch  and
J. Vallejo
E. Vieta
Affiliation:
Departamento de Psiquiatría
C. Gastó
Affiliation:
Departamento de Psiquiatría
M. J. Martínez de Osaba
Affiliation:
Laboratorio Hormonal, Hospital Clínico, Universidad de Barcelona
A. Otero
Affiliation:
Departamento de Psiquiatría
E. Nieto
Affiliation:
Departamento de Psiquiatría, Hospital de Manresa, Manresa
L. Pintor
Affiliation:
Departamento de Psiquiatría
J. Blanch
Affiliation:
Departamento de Psiquiatría
J. Vallejo
Affiliation:
Departamento de Psiquiatría, Hospital de Bellvitge, Universidad de Barcelona
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Resumen

La globulina fijadora de cortisol (CBG) es una glucoproteína-alfa-1 con elevada afinidad al cortisol que podría ser un potencial marcador biológico del estrés crónico, según varios estudios anteriores. Para examinar las concentraciones de CBG en el trastorno bipolar, determinamos sus niveles en suero por radioinmunoensayo con anticuerpos monoclonales en una muestra de 39 pacientes con trastorno bipolar I en remisión según los RDC y 21 sujetos de control sanos emparejados por la edad, el sexo y el peso corporal. Sólo se permitió el tratamiento de litio. Se determinaron también los niveles de cortisol en plasma y de litio en suero. Los hombres bipolares mostraron niveles de CBG en suero significativamente menores que los controles, mientras que las mujeres mostraron valores muy similares. No se encontró correlación entre los niveles de CBG y las concentraciones de cortisol o litio. Se concluye que la enfermedad afectiva crónica afecta a los niveles de CBG, incluso durante los períodos de remisión, al menos en los hombres bipolares.

Keywords

trastorno bipolarglobulinaCortisoltranscortinalitio
Type
Artículo Original
Information
European Psychiatry (Ed. Española) , Volume 4 , Issue 6 , September 1997 , pp. 375 - 380
Copyright
Copyright © European Psychiatric Association 1997

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Footnotes

Vieta E, Gastó C, Martínez de Osaba MJ, Otero A, Nieto E, Pintor L, Blanch J, Vallejo J. Cortisol-binding globulin levels in bipolar disorder. Eur Psychiatry 1997; 12: 11-15.

References

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