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La prueba de supresión con dexametasona y los diagnósticos del DSM-III-R en personas que han intentado suicidarse

Published online by Cambridge University Press:  12 May 2020

Åsa Westrin ,
Karin Frii  and
Lil Träskman-Bendz
Åsa Westrin
Affiliation:
División de Psiquiatría, Departamento de Neurociencia Clínica, Universidad de Lund, 22185Lund, Suecia
Karin Frii
Affiliation:
División de Psiquiatría, Departamento de Neurociencia Clínica, Universidad de Lund, 22185Lund, Suecia
Lil Träskman-Bendz
Affiliation:
División de Psiquiatría, Departamento de Neurociencia Clínica, Universidad de Lund, 22185Lund, Suecia
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Resumen

Propósito:

Investigaciones anteriores sobre la actividad del eje hipotálamo-hipófiso-suprarrenal (HPA) en personas que han intentado suicidarse han mostrado resultados contrapuestos. El propósito del presente estudio era examinar la influencia de los trastornos de personalidad y los diagnósticos concomitantes del eje I en la prueba diagnóstica de supresión con dexametasona utilizando análisis de regresión múltiple. La muestra constaba de 184 pacientes con un intento de suicidio reciente y 42 controles sanos. Como se esperaba, las concentraciones de cortisol pre- y posdexametaxona más bajas se encontraron en los pacientes con trastornos de la personalidad del eje II, grupo B, comparado con los demás pacientes. Los resultados fueron significativos cuando se analizaron para la covarianza con los diagnósticos del eje I del DSM-III-R, la edad o el sexo. Queda por esclarecer si estas concentraciones bajas de cortisol se deben a la experiencia anterior de acontecimientos estresantes extremos o una carga duradera, o si pueden ser consecuencia de una predisposición biogenética o psicológica de interés. Es preciso examinar con más detenimiento la comorbilidad del eje I.

Keywords

trastorno de la personalidadtrastorno depresivointentos de suicidiosistema hipófiso-suprarrenalcortisol
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 11 , Issue 1 , February 2004 , pp. 38 - 45
Copyright
Copyright © European Psychiatric Association 2004

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