Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-23T23:03:01.171Z Has data issue: false hasContentIssue false
  • English
  • Français

Investigatión cerebral de hermanos sanos de pacientes esquizofrénicos

Published online by Cambridge University Press:  12 May 2020

A. Mourot ,
T. d'Amato ,
T. Rochet ,
M. Marie-Cardine ,
C. Artéaga ,
J. P. Martin  and
J. Dalery
A. Mourot
Affiliation:
CHS de Saint-Avé, 56890Saint-Avé
T. d'Amato
Affiliation:
CHS le Vinatier, 69677Bron
T. Rochet
Affiliation:
CHS le Vinatier, 69677Bron
M. Marie-Cardine
Affiliation:
CHS le Vinatier, 69677Bron
C. Artéaga
Affiliation:
Hôpital d'Instruction des Armées de Desgenettes, 69003Lyon, Francia
J. P. Martin
Affiliation:
Hôpital d'Instruction des Armées de Desgenettes, 69003Lyon, Francia
J. Dalery
Affiliation:
CHS le Vinatier, 69677Bron
Get access

Resumen

Los estudios de tomografía computerizada (TC) han demostrado que el tamaño de los ventrículos laterales medido por la proporción ventrículo-cerebro (PVC), así como la anchura del tercer ventrículo, son estadísticamente mayores en los pacientes esquizofrénicos. Además, estas anomalías cerebrales difieren según los síntomas valorados con una escala de síntomas positivos y negativos. El propósito de este estudio era investigar, utilizando exploraciones de TC, a hermanos sanos de pacientes esquizofrénicos y relacionar los resultados con sus hermanos enfermos. Diecinueve hermanos sanos de 12 esquizofrénicos que habían sido estudiados con anterioridad sufrieron exploraciones de TC, que se compararon con las de su hermano esquizofrénico y con 17 sujetos de control no relacionados. Los resultados mostraron que, en 10 de las 12 familias, los esquizofrénicos tienen ventrículos (laterales y tercero) más grandes que sus hermanos sanos. La dilatatión ventricular de los hermanos sanos estaba correlacionada con la gravedad de los síntomas negativos de su hermano enfermo. Se debaten las implicaciones de una contributión familiar al tamaño ventricular y los síntomas negativos.

Keywords

exploración de TCproporción ventrículo-cerebrotercer ventrículoesquizofreniasíntomas negativos
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 5 , Issue 1 , February 1998 , pp. 36 - 42
Copyright
Copyright © European Psychiatric Association 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bibliografia

d'Amato, TRochert, TDalery, JLaurent, AJChauchat, JHTerra, JL et al. X-ray. Relationship between symptoms rated with the positive and negative syndrome scale and brain measures in schizophrenia. Brain Res 1992; 44: 55–62.Google Scholar
Andreasen, NCOlsen, S. Negative vs positive schizophrenia: definition and validation. Arch Gen Psychiatry 1982; 39: 789–94.CrossRefGoogle Scholar
Andreasen, NCOlsen, SDennert, JWSmith, MR.Ventricular enlargement in schizoprenia: relationship to positive and negative symptoms. Am J Psychiatry 1982; 139: 297–302.Google Scholar
Andreasen, NCSwayze, VWFlaum, MYates, WRArndt, SMcChesney, C. Ventricular enlargement in schizoprenia evaluated with computed tomographic scanning: effects of gender, age, and stage of illness. Arch Gen Psychiatry 1990; 47: 1008-15.CrossRefGoogle Scholar
American Psychiatric Association (APA). DSM-III-R: Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, revised. Washington, DC: APA, 1987.Google Scholar
Bertelsen, AGottesman, II, Offspring of twin pairs discordant for psychiatric illness. Acta Genet Med Gemellol (Rome) 1986; 35: 310.Google Scholar
Borntein, RASchwartzkopf, SBOlson, SCNasrallah, HA. Third-ventricle enlargement and neuropsychological deficit in schizophrenia. Biol Psychiatry 1992; 31:954-61.CrossRefGoogle Scholar
Crow, TJ. Positive and negative schizophrenic symptoms and the role of dopamine. Br J Psychiatry 1980; 137: 383-6.CrossRefGoogle ScholarPubMed
Degreef, GAshtari, MWu, HWBorenstein, MGeisler, SLieberman, J. Follow up MRI study in first episode schizophrenia. Schizophr Res 1991; 5: 204-6.CrossRefGoogle ScholarPubMed
Delisi, LEGoldin, LRHamovit, JRMaxwell, MEKurtz, DGershon, E. A family study of the association of increased ventricular size with schizophrenia. Arch Gen Psychiatry 1986; 43: 48–53.CrossRefGoogle ScholarPubMed
Delisi, LEStrizke, PRiordan, HHolan, VBoccio, AKushner, M et al. The timing of brain morphological changes in schizophrenia and their relationship to clinical outcome. Biol Psychiatry 1992; 31: 241–54.CrossRefGoogle ScholarPubMed
Farmer, AJackson, RMcGuffin, P. Cerebral ventricular enlargement in chronic schizophrenics: consistencies and contradictions. Br J Psychiatry 1987; 150: 324-30.CrossRefGoogle ScholarPubMed
Fyer, AJEndicott, JMannuzza, SKlein, DF. Schedule for Affective Disorders and Schizophrenia - Life time Anxiety Version. New York: New York State Psychiatric Institute, 1985.Google Scholar
Illowsky, BJuliano, DBigelow, LWeinberger, DR. Stability of CT scan findings in schizophrenia: results of a 8 year follow up study. J Neurol Neurosurg Psychiatry 1988; 51: 209–13.CrossRefGoogle ScholarPubMed
Kaiya, HUematsu, MOfuli, MNishida, AMorikyo, MAdaschi, S. Computerized tomography in schizophrenia: familial versus non-familial froms of illness. Br J Psychiatry 1990; 155: 444–50.CrossRefGoogle Scholar
Kay, SRFiszbein, AOpler, LA. The positive and negative dimension syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13: 261–76.CrossRefGoogle Scholar
Keilp, JGSweeney, JAJacobsen, PSolomon, C, St Louis, LDeck, M et al. Cognitive impairement in schizophrenia: specific relations to ventricular size and negative symptomatology. Biol Psychiatry 1988; 24: 47–55.CrossRefGoogle Scholar
Kendler, KSGruenberg, AMTsuang, MT. A family study of the subtypes of schizophrenics. Am J Psychiatry 1988; 145: 57–62.Google Scholar
Klausner, JDSweeey, JADeck, MDFHass, GLKelly, AB. Clinical correlates of cerebral ventricular enlargement in shizophrenia. J Nerv Ment Dis 1992; 180: 407–12.CrossRefGoogle Scholar
Kringlen, ECramer, G. Offspring of monozygotic twins discordant for schizophrenia. Arch Gen Psychiatry 1989; 46: 873-7.CrossRefGoogle Scholar
Laffey, PA. Computed tomography and aging; results in a normal elderly population. Neuroradiology 1984; 26: 273-8.Google Scholar
Leboyer, MFilteau, MJJay, MCampion, Dd'Amato, TGuilloud-Bataille, M et al. Clinical subtypes and age at onset in schizophrenic siblings. Psychiatry Res 1992; 41: 107–14.CrossRefGoogle ScholarPubMed
Lewis, SW. Computerised tomography in schizophrenia 15 years on. Br J Psychiatry 1990; 157 (9): 16–24.CrossRefGoogle Scholar
Moscareli, MCesana, BMCiusami, S. Ventricle-brain ratio and alogia in 19 young patients with chronic negative and positive schizophrenia. Am J Psychiatry 1989; 146: 257-8.Google Scholar
Nasrallah, HAOlson, SCMcColley-Whitters, MChapman, S; Jacoby, CG. Cerebral ventricular enlargement in schizophrenia. Arch Gen Psychiatry 1986; 43: 157-9.CrossRefGoogle Scholar
Olbiols Llandrich, JERuscalleda, JMasferrer, M. Ventricular enlargement in young chronic schizophrenics. Acta Psychiatr Scand 1986; 73:42-4.CrossRefGoogle Scholar
Owen, DGCJohnstone, ECCrow, TJFrith, CDJagoe, JRKreel, I. Lateral ventricular size in schizophrenia: relationship to the disease process and its clinical manifestations. Psychol Med 1985; 15: 27–41.CrossRefGoogle Scholar
Ota, TMaeshiro, HIshido, HShimizu, YUchida, RToyoshima, ROhsima, H et al. Treatment-resistant chronic psychopathology and CT scans in schizophrenia. Acta Psychiatr Scand 1987; 75: 415–27.CrossRefGoogle Scholar
Pearlson, GDGarbacz, DJBreakey, WRAhn, HSDepaulo, JR. Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both Schizophrenia and Bipolar Disorder. Psychiatry Res 1984; 12: 1–19.CrossRefGoogle ScholarPubMed
Reveley, AMReveley, MAMurray, Rm, Clifford, CA. Cerebral ventricular size in twins discordant for schizophrenia. Lancet 1982; I: 540-1.CrossRefGoogle Scholar
Reveley, AMReveley, MAMurray, RM. Cerebral ventricular enlargement in non-genetic schizophrenia: a controlled twin study. Br J Psychiatry 1984; 144: 89–93.CrossRefGoogle ScholarPubMed
Schulz, SCRoller, MMKishore, PRHamer, RMGehl, JJFriedel, RO. Ventricular enlargement in teenage patients with schizophrenia spectrum disorder. Am J Psychiatry 1983; 140: 1592-5.Google ScholarPubMed
Torrey, EF. Are we overestimating the genetic contribution to schizophrenia? Schizophr Bull 1992; 18: 159–70.CrossRefGoogle Scholar
Van Dorn, JDMcManus, IC. Ventricular enlargement in schizophrenia, a meta-analysis of studies enlargement in schzophrenia, a meta-analysis of studies of the ventricle brain ratio (VBR). Br J Psychiatry 1992; 160: 687–97.CrossRefGoogle Scholar
Vita, A. Cerebral ventricular abnormalities in schizophrenia: evidence of their early origin and stability over time. Schizophr Res 1992; 5: 189–90.CrossRefGoogle Scholar
Weinberger, DR. Premorbid neuropathology in schizophrenia. Lancet 1988; II: 660-9.Google Scholar
Weinberger, DRDelisi, LNeophytides, ANWyatt, RJ. Familial aspects of CT scan abnormalities in chronic schizophrenic patients. Psychaitry Res 1981; 4: 65–71.CrossRefGoogle ScholarPubMed
Williams, AOReveley, MAKolakowska, TArden, MMandelbrote, BM. Schizophrenia with good and poor outcome: cerebral ventricular size and its clinical correspondance. Br J Psychiatry 1985; 146: 239–46.CrossRefGoogle Scholar
Young, AHBlackwood, DHRRoxborough, HMcQueen, JKMartín, MJKean, D. A magnetic resonance imaging study of schizophrenia brain structure and clinical symtoms. Br J Psychiatry 1991; 158: 158–64.CrossRefGoogle Scholar
Zipursky, RBKelvin, OLSullivan, EDBrown, BWPfefferbaum, A. Widespread cerebral gray matter volume deficits in schizophrenia. Arch Gen Psychiatry 1992; 49: 195–205.CrossRefGoogle Scholar