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Evolución de los pacientes en la esquizofrenia II: el impacto de la cognicién

Published online by Cambridge University Press:  12 May 2020

Alex Hofer ,
Susanne Baumgartner ,
Thomas Bodner ,
Monika Edlinger ,
Martina Hummer ,
Georg Kemmler ,
Maria A. Rettenbacher  and
W. Wolfgang Fleischhacker
Alex Hofer
Affiliation:
Departamento de Psiquiatría Biológica, Universidad Médica de Innsbruck, Anichstrasse 35, A-6020Innsbruck, Austria
Susanne Baumgartner
Affiliation:
Departamento de Psiquiatría Biológica, Universidad Médica de Innsbruck, Anichstrasse 35, A-6020Innsbruck, Austria
Thomas Bodner
Affiliation:
Departamento de Psiquiatría Biológica, Universidad Médica de Innsbruck, Anichstrasse 35, A-6020Innsbruck, Austria
Monika Edlinger
Affiliation:
Departamento de Psiquiatría Biológica, Universidad Médica de Innsbruck, Anichstrasse 35, A-6020Innsbruck, Austria
Martina Hummer
Affiliation:
Departamento de Psiquiatría Biológica, Universidad Médica de Innsbruck, Anichstrasse 35, A-6020Innsbruck, Austria
Georg Kemmler
Affiliation:
Departamento de Psiquiatría Biológica, Universidad Médica de Innsbruck, Anichstrasse 35, A-6020Innsbruck, Austria
Maria A. Rettenbacher
Affiliation:
Departamento de Psiquiatría Biológica, Universidad Médica de Innsbruck, Anichstrasse 35, A-6020Innsbruck, Austria
W. Wolfgang Fleischhacker
Affiliation:
Departamento de Psiquiatría Biológica, Universidad Médica de Innsbruck, Anichstrasse 35, A-6020Innsbruck, Austria
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Resumen

Antecedentes

Se considera cada vez más que la disfunción cognitiva es el predictor clínico más fuerte de mala evolución a largo plazo en la esquizofrenia. Se han encontrado asociaciones entre la gravedad de los déficit cognitivos y la disfunción social, la afectación de la vida independiente, las limitaciones ocupacionales y las perturbaciones en la calidad de vida (CdV).

Métodos

En este estudio transversal, se examinó las relaciones de los déficit cognitivos y el resultado del tratamiento desde el punto de vista de la CdV, las necesidades y el funcionamiento psicosocial en 60 pacientes ambulatorios con esquizofrenia que tenían una duración de la enfermedad de más de 2 años y habían recibido tratamiento con clozapina u olanzapina durante al menos 6 meses.

Resultados

El presente estudio indica que el funcionamiento cognitivo podría ser un predictor de la evolución en el funcionamiento laboral/vida independiente en los pacientes estabilizados con esquizofrenia: los déficit de memoria visual y memoria operativa se asociaban negativamente con el funcionamiento ocupacional, y los pacientes mayores vivían independientemente, en pareja estable o ambas cosas más a menudo. Las evaluaciones de los pacientes de la CdV y las necesidades de asistencia no mostraron asociaciones significativas con el funcionamiento cognitivo.

Discusión

Estos hallazgos indican que el funcionamiento cognitivo es un determinante clave del funcionamiento laboral/vida independiente para los pacientes ambulatorios estables con esquizofrenia.

Keywords

EsquizofreniaCogniciónEvoluciónNecesidadesCalidad de vidaEmpleo
Type
Artículo Original
Information
European Psychiatry (Ed. Española) , Volume 13 , Issue 2 , March 2006 , pp. 86 - 94
Copyright
Copyright © European Psychiatric Association 2006

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References

Bibliografía

[1]Addington, J, Addington, DNeurocognitive and social functioning in schizophrenia. Schizophr Bull 1999;25:173-82.CrossRefGoogle Scholar
[2]Aschenberger, S, Tucher, O, Lange, KWRegensburger Wortflussigkeits- Test. Gottingen: Hogrefe Verlag für Psychologie; 2000.Google Scholar
[3]Benton, AS, Spreen, ODer Benton Test. Handbuch: 7. Auflage; 1996.Google Scholar
[4]Brekke, JS, Levin, S, Wolkon, G, Sobel, G, Slade, BPsychosocial functioning and subjective experience in schizophrenia. Schizophr Bull 1993;19:599–608.CrossRefGoogle Scholar
[5]Brekke, JS, Kohrt, B, Green, MFNeuropsychological functioning as a moderator of the relationship between psychosocial functioning and the subjective experience of self and life in schizophrenia. Schizophr Bull 2001;27:697–708.CrossRefGoogle Scholar
[6]Browne, S, Roe, M, Lane, A, Gervin, M, Morris, M, Kinsella, A et al. Quality of life in schizophrenia: relationship to sociodemographic factors, symptomatology, and tardive dyskinesia. Acta Psychiatr Scand 1996;94:118-24.CrossRefGoogle ScholarPubMed
[7]Corrigan, PW, Reinke, RR, Landsberger, SA, Charate, A, Toombs, GAThe effects of atypical antipsychotic medications on psychosocial outcomes. Schizophr Res 2003;63:97–101.CrossRefGoogle ScholarPubMed
[8]Delis, DC, Kramer, JH, Kaplan, E, Ober, BACalifornia verbal learning and memory test (Manual). San Antonio, TX: Psychological Corporation; 1987.Google Scholar
[9]Dillon, WR, Goldstein, MMultivariate analysis. Methods and applications. New York: Wiley; 1984.Google Scholar
[10]Fleischhacker, WWPharmacological treatment of schizophrenia: a review. In: Maj, M, Sartorius, N editors. Schizophrenia. WPA Series evidence and experience in psychiatry. Chichester, NY, Weinheim, Brisbane, Singapore, Toronto: Wiley; 2002. p. 75–113.Google Scholar
[11]Green, MEWhat are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 1996;153:321-30.Google Scholar
[12]Green, MF, Kern, RS, Braff, DL, Mintz, JNeurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”? Schizophr Bull 2000;26:119-36.CrossRefGoogle ScholarPubMed
[13]Hamilton, SH, Edgell, ET, Revicki, DA, Breier, AFunctional outcomes in schizophrenia: a comparison of olanzapine and haloperidol in a European sample. Clin Psychopharmacol 2000;15:245-55.CrossRefGoogle Scholar
[14]Harvey, PD, Green, MF, Keefe, RSE, Velligan, DICognitive functioning in schizophrenia: a consensus statement on its role in the definition and evaluation of effective treatments for the illness. J Clin Psychiatry 2004;65:361-72.CrossRefGoogle ScholarPubMed
[15]Heaton, RK, Chelune, GJ, Taley, JL, Kay, GG, Curtiss, GWisconsin Card Sorting Test manual: revised and expended. Odessa, FL: Psychological Assessment Resources; 1993.Google Scholar
[16]Hofer, A, Kemmler, G, Eder, U, Edlinger, M, Hummer, M, Fleischhacker, WWQuality of life in schizophrenia: the impact of psychopathology, drug attitude and side effects. J Clin Psychiatry 2004;65:932-9.CrossRefGoogle ScholarPubMed
[17]Hofer, A, Baumgartner, S, Edlinger, M, Hummer, M, Kemmler, G, Rettenbacher, MA et al. Patient outcomes in schizophrenia I: the impact of sociodemographic variables, psychopathology, and side effects. Eur Psychiatry 2005;20 (in press).CrossRefGoogle Scholar
[18]Karow, A, Naber, DSubjective well-being and quality of life under atypical antipsychotic treatment. Psychopharmacology (Berlin) 2002;162:3–10.CrossRefGoogle ScholarPubMed
[19]Kay, SR, Fiszbein, A, Opler, LAThe Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261-76.CrossRefGoogle Scholar
[20]Kemmler, G, Holzner, B, Neudorfer, C, Meise, U, Hinterhuber, HGeneral life satisfaction and domain-specific quality of life in chronic schizophrenic patients. Qual Life Res 1997;6:265-73.CrossRefGoogle ScholarPubMed
[21]Landau, S, Everitt, BSA handbook of statistical analyses using SPSS. London: Chapman and Hall; 2004.Google Scholar
[22]Lehrl, SManual zum MWT-B. Erlangen: Verlag Dr. med. D. Straube; 1977.Google Scholar
[23]Leung, A, Chue, PSex differences in schizophrenia, a review of the literature. Acta Psychiatr Scand 2000;101:3–38.CrossRefGoogle Scholar
[24]Lindenmayer, JP, Bernstein-Hyman, R, Grochowski, SFive-factor modal of schizophrenia. J Nerv Ment Dis 1994;182:631-8.CrossRefGoogle Scholar
[25]Lindenmayer, JP, Grochowski, S, Hyman, RBFive factor model of schizophrenia: replication across samples. Schizophr Res 1995;14:229-34.CrossRefGoogle ScholarPubMed
[26]Littrell, KH, Petty, RG, Hilligoss, NM, Kirshner, CD, Johnson, CGImprovement in social cognition in patients with schizophrenia associated with treatment with olanzapine. Schizophr Res 2004;66:201-2.CrossRefGoogle ScholarPubMed
[27]McGurk, S, Moriarty, PJ, Harvey, PD, Parrella, M, White, L, Davis, KLThe longitudinal relationship of clinical symptoms, cognitive functioning, and adaptive life in geriatric schizophrenia. Schizophr Res 2000;42:47–55.CrossRefGoogle ScholarPubMed
[28]Priebe, S, Heinze, M, Jäkel, ABerliner Bedürfnisinventar (BeBI). Berlin: Abteilung fur Sozialpsychiatrie, FU; 1993.Google Scholar
[29]Rempfer, MV, Hamera, EK, Brown, CE, Cromwell, RLThe relations between cognition and the independent living skill of shopping in people with schizophrenia. Psychiatry Res 2003;117:103-12.CrossRefGoogle ScholarPubMed
[30]Sartorius, N, Fleischhacker, WW, Gjerris, U, Kern, U, Knapp, M, Leonard, BE et al. The usefulness and use of second generation antipsychotic medications—an update. Curr Opin Psychiatry 2003;16(Suppl l):1–44.Google Scholar
[31]Sharma, T, Antonova, LCognitive function in schizophrenia. Deficits, functional consequences, and future treatment. Psychiatr Clin North Am 2003;26:25–40.CrossRefGoogle ScholarPubMed
[32]Sharma, T, Hughes, C, Soni, W, Kumari, VCognitive effects of olanzapine and clozapine treatment in chronic schizophrenia. Psychopharmacology (Berlin) 2003;169:398–403.CrossRefGoogle ScholarPubMed
[33]Slade, M, Thornicroft, G, Loftus, L, Phelan, M, Wykes, TCAN: Camberwell Assessment of Need Scales. London: Gaskell; 1999.Google Scholar
[34]The WHOQOL Group. Development of the World Health Organization WHOQOL-BREF quality of life assessment. Psychol Med 1998;28:551-8.CrossRefGoogle Scholar
[35]Velligan, DI, Mahurin, RK, Diamond, PL, Hazleton, BC, Eckert, SL, Miller, ALThe functional significance of symptomatology and cognitive function in schizophrenia. Schizophr Res 1997;25:21–31.CrossRefGoogle Scholar
[36]Velligan, DI, Bow-Thomas, CC, Mahurin, RK, Miller, AL, Halgunseth, LCDo specific neurocognitive deficits predict specific domains of community function in schizophrenia? J Nerv Ment Dis 2000;188:518-24.CrossRefGoogle Scholar
[37]Weiden, P, Mackell, J In: Lecture held at the 152nd Annual Meeting of the APA, Washington, DC. 1999 May 15-20.Google Scholar
[38]Weiss, EM, Bilder, RM, Fleischhacker, WWThe effects of secondgeneration antipsychotics on cognitive functioning and psychosocial outcome in schizophrenia. Psychopharmacology (Berlin) 2002;162:11-7.CrossRefGoogle Scholar
[39]Zimmermann, P, Fimm, BTestbatterie zur Aufmerksamkeitsprufung (TAP), Version 1.7. Herzogemath: Vera Fimm/Psychologische Testsysteme. 2002.Google Scholar