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Enfermedad de Huntington: una revisión de las publicaciones sobre la prevalencia y el tratamiento de los fenomenós neuropsiquiátricos

Published online by Cambridge University Press:  12 May 2020

P. Naarding
Affiliation:
Centro Médico Universitario de Nimega, Departamento de Psiquiatría, P. O. Box 9101, 6500HB Nimega, Paises Bajo
H.P.H. Kremer
Affiliation:
Centro Médico Universitario de Nimega, Departamento de Neurología, Nimega, Países
F.G. Zitman
Affiliation:
Centro Médico Universitario de Leiden, Leiden, Países Bajos
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Resumen

Se realizó una revisión de las publicaciones sobre la enfermedad de Huntington, incluidas las manifestaciones neurológicas clínicas, los avances recientes en los aspectos fisiopatológicos y los mecanismos genéticos y los trastornos psicopatológicos. Se puede concluir que la investigación sobre esto último es escasa, aunque la materia es pertinente a causa de la coincidencia de fenómenos psiquiátricos, neurológicos y genéticos, lo que puede llevar a conceptos nuevos en la comprensión de la función cerebral. Hasta ahora, los intentos de proporcionar una descriptión amplia y pragmática de los trastornos psicopatológicos de la enfermedad de Huntington han sido decepcionantes, debido probablemente a las limitaciones del sistema de clasificación del DSM en este trastorno. La investigación futura debe centrarse no sólo en este sistema de clasificación, sino también en el funcionamiento neuropsicológico, a causa de la naturaleza degenerativa de la enfermedad. Se deben realizar estudios sistematicos y controlados sobre el tratamiento de las anomalías psiquiátricas en la enfermedad de Huntington antes de que se pueda extraer alguna conclusión.

Type
Revisión
Copyright
Copyright © European Psychiatric Association 2002

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References

Bibliografía

Benson, DF.Progressive frontal dysfunction. Dementia 1993;4:149-53.Google ScholarPubMed
Bhandary, ANMasand, PS.Buspirone in the management of disruptive behaviors due to Huntington’s disease and other neurological disorders. Psychosomatics 1997;38:389-91.CrossRefGoogle ScholarPubMed
Burns, AFolstein, SBrandt, JFolstein, M.Clinical assessment of irritability, aggression, and apathy in Huntington and Alzheimer disease. J Nerv Ment Dis 1990;178:20-6.CrossRefGoogle ScholarPubMed
Byrne, AMartin, WHnatko, G.Beneficial effects of buspirone therapy in Huntington’s disease. Am J Psychiatry 1994;151:1097.Google ScholarPubMed
Caine, EDHunt, RDWeingartner, HEbert, MH.Huntington’s dementia. Clinical and neuropsychological features. Arch Gen Psychiatry 1978;35:377-84.CrossRefGoogle ScholarPubMed
Caine, EDShoulson, I.Psychiatric syndromes in Huntington’s disease. Am J Psychiatry 1983;140:728-33.Google ScholarPubMed
Como, PGRubin, AJO’Brien, CFLawler, KHickey, CRubin, AE, et al.A controlled trial of fluoxetine in nondepressed patients with Huntington’s disease. Mov Disord 1997;12:397-401.CrossRefGoogle ScholarPubMed
Cummings, JLMega, MGray, KRosenberg-Thompson, SCarusi, DAGornhein, J.The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994;44:2308-14.CrossRefGoogle ScholarPubMed
Cummings, JL.Frontal-subcortical circuits and human behaviour. Arch Neurol 1993;50:873-80.CrossRefGoogle Scholar
Di Malo, LSquitieri, FNapolitano, GCampanella, GTrofatter, JAConneally, PM.Onset symptoms in 510 patients with Huntington’s disease. J Med Genet 1993;30:289-92.CrossRefGoogle Scholar
Findling, RL.Treatment of aggression in juvenile-onset Hun tington’s disease with buspirone [letter]. Psychosomatics 1993;34:460-1.CrossRefGoogle Scholar
Folstein, SAbbott, MHChase, GAJensen, BAFolstein, MR.The association of affective disorder with Huntington’s disease in a case series and in familias. Psychol Med 1983;13:537-42.CrossRefGoogle Scholar
Ford, MF.Treatment of depression in Huntington’s disease with monoamine oxidase inhibitors. BrJ Psychiatry 1986;149:654-6.CrossRefGoogle ScholarPubMed
Giel, RNienhuis, FJ.SCAN version 2.1, Dutch version in co-operation with the WHO, Genova, Switzerland. Lisse: Swets & Zeitlinger; 1999.Google Scholar
Group, THd, CRA novel gene containing a trinucleotide repeat that is expended and flnstable on Huntington’s disease chromosomes. Cell 1993;72:971-83.Google Scholar
Huntington, G.On chorea. Med Surg Rep 1872;26:317-21.Google Scholar
Lewis, CFDeQuardo, JRTandon, R.ECT in genetically confirmed Huntington’s disease. J Neuropsychiatry Clin Neurosci 1996;8:209-10.Google ScholarPubMed
Madhusoodanan, SBrenner, R.Use of risperidone in psychosis associated with Huntington’s disease [letter]. Am J Geriatr Psychiatry 1998;6:347-9.Google Scholar
Mendez, MF.Huntington’s disease: update and review of neuropsychiatric aspects. Int J Psychiatry Med 1994;24:189-208.CrossRefGoogle ScholarPubMed
Patel, SVTariot, PNAsnis, J.L-Deprenyl augmentation of fluoxetine in a patient with Huntington’s disease. Ann Clin Psychiatry 1996;8:23-6.CrossRefGoogle Scholar
Pflanz, SBesson, JWSEbmeier, KPSimpson, S.The clinical manifestations of mental disorder in Huntington’s disease: a retrospective case record study of disease progression. Acta Psychiatr Stand 1991;83:53-60.CrossRefGoogle Scholar
Ranen, NG, LipseyJR, Treisman, GRoss, CA.Sertraline in the treatment of severe aggressiveness in Huntington’s disease. J Neuropsychiatry Clin Neurosci 1996;8:338-40.Google ScholarPubMed
Ranen, NGPeyser, CEFolstein, SE.ECT as a treatment for depression in Huntington’s disease. J Neuropsychiatry Clin Neurosci 1994;6:154-9.Google ScholarPubMed
Sajatovic, MVerbanac, P, Ramirez' LF, Meltzer, HY.Clozapine treatment of psychiatric symptoms resistant to neuroleptic treatment in patients with Huntington’s chorea. Neurology 1991;41:156.CrossRefGoogle ScholarPubMed
Schoenfeld, MMyers, RHCupples, LA.Increased rafe of suicide among patients with Huntington’s disease. J Neurol Neurosurg Psychiatry 1984;47:1283-7.CrossRefGoogle Scholar
Shiwach, R.Psychopathology in Huntington’s disease patients. Acta Psychiatr Stand 1994;90:241-6.CrossRefGoogle ScholarPubMed
Shoulson, I.Huntington’s disease: cognitive and psychiatric features. Neuropsychiatry Neuropsychol Behav Neurol 1990;3:15-22.Google Scholar
Shoulson, I.Huntington’s disease: functional capacities in patients treated with neuroleptic and antidepressant drugs. Neurology 1981;31:1333-5.CrossRefGoogle ScholarPubMed
Stewart, JTMounts, MLClark, RL.Aggressive behavior in Huntington’s disease: treatment with propranolol. J Clin Psychiatry 1987;48:106-8.Google ScholarPubMed
Stewart, JT.Huntington’s disease and propranolol [letter]. Am J Psychiatry 1993;150:166-7.Google Scholar
Weigell-Weber, MSchmid, WSpiegel, R.Psychiatric symptoms and CAG expansion in Huntington’s disease. Am J Med Genet 1996;67:53-7.Google ScholarPubMed
Whittier, JHaydu, GCrawford, MA.Effect of imipramine on depression and hyperkinesia in Huntington’s disease. Am J Psychiatry 1962;118:79.CrossRefGoogle Scholar