Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-05T14:01:18.227Z Has data issue: false hasContentIssue false

El polimorfismo Taql A del gen del receptor D2 de la dopamina no se asocia con la búsqueda de novedad, la evitación del daño y la dependencia de la recompensa en los sujetos sanos

Published online by Cambridge University Press:  12 May 2020

B. de Brettes
Affiliation:
Servicio de Farmacología, Hospital Pitié-Salpêtrière, 47, Boulevard de l’Hôpital, 75013, Paris
I. Berlin
Affiliation:
Servicio de Farmacología, Hospital Pitié-Salpêtrière, 47, Boulevard de l’Hôpital, 75013, Paris
C. Laurent
Affiliation:
Laboratorio de Genética Molecular de la Neurotransmisión y de Procesos Neurodegenerativos C 9923 CNRS, Hospital Pitié-Salpêtrière
J. P. Lépine
Affiliation:
Servicio de Psiquiatría, Hospital Fernand Widal, París, Francia
J. Mallet
Affiliation:
Laboratorio de Genética Molecular de la Neurotransmisión y de Procesos Neurodegenerativos C 9923 CNRS, Hospital Pitié-Salpêtrière
A. J. Puech
Affiliation:
Servicio de Farmacología, Hospital Pitié-Salpêtrière, 47, Boulevard de l’Hôpital, 75013, Paris
Get access

Resumen

Se ha encontrado que el alelo A1 del polimorfismo de longitud de fragmentos de restricción (RFLP) Taql A del gen del receptor D2 de dopamina está asociado con el abuso de sustancias y el alcoholismo. El rasgo de personalidad búsqueda de la novedad (BN) se asocia también con el abuso y la dependencia de sustancias. Sobre la base de la implicación de mecanismos dopaminérgicos en el abuso de sustancias, formamos la hipótesis de que la presencia del alelo A1 del gen del receptor D2 de dopamina puede representar una predisposición genérica para el rasgo de personalidad BN. Por tanto, investigamos si el alelo A1 del RFLP Tagí A del gen del receptor D2 de dopamina se asocia con la dimensión de BN del Cuestionario Tridimensional de la Personalidad (TPQ) en sujetos caucasianos sanos sin historia de abuso o dependencia de alcohol o sustancias. Determinamos el genotipo de 204 sujetos de 18 a 30 años edad. No hubo asociación entre ninguno de los alelos de los genes del receptor D2 y ninguna de las puntuaciones del TPQ (BN, Evitación del daño, Dependencia de la recompensa). Concluimos que el alelo A1 del RFLP Taql A del receptor D2 de dopamina no se asocia con el rasgo de personalidad BN en los sujetos caucasianos sanos.

Type
Comunicación Breve
Copyright
Copyright © European Psychiatric Association 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

de BrettesB, BerlínI, LaurentC, LépineJP, MalletJ, PuechAJ. El polimorfismo Taql A del gen del receptor D2 de la dopamina no se asocia con la búsqueda de novedad, la evitación del daño y la dependencia de la recompensa en los sujetos sanos. Eur Psychiatry1998; 13: 427–30.

References

Bibliografía

Altman, J, Everitt, BJ, Glautier, S, Markou, A, Nutt, D, Oretti, R, et al.The biological, social and clinical bases of drug addiction: commentary and debate. Psychopharmacology 1996; 125: 285345.CrossRefGoogle ScholarPubMed
Amadéo, S, Abbar, M, Fourcade, ML, Waksman, G, Leroux, MG, Madec, A, et al.D2 dopamine receptor gene and alcoholism. J Psychiat Res 1993; 2: 173–9.CrossRefGoogle Scholar
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. DSM-IV. Washington DC; 1994.Google Scholar
Balldin, JI, Berggrén, UC, Lindstedt, G.Neuroendocrine evidence for reduced dopamine receptor sensitivity in alcoholism. Alcoholism Clin Exp Res 1992; 16: 71–4.CrossRefGoogle ScholarPubMed
Benjamin, J, Li, L, Patterson, C, Greenberg, BD, Murphy, DL, Hamer, DH.Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nature Genet 1996; 12: 81–4.CrossRefGoogle ScholarPubMed
Blum, K, Noble, EP, Sheridan, PJ, Finley, O, Montgomery, A, Ritchie, T, et al.Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 1990; 263: 2055–60.CrossRefGoogle ScholarPubMed
Cloninger, CR.A systematic method for clinical description and classification of personality variants. Arch Gen Psychiatry 1987; 44: 573–88.CrossRefGoogle ScholarPubMed
Cloninger, CR, Przybec, TR, Svrakic, DM.The Tridimensional Personality Questionnaire? US normative-data. Psychological Reports 1991; 69: 1047–57.CrossRefGoogle Scholar
Compton, PA, Anglin, MD, Khalsa-Denison, E, Paredes, A.The D2 dopamine receptor gene, adiction, and personality? clinical correlates in cocaine abusers. Biol Psychiatry 1996; 39: 302–4.CrossRefGoogle Scholar
Ebstein, RB, Novick, O, Umansky, R, Priel, B, Osher, Y, Baline, D, et al.Dopamine D4 receptor (D4DR) polymorphism associated with the human personality trait of Novelty seeking. Nature Genet 1996; 12: 7880.CrossRefGoogle ScholarPubMed
Farde, L, Gustavsson, JP, Jönsson, E.D2 dopamine receptors and personality traits. Nature 1997; 385: 590.CrossRefGoogle ScholarPubMed
Farré, M, Lamas, X, Cami, J.Sensation seeking amongst healthy volunteers participating in phase I clinical trials. Brit J Clin Pharmacol 1995; 39: 405–9.CrossRefGoogle ScholarPubMed
Gelernter, J, Goldman, D, Risch, N.The A1 allele at the D2 dopamine receptor gene and alcoholism. JAMA 1993; 269: 1673–7.CrossRefGoogle ScholarPubMed
Grandy, DK, Zhang, Y, Civelli, O.PCR detection of the TaqA RFLP at the DRD2 locus. Hum Mol Genet 1993; 2: 2197.CrossRefGoogle ScholarPubMed
Jönsson, EG, Nöthen, MM, Gustavsson, JP, Neidt, H, Berné, S, Tylec, A, et al.Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphism. Am J Psychiatry 1997; 154: 697–9.Google Scholar
Lépine, J, Pelissolo, A, Téodorescu, R, Téhérani, M.Evaluation des propriétés psychométriques de la version franfaise du questionnaire tridimensionnel de la personnalité (TPO). L’Encéphale 1994; XX: 747–53.Google Scholar
Malhotra, AK, Virkkunen, M, Rooney, W, Eggert, M, Linnoila, M, Goldman, D.The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and Novelty Seeking. Mol Psychiatry 1996; 1: 388–91.Google ScholarPubMed
Noble, EP, Blum, K, Ritchie, T, Montgomery, A, Sheridan, PJ.Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 1991; 48: 648–54.CrossRefGoogle ScholarPubMed
O’Hara, BF, Smith, SS, Bird, G, Persico, AM, Suarez, BK, Cutting, GR, et al.Dopamine D2 receptor RFLPs, haplotypes and their association with substance use in black and Caucasian research volunteers. Hum Hered 1993; 43: 209–18.Google ScholarPubMed
Ono, Y, Manki, H, Yoshimura, K, Muramatsu, T, Mizushima, H, Higuchi, S, et al.Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects. Am J Med Genet 1997; 74: 501–3.3.0.CO;2-Q>CrossRefGoogle ScholarPubMed
Smith, SS, O’Hara, BF, Persico, AM, Gorelick, DA, Newlin, DB, Vlahov, D, et al.Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in poly-substance abusers. Arch Gen Psychiatry 1992; 49: 723–7.CrossRefGoogle Scholar
Stallings, MC, Hewitt, JK, Cloninger, CR, Heath, AC, Eaves, LJ.Genetic and environmental structure of the Tridimensional Personality Questionnaire: three our four temperament dimensions? J Personality Soc Psychol 1996; 70: 127–40.CrossRefGoogle ScholarPubMed
Vandenbergh, DJ, Zonderman, AB, Wang, J, Uhl, GR, Costa, PT.No association between Novelty Seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Ageing participants. Mol Psychiatry 1997; 2: 417–9.CrossRefGoogle Scholar