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Eficacia de zolpidem en el insomnio

Published online by Cambridge University Press:  12 May 2020

R. G. Priest ,
M. G. Terzano ,
L. Parrino  and
P. Boyer
R. G. Priest
Affiliation:
Escuela Médica del Hospital de Santa María, Londres, Reino Unido
M. G. Terzano
Affiliation:
Centro de Trastornos, Departamento de Neurología, Universidad de Parma, Italia
L. Parrino
Affiliation:
Centro de Trastornos, Departamento de Neurología, Universidad de Parma, Italia
P. Boyer
Affiliation:
Clínica INSERM de las enfermedades mentales y del encéfalo, París, Francia
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Resumen

Se revisó la eficacia de zolpidem, un agente hipnótico no benzodiacepínico con una semivida de eliminación corta, analizando más de 50 ensayos clínicos internacionales publicados desde 1986. Se ha evaluado la actividad hipnótica de zolpidem en diferentes poblaciones de pacientes, incluidos voluntarios sanos, pacientes ambulatorios de medicina general y pacientes psiquiátricos ambulatorios u hospitalizados con diversos trastornos del sueño, tanto transitorios como crónicos. Los métodos de evaluación utilizados han incluido mediciones objetivas y subjetivas de la eficacia hipnótica para tratamiento de duraciones diferentes, con resultados que confirman que 10 mg es superior a placebo. Zolpidem se mostró superior, en la mayor parte de ensayos, en los parámetros de sueño, como el tiempo total de sueño, la latencia de comienzo del sueño y los despertares nocturnos, pero normalmente, el sueño REM total y la latencia de REM no experimentaron modificaciones. Zolpidem conservó la fisiología del sueño normal, como lo demuestra la preservación de las fases de ondas lentas y la ausencia de efectos o los efectos mínimos sobre la arquitectura del sueño después de una interrupción brusca. En consecuencia, 10 mg es la dosis recomendada para el tratamiento a corto plazo del insomnio en personas no ancianas; en pacientes ancianos 5 mg induce de manera efectiva el sueño, con un perfil de seguridad óptimo.

Keywords

zolpidemhipnóticosimidazopiridinaspolisomnografíasueño
Type
Revisión
Information
European Psychiatry (Ed. Española) , Volume 3 , Issue 2 , April 1996 , pp. 85 - 96
Copyright
Copyright © European Psychiatric Association 1996

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References

Bibliografia

Allain, H, Le Coz, F, Morel, Get al. A double-blind study of the effect of zolpidem in chronic insomniac outpatients in substitution of triazolam. Clin Neuropharm 1992; 15(suppll B): 77B.Google Scholar
Benoit, O, Aguirre, A, Bouard, Get al. Effect of zolpidem on all-night spectral analysis of sleep. In: Book of abstracts, WFSRS, Cannes, France, 21-25 Sept. 1991. Sleep Res 1991; 20A: 118.Google Scholar
Besset, A, Tafti, M, Billiard, M. Effects of zolpidem on sleep architecture and daytime psychomotor skills in poor sleepes. In: Abstract books, 1Oth Congress of the European Sleep Research Society, Strasbourg, 20-25 May 1990, 138.Google Scholar
Biondi, F. Risultati finali (1152 pazienti) dello studio policentrico italiano zolpidem-insomnia. Poster presentation al XXVIIo Congresso delo Società Italiana di neurologia, Sorrento, 21-26 Octobre 1991.Google Scholar
Blois, R, Gaillard, JM. The effects of zolpidem on characteristics of normal human sleep. In: Sauvanet, JP, Langer, SZ, Morselli, PL eds. Imidazopyridines in Sleep Disorders: a Novel Experimental and Therapeutic Approach. (LERS Monograph series; vol 6). New York: Raven Press, 1988; 375–6.Google Scholar
Calanca, A, Dick, P, Efficacité du nouvel hypnotique zolpidem (STIL-NOX) en pratique ambulatoire (étude coopérative de praticiens de Genève, Lausanne et Tessin). Rev Méd Suisse Romande 1991; 111: 85–8.Google Scholar
Chaumet-Riffaud, AE, Guerault, E, Demontrond, V. Clinical safety of three therapy with zolpidem after Progressive shift from a benzodiazepine hypnotic: results of a French post-marketing survey. J Sleep Res 1992; 1 (suppl 1): 40.Google Scholar
Ciapparelli, A, Colombo, C, Cuccato, G et al, Shift to zolpidem, a new imidazopyridine hypnotic, in insomniac patients previously taking benzodiazepine hypnotics. Minerva Psichiatr Psicol 1991; 32: 3–12.Google Scholar
Declerck, A, Ruwe, F, O’Hanlon, J, Wauquier, A. Effects of zolpidem and flunitrazepam on women subjectively complaining of insomnia. Psychopharmacology 1992a; 106: 497–501.CrossRefGoogle Scholar
Declerck, A, Smits, M, Durlinger, Eet al. Zolpidem in the treatment of insomnia after cesation of the use of benzodiazepines. In: Abstracts of the llth European Congress of the ERD, Finland 5-10 July 1992. J Sleep Res 1992b; 1 (suppl 1): 53.Google Scholar
De Roeck, JMJ, Cluydts, RJG. étude polysomnographique d’un traitrement à court terme par le zolpidem dans l’insomnie psychophysiologique chronique. In: Abstract book of the Symposium STIL-NOX lst Imidazopyridine. 10th Congress of the European Sleep Research Society, Strasbourg, 20-25 May 1990. Adis 1991; 133–42.Google Scholar
Durlinger, E, Verbeek, I, Beechere, L et al. Effects of zolpidem on the nocturnal sleep of chronic insomnia patients with severe sleep onset problems. In: Abstracts of the 11th European Congress of the ESRS, Finland 5-10 July 1992. J Sleep Res 1992; 1 (suppl 1): 65.Google Scholar
Emeriau, J, Descamps, A, Dechelotte, Pet al. Zolpidem and flunitrazepam: a multicenter trial in elderly hospitalized patients. In: Sauvanet, JP, Langer, SZ, Morselli, PL, eds. Imidazopyridines in Sleep Disorders: a Novel Experimental and Therapeutic Approach. (LERS Monograph series; vol. 6). New York: Raven Press, 1988; 317–26.Google Scholar
Fairweather, D, Kerr, J, Hindmarch, I. The effects of acute and repeated doses of zolpidem on subjective sleep, psychomotor performance and cognitive function in elderly volunteers. Eur J Clin Pharmacol 1992; 43 (6): 597–601.Google ScholarPubMed
Ferrand, I, Borderies, P, Peigne, P. Use of zolpidem 10 mg in psyichiatric inpatients. In: Abstraeis of the 5th World Congress of Biological Psychiatry, Florence, Italy, 10-14 June 1991. Biol Psychiatry 1991; 29 (11S), 521S.Google Scholar
Ferillo, F, Balestra, V, De Carli, Fet al. Effects of the administration of zolpidem and triazolam on the dynamics of EEG slow waves during sleep. In: Abstracts of the llth European Congress of the ESRS, Finland 5-10 July 1992. J Sleep Res 1992; 1 (suppl 1): 72.Google Scholar
Frattola, L, Maggioni, M, Cesana, B, Priore, P, Double blind comparison of zolpidem 20 mg versus flunitrazepam 2 mg in insomniac in-patients. Drugs Exp Clin Res 1990; 16: 371–6.Google ScholarPubMed
Godderis, J, Gluydts, R. Substitution from a benzodiazepine to zolpidem in elderly insomniacs: preliminary data. In: Abstracts of the 11th European Congress of the ESRS, Finland 5-10 July 1992. J Sleep Res 1992; 1 (suppl 1): 83.Google Scholar
Hermanh, WM, Kubicki, S, Wober, W. Zolpidem: a four-week pilot polysomnographic study in patients with chronic sleep disturbances. In: Sauvanet, JP, Langer, SZ, Morselli, PL, eds. Imidazopyridines in Sleep Disorders: a Novel Experimental and Therapeutic Approach. (LERS Monograph series; vol 6). New York: Raven Press, 1988; 261–78.Google Scholar
Jolie, A, Scheldewaert, R, Vermeire, Set al. Efficacy and toleranee study of zolpidem 10 mg in an open general practice study. In: Book of Abstracts of World Federation of Sleep Research Societies, Cannes, France, 21-25 Sept. 1991a; 20A: 330.Google Scholar
Jolie, A, Scheldewaert, R, Franck, G, Poirrier, R. Effects of zolpidem, after one month of treatment, on nocturnal polysomnography and multiple sleep lateney test in psychophysiologic insomnia. In: Book of abstracts, WFSRS, Cannes, France, 21-25 Sept. 1991. Sleep Res 1991b; 20A 330.Google Scholar
Kanno, O, Watanabe, H, Iyo, R et al. Effects of zolpidem and triazolam on all-night sleep EEG in normal volunteers. Assessing the sleep stages by thirds of the night. Clin Neuropharmacol 1992; 15 suppl 1,543 B.CrossRefGoogle Scholar
Kryger, MH, Steljes, D, Pouliot, Z et al, Subjective versus objective evaluation of hypnotic efficacy: experience with zolpidem. Sleep 1991; 14: 339–407.Google ScholarPubMed
Kudo, Y, Kawakita, Y, Saito, M et al. A dose finding study of zolpidem in chronic insomnia patients in multi-center cooperation. Clin Neuropharmacol 1992; 5 (suppl IB): 76B.CrossRefGoogle Scholar
Kummer, J, Zander, K. Polysomnographic profile of longterm efficacy of zolpidem after withdrawal in elderly psychiatric inpatients with severe insomnia. In: Abstracts of the 5th World Congress of Biological Psychiatry, Florence, Italy, 10-14 June 1991. Br J Psychiatry 1991; 29 (11S): 517S.Google Scholar
Kurtz, D, Fillius, B, Boningen, C et al. Effect of zolpidem on the sleep of healthy elderly subjeets: polysomnographic recording assessments and pharmaco-kinetics. In: Sauvanet, JP, Langer, SZ, Morselli, PL, eds. Imidazopyridines in Sleep Disorders: a Novel Experimental and Therapeutic Approach. Sauvanet JP, Langer SZ, Morselli PL eds. (LERS Monograph series; vol 6). New York: Raven Press, 1988; 382.Google Scholar
Kurtz, D, Baas, V, Rumbach, I. Effects de Fadministration répétée de zolpidem 10 mg sur le sommeil et la vigilance diurne chez des mauvais dormeurs. In: Abstract book of the Symposium STILNOX 1st Imidazopyridine. 10th Congress of the Europan Sleep Research Society, Strasbourg, 20-25 May 1990. Adis 1991; 143–51.Google Scholar
Licciardello, L, Licini, P. Safety and efficacy of zolpidem therapy in sleep disorders: a multicenter trial in hospitalized patients. Curr Ther Res Clin Exp 1992;52 (5): 652–8.CrossRefGoogle Scholar
Lorizio, A, Terzano, M, Parrino, L. Controlled study of the efficacy and safety of two oral doses of zolpidem (10 and 20 mg). In: Sauvanet, JP, Lager, SZ, Morselli, PL, eds. Imidazopyridines in Sleep Disorders: a Novel Experimental and Therapeutic Approach. (LERS Monograph series; vol 6). New York: Raven Press, 1988; 385.Google Scholar
Lund, R, Rüther E, Wober, Hippius, H. Effects of zolpidem (10 and 20 mg), lormetazepam, triazolam and placebo on night sleep and residual effects during the day. In: Sauvanet, JP, Lager, SZ, Morselli, PL, eds. Imidazopyridines in Sleep Disorders: a Novel Experimental and Therapeutic Approach. (LERS Monograph series; vol 6). New York: Raven Press, 1988; 193–203.Google Scholar
Maarek, L, Cramer, P, Atali, P et al, The safety and efficacy of zolpidem in insomniac patients: a long-term open study in general practice. J Int Med Res 1992; 20: 162–170.CrossRefGoogle ScholarPubMed
Merlotti, L, Roehrs, T, Koschorek, G et al. The dose effects of zolpidem on the sleep of healthy normals. J Clin Psychopharmacol 1989; 9 (1): 9–14.CrossRefGoogle ScholarPubMed
Monti, J, Monti, D, Attali, P. Comparative hypnotic and witlidrawal effects of zolpidem, triazolam and placebo in insomniac patients. In: Abstracts of the llth European Congress of the ESRS, Finland 5-10 July 1992. J Sleep Res 1992; 1 (suppl 1): 153.Google Scholar
Morgan, PJ, Chapados, R, Chung, FFT et al. Efficacy of zolpidem in patients with transient insomnia on the night before elective surgery. Sleep Res 1991; 20: 84.Google Scholar
Nicholson, A, Pascoe, P, Hypnotic activity of an imidazopyridine (zolpidem). Br J Pharmacol 1986; 21: 205–11.CrossRefGoogle Scholar
Ochs, R, Cutler, N, Dockhom, R et al. An evaluation of the effects of zolpidem in patients with short-term insomnia. In: Abstracts of the 11th European Congress of European Sleep Research Society on Sleep Research, Helsinky, Finland, 5-10 July 1992. J Sleep Res 1992; (suppl 1): 164.Google Scholar
Oswald, I, Adam, K. A new look at short-acting hypnotics. In: Sauvanet, JP, Langer, SZ, Morselli, PL, eds. Imidazopyridines in Sleep Disorders: a Novel Experimental and Therapeutic Approach. (LERS Monograph series; vol 6). New York: Raven Press, 1988; 253–9.Google Scholar
Paty, J, Aanastassiou, E, Besset, A et al. Efficacy and toleranee of a shift from benzodiazepine hypnotic drugs to zolpidem. An open study coordinated by on general practitioners. Psychol Med 1991; 3 (13): 1521–25.Google Scholar
Quera-Salva, T, Borderies, P, Moreau, J, Cugy, D. The efficacy of zolpidem during and after a progressive shift from benzodiazepine hypnotics in elderly chronic insomniac patients. J Sleep Res 1992; 1 (suppl 1): 187.Google Scholar
Roger, M, Dallot, JY, Salmon, O et al. Hypnotic effects of zolpidem in geriatric patients: a dose-finding study. In: Sauvanet, JP, Langer, SZ, Morselli, PL, eds. lmidazopyridines in Sleep Disorders: a Novel Experimental and Therapeutic Approach. (LERS Monograph series; vol 6). New York: Raven Press, 1988; 279–87.Google Scholar
Roger, M, Attali, P, Coquelin, J. Multicenter, double-blind, controlled comparison of zolpidem and triazolam in elderly patients with insomnia. Clin Ther 1993; 15 (1): 127–35.Google ScholarPubMed
Sauvanet, JP, Maarek, L, Roger, M et al. Open long-term trials with zolpidem in insomnia. In: Sauvanet, JP, Langer, SZ, Morselli, PL, eds. Imidazopyridines in Sleep Disorders: a Novel Experimental and Therapeutic Approach. (LERS Monograph series; vol 6). New York: Raven Press, 1988; 339–49.Google Scholar
Scharf, MB, Mendels, J, Weiss, B et al. Safety and efficacy of long-term zolpidem treatment in insomniacs. Sleep Res 1990; 19: 87.Google Scholar
Scharf, MB, Mayleben, DW, Kaffeman, M et al, Dose response effects of zolpidem in normal geriatric subjeets. J Clin Psychiatry 1991; 52: 77–83.Google Scholar
Scharf, M, Schweitzer, P, Fleming, J et al. Comparison of residual effects and efficacy of zolpidem, flurazepam and placebo in patients with chronic insomni. In: Abstract of the 18th Collegium Internationale Neuro-Psychopharmacologicum Congress, Nice, France, 28 June - 2 July 1992.Google Scholar
Schlich, D, L’Hertier, C, Coquelin, J, Attali, P. Long-term treatment of insomnia with zolpidem: a multicentre general practitioner study of 107 patients. J Int Med Res 1991; 19 (3): 271–9.CrossRefGoogle ScholarPubMed
Shaw, S, Curson, H, Coquelin, J, A double-blind, comparative study of zolpidem and placebo in the treatment of insomnia in elderly psychiatric in-patients. J Int Med Res 1992; 20: 150–61.CrossRefGoogle ScholarPubMed
Terzano, M, Parrino, L, Fioriti, G et al. The cyclic alternating pattern rate: asleep variable sensitive to environmental modifications. A controlled study utilizing white noise and zolpidem. In: Imidazopyridines in Sleep Disorders: a Novel Experimental and Therapeutic Approach. Sauvanet, JP, Langer, SZ, Morselli, PL, eds. (LERS Monograph series; vol 6). New York: Raven Press, 1988; 219–30.Google Scholar
Terzano, M, Parrino, L, Evaluation of EEG Cyclic alternating pattern during sleep in insomniacs and Controls under placebo and acute treatment with zolpidem. Sleep 1992; 15: 64–70.CrossRefGoogle ScholarPubMed
Verbecek, I, Durlinger, E, Beecher, L, Declerck, A. Long-term efficacy of zolpidem in the treatment of insomnia. In: abstracts of the 11th European Congress of the ESRS, Finland 5-10 July 1992: J Sleep Res 1992; (suppl 1): 242.Google Scholar
Vogel, G, Thurmond, A, Macintosch, M, Clifton, T. The effects of zolpidem on transient insomnia. Sleep Res 1988; 17: 67.Google Scholar
Walsh, JK, Schweitzer, PK, Sugerman, JL, Mushlbach, MJ, Transient insomnia associated with a 3-hour phase advance of sleep time and treatment with zolpidem. J Clin Psychopharmacol 1990; 10: 184–9.CrossRefGoogle ScholarPubMed
Walters, EG, Fairweather, D, Belgrave, GP et al. The effects of zolpidem (5 mg and 10 mg) in elderly subjects following acute and repeated administration. J Sleep Res 1992; 1 (suppl 1): 249.Google Scholar
Wheatley, D. Zolpidem and placebo: a study in general practice in patients suffering from insomnia. In: Sauvanet, JP, Langer, SZ, Morselli, PL, eds. Imidazopyridines in Sleep Disorders: a Novel Experimental and Therapeutic Approach. (LERS Monograph series; vol 6). New York: Raven Press, 1988; 305–16.Google Scholar
World Psychiatric Association, Task Force on sedative hypnotics. Eur Psychiatry 1993; 8: 45–9.Google Scholar