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Efectos de los tratamientos con antipsicóticos atípicos y típicos en la función sexual en los pacientes con esquizofrenia: resultados al año del Estudio Intercontinental de Evolución de la Salud de Pacientes Ambulatorios con Esquizofrenia (IC-SOHO)

Published online by Cambridge University Press:  12 May 2020

Martin Dossenbach ,
Yulia Dyachkova ,
Sebnem Pirildar ,
Martin Anders ,
Afaf Khalil ,
Aleksander Araszkiewicz ,
Tamara Shakhnovich ,
Aly Akram ,
Jan Pecenak  and
Margaret McBride
...Show all authors
Martin Dossenbach
Affiliation:
Eli Lilly and Company, Ges.m.b.H, Kölblgasse 8-10, 1030 Viena, Austria
Yulia Dyachkova
Affiliation:
Eli Lilly and Company, Ges.m.b.H, Kölblgasse 8-10, 1030 Viena, Austria
Sebnem Pirildar
Affiliation:
Universidad Ege, Facultad de Medicina, Departamento de Psiquiatría, Izmir, Turquía
Martin Anders
Affiliation:
Departamento de Psiquiatría, Primera Facultad de Medicina, Universidad Carlos, Ke Karlovu 11, 120 00 Praga 2, República Checa
Afaf Khalil
Affiliation:
Hospital Universitario Ein Shames, Departamento de Psiquiatría, Heliópolis, Cairo, Egipto
Aleksander Araszkiewicz
Affiliation:
Departamento de Psiquiatría, Facultad de Medicina de la Universidad de Bydgoszcz, Polonia
Tamara Shakhnovich
Affiliation:
Hospital Psiquiátrico N4, 3 Poteshnaya Str., 123298, Moscú, Rusia
Aly Akram
Affiliation:
Hospital Suliman Faqueeh, Jeddah, Arabia Saudí
Jan Pecenak
Affiliation:
Departamento de Psiquiatría, Facultad de Medicina, Universidad Comenius, Hospital Universitario de Bratislava, Mickiewiczova 13, 81369Bratislava, Eslovaquia
Margaret McBride
Affiliation:
Eli Lilly and Company, Sydney, Australia
Tamas Treuer
Affiliation:
Eli Lilly and Company, Ges.m.b.H, Kölblgasse 8-10, 1030 Viena, Austria
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Resumen

Propósito.

La disfunción sexual en los pacientes con esquizofrenia puede reducir la calidad de vida y el cumplimiento del tratamiento. Este informe comparará los efectos de antipsicóticos atípicos y típicos seleccionados sobre la función sexual en una gran población internacional de pacientes ambulatorios con esquizofrenia que recibieron tratamiento durante más de un año.

Sujetos y métodos.

Se clasificó a pacientes ambulatorios con esquizofrenia que iniciaron tratamiento antipsicótico o lo cambiaron y se incorporaron a este estudio prospectivo observacional de 3 años según la monoterapia prescrita en la línea de base: olanzapina (n = 2.638), risperidona (n = 860), quetiapina (n = 142) o haloperidol (n = 188).

Resultados.

Basado en la percepción del paciente, la probabilidad de experimentar disfunción sexual durante 1 año de terapia era significativamente más baja para los pacientes tratados con olanzapina y quetiapina cuando se comparaba con pacientes que recibían risperidona o haloperidol (todas las P ≤ 0,001). Las mujeres con olanzapina (14%) o quetiapina (8%) experimentaban una tasa inferior de irregularidades menstruales, comparado con las mujeres con risperidona (23%) o haloperidol (29%). Se puso de manifiesto una discordancia significativa entre los informes de los pacientes y la percepción del psiquiatra de la disfunción sexual, subestimando los psiquiatras la disfunción sexual (P ≤ 0,001).

Conclusiós.

Estos hallazgos indican que existen diferencias clínicamente relevantes en los perfiles de efectos secundarios sexuales de estos antipsicóticos seleccionados. Se debe considerar estos factores al seleccionar el tratamiento más apropiado para los pacientes ambulatorios con esquizofrenia.

Keywords

EsquizofreniaDisfunción sexualHiperprolactinemiaAgentes antipsicóticos
Type
Original
Information
European Psychiatry (Ed. Española) , Volume 13 , Issue 8 , November 2006 , pp. 380 - 388
Copyright
Copyright © European Psychiatric Association 2006

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