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Depresión en la enfermedad de Alzheimer: ¿hay una relación temporal entre el comienzo de la depresión y el inicio de la demencia?

Published online by Cambridge University Press:  12 May 2020

Reinhard Heun ,
Martin Kockler  and
Ursula Ptok
Reinhard Heun
Affiliation:
Departamento de Psiquiatría de la Universidad de Bonn, Sigmund Freud Str. 25, 53105Bonn, Alemania
Martin Kockler
Affiliation:
Departamento de Psiquiatría de la Universidad de Bonn, Sigmund Freud Str. 25, 53105Bonn, Alemania
Ursula Ptok
Affiliation:
Departamento de Psiquiatría de la Universidad de Bonn, Sigmund Freud Str. 25, 53105Bonn, Alemania
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Resumen

Los pacientes con enfermedad de Alzheimer (EA) acuden a consulta a menudo por depresión mayor concurrente (DM). Para investigar las razones para esta comorbilidad, por ejemplo, que la DM sea un factor de riego para la EA o que ambos diagnósticos tengan características neurobiológicas comunes, se estudió la relación temporal entre el primer comienzo de la EA y de la DM en la vida del paciente; 57 de 146 pacientes con EA tenían un diagnóstico vital de DM. Se calculó la correlación entre las edades en el comienzo de la DM y la demencia. Se comparó la incidencia de DM en los pacientes con EA en varios intervalos de 5 años anteriores y posteriores al comienzo de la EA con la incidencia media de DM en la presente muestra de EA y con la incidencia esperada de DM en la población general. No se pudo encontrar una correlación significativa entre el comienzo de la EA y de la DM después de controlar la edad, el género y la puntuación del Mini Estado Mental. Sin embargo, la incidencia de DM los 5 años anteriores y posteriores al comienzo de la EA superó significativamente las incidencias esperadas: la DM se relaciona sólo parcialmente con la EA. Sin embargo, el aumento de incidencia de DM en los 5 años anteriores y posteriores al comienzo de la demencia puede indicar que un proceso neurobiológico común causa el declive cognitivo y la depresión en una submuestra de pacientes con EA.

Keywords

enfermedad de Alzheimerdepresión mayordemenciacomorbilidadedad en el comienzo
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 10 , Issue 1 , February 2003 , pp. 20 - 25
Copyright
Copyright © European Psychiatric Association 2003

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