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Asociación de los genes del receptor D2 de dopamina y del alcohol deshidrogenasa 2 con alcohólicos polinesios
Published online by Cambridge University Press: 12 May 2020
Resumen
Se determinaron los alelos de los genes del receptor D2 de dopamina (DRD2) y del alcohol deshidrogenasa 2 (ADH2) en 69 pacientes alcohólicos de la Polinesia francesa y 57 controles empa- rejados en cuanto a su origen racial. Se estudiaron tres grupos raciales: polinesios puros (PP), polinesios mezclados con ascendencia caucasiana (PACauc) y polinesios mezclados con ascendencia china (PACh). En estos grupos, las frecuencias del alelo Al del DRD2 en los alcohólicos en comparación con sus controles fueron: PP: 0,26 frente a 0,32 (P = 0,69); PACauc: 0,44 frente a 0,35 (P = 0,46); PACh: 0,40 frente a 0,39 (P = 0,88). Las frecuencias del alelo 1 de la ADH2 en alcohólicos en comparación con sus grupos de control fueron: PP: 0,56 frente a 0,62 (P = 0,66); PACauc: 0,75 frente a 0,56 (P = 0,09); PACh: 0,78 frente a 0,32 (P = 0,009). En el grupo de PACauc, la combinación de los geno- tipos Al del DRD2 y los homocigotos 1 de la ADH2 estaba fuertemente asociada con el alcoholismo (P = 0,0027). Este estudio preliminar muestra la importancia de comprobar la ascendencia racial en los estudios de asociación de genética molecular. Además, indica que en la susceptibilidad al desarrollo del alcoholismo está implicada una combinación de genes.
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References
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