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Uso auxiliar de la reboxetina en la esquizofrenia

Published online by Cambridge University Press:  12 May 2020

Thomas J. Raedler ,
Holger Jahn ,
Josef Arlt ,
Falk Kiefer ,
Mildred Schick ,
Dieter Naber  and
Klaus Wiedemann
Thomas J. Raedler
Affiliation:
Hospital Universitario de Hamburgo-Eppendorf, Departamento de Psiquiatría y Psicoterapia, Martini str. 52, 20246Hamburgo, Alemania
Holger Jahn
Affiliation:
Hospital Universitario de Hamburgo-Eppendorf, Departamento de Psiquiatría y Psicoterapia, Martini str. 52, 20246Hamburgo, Alemania
Josef Arlt
Affiliation:
Hospital Universitario de Hamburgo-Eppendorf, Departamento de Psiquiatría y Psicoterapia, Martini str. 52, 20246Hamburgo, Alemania
Falk Kiefer
Affiliation:
Hospital Universitario de Hamburgo-Eppendorf, Departamento de Psiquiatría y Psicoterapia, Martini str. 52, 20246Hamburgo, Alemania
Mildred Schick
Affiliation:
Hospital Universitario de Hamburgo-Eppendorf, Departamento de Psiquiatría y Psicoterapia, Martini str. 52, 20246Hamburgo, Alemania
Dieter Naber
Affiliation:
Hospital Universitario de Hamburgo-Eppendorf, Departamento de Psiquiatría y Psicoterapia, Martini str. 52, 20246Hamburgo, Alemania
Klaus Wiedemann
Affiliation:
Hospital Universitario de Hamburgo-Eppendorf, Departamento de Psiquiatría y Psicoterapia, Martini str. 52, 20246Hamburgo, Alemania
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Resumen

Antecedentes.

La esquizofrenia se complica con frecuencia por síntomas depresivos o negativos que responden sólo de manera moderada al tratamiento con los medicamentos antipsicóticos. La reboxetina es un antidepresivo nuevo que inhibe la recaptación de norepinefrina. Tratamos de estudiar la eficacia y tolerabilidad del uso auxiliar de la reboxetina en una cohorte de pacientes esquizofrénicos con síntomas depresivos o negativos prominentes.

Métodos.

Se seleccionó para este estudio a 16 pacientes esquizofrénicos hospitalizados. Todos los sujetos recibieron 4-8 mg/día de reboxetina mientras se continuaba la medicación antipsicótica (antipsicóticos típicos = 4; antipsicóticos atípicos = 12). Todos los sujetos pasaron una evaluación estandarizada que incluía la PANSS, la CGI, la HAMD y la CDSS antes y después del tratamiento con reboxetina (media: 26 ± 17 d).

Resultados.

Todos los sujetos toleraron el tratamiento con reboxetina. Los efectos adversos fueron leves y no requirieron la interrupción del fármaco. Todas las puntuaciones clínicas (PANSS: 93,1 frente a 63,1; CGI: 5,4 frente a 4,1; HAMD: 20,4 frente a 8,1, y CDSS: 12,5 frente a 4,6) mejoraron significativamente bajo el tratamiento auxiliar con reboxetina (todos P < 0,01).

Conclusión.

El uso auxiliar de reboxetina en los pacientes esquizofrénicos fue seguro y se toleró bien. Nuestros resultados indican que el uso auxiliar de reboxetina puede ser un tratamiento efectivo para los síntomas depresivos y negativos en la esquizofrenia.

Keywords

EsquizofreniaDepresiónSíntomas negativosAntidepresivosReboxetina
Type
Artículos Originales
Information
European Psychiatry (Ed. Española) , Volume 12 , Issue 2 , March 2005 , pp. 107 - 110
Copyright
Copyright © European Psychiatric Association 2005

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Footnotes

RedlerTJ. JahnH, ArltJ, KieferF, SchickM, NaberD, WiedemannK. Uso auxiliar de la reboxetina en la esquizofrenia. Eur Psychiatry2004; 19:366–369

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