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Una posible asociación entre el gen del receptor A de la CCK-RA y las alucinaciones auditivas persistentes en la esquizofrenia

Published online by Cambridge University Press:  12 May 2020

J. Sanjuán ,
I. Toirac ,
J. C. González ,
C. Leal ,
M. D. Moltó ,
C. Nájera  and
R. de Frutos
J. Sanjuán
Affiliation:
Unidad de Psiquiatría, Facultad de Medicina, Hospital Clínico, Blasco lbáñez 15, Universitat de Valencia, 46010Valencia, España
I. Toirac
Affiliation:
Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, España
J. C. González
Affiliation:
Unidad de Psiquiatría, Facultad de Medicina, Hospital Clínico, Blasco lbáñez 15, Universitat de Valencia, 46010Valencia, España
C. Leal
Affiliation:
Unidad de Psiquiatría, Facultad de Medicina, Hospital Clínico, Blasco lbáñez 15, Universitat de Valencia, 46010Valencia, España
M. D. Moltó
Affiliation:
Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, España
C. Nájera
Affiliation:
Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, España
R. de Frutos
Affiliation:
Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, España
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Resumen

Estudios recientes han propuesto que variaciones del ADN en el gen del receptor A de la pancreocimina (CCK-RA) podrían predisponer a los individuos a la esquizofrenia y particularmente a las alucinaciones auditivas’ (AA). El propósito de este estudio es evaluar la asociación entre las AA, utilizando una escala específica para ellas en la esquizofrenia (PSYRATS), y el polimorfismo del RA-CCK en 779 en una muestra española. Se estudió un total de 105 pacientes esquizofrénicos del DSM-IV con AA y 93 controles no relacionados. Se consideró que 22 pacientes tenían alucinaciones auditivas persistentes, y mostraban características clínicas y demográficas similares a los pacientes con AA episódicas, con la excepción de los valores de la PSYRATS. El grupo de AA persistentes mostró una mayor cantidad de alelo Al cuando se comparó con los grupos de alucinaciones episódicas o de control. Nuestros datos apoyan el posible papel del gen del RA-CCK en el desarrollo de AA persistentes en los pacientes esquizofrénicos.

Keywords

EsquizofreniaAlucinaciones auditivasReceptor A de la colecistokininaAlucinaciones persistentesAnálisis de asociación
Type
Artículos Originales
Information
European Psychiatry (Ed. Española) , Volume 12 , Issue 2 , March 2005 , pp. 94 - 98
Copyright
Copyright © European Psychiatric Association 2005

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Footnotes

SanjuanJ, ToiracI, GonzálezJC, LealC, MoltóMD, NájeraC, de FrutosR. Una posible asociación entre el gen del receptor A de la CCK-RA y las alucinaciones auditivas persistentes en la esquizofrenia. Eur Psychiatry2004;19:349–353.

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