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Potencial evocado cognitivo P300 y actividad del receptor 5-HT1A en la depresión
Published online by Cambridge University Press: 12 May 2020
Resumen
La identificación de las estructuras cerebrales y los neurotransmisores responsables de la generación de la onda P300, de su modulación o de ambas cosas, podría llevar a implicaciones clínicas importantes. Puesto que las perturbaciones de la serotonina parecen desempeñar un papel crítico en la depresión, el propósito del estudio era evaluar las posibles relaciones entre el potencial evocado cognitivo cerebral P300 y la actividad serotonérgica en la depresión. El estudio se realizó entre 45 pacientes hospitalizados con depresión mayor, y la actividad serotonérgica se evaluó por la respuesta de la prolactina (PRL) al flesinoxán (un agonista del receptor 5-HT1A). Los resultados mostraron una correlación negativa significativa entre la amplitud de la onda P300 y la respuesta de la PRL al flesinoxán (r = -0,40, P = 0,007 en Cz; r = -0,47, P = 0,001 en Pz). Por contraste, tanto la latencia de la onda P300 como el tiempo de reacción no estaban relacionados con la respuesta endocrina. Este estudio apoya la existencia de un papel para el receptor 5-HT1A en la modulación neurobiológica de la amplitud de la onda P300.
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References
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