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Lateralización anormal en esquizofrenia: datos empíricos para un modelo integrado

Published online by Cambridge University Press:  12 May 2020

N. Karny
Affiliation:
Centro de Rehabilitación y Salud Mental de Ness Ziona, Ness Ziona, asociado a la Escuela Sacklar de Medicina, Tel Aviv
I. Nachson
Affiliation:
Departamento de Criminología, Universidad Bar-Han, Ramat Gan, 52900Israel
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Resumen

Los déficit cerebrales en esquizofrenia se han asociado con disfunción del hemisferio izquierdo o con deterioro en la transferencia interhemisférica. Para examinar la eficacia relativa de las dos hipótesis, se dio a 63 sujetos diestros (24 esquizofrénicos paranoides, 21 esquizofrénicos no paranoides y 18 controles normales) dos tareas auditivas laterales: identificación de secuencias de sonidos y de conjuntos de dígitos presentados dicóticamente. Como mostraron los análisis de datos, los controles normales dieron más respuestas correctas que los pacientes, y los hombres, más respuestas correctas que las mujeres. Por lo general, el informe del oído derecho fue mejor que el del oído izquierdo y, en especial, fue mejor el informe del oído que se daba en segundo lugar. Esta ventaja del oído derecho (que fue más consistente en hombres que en mujeres“) fue anormalmente grande para los esquizofrénicos paranoides, que mostraron en ambas pruebas una ligera disminución en el informe del oído derecho y una disminución significativa en el informe del oído izquierdo en relación con los sujetos normales. Se interpretó que los datos indicaban disfunción del hemisferio izquierdo y daño estructural del cuerpo calloso en los esquizofrénicos paranoides.

Type
Artículo original
Copyright
Copyright © European Psychiatric Association 1995

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References

Bibliografía

Aharonovich, E, Karny, N, Nachson, I. Visual field processing in paranoid and non-paranoid schizophrenics. Eur Psychiatry 1993; 8: 301–7.Google Scholar
Altman, JA, Balonov, LJ, Deglin, VL. Effects of unilateral disorder of the brain hemisphere function in man on directional hearing. Neuropsychologia 1979; 17: 295301.Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (3rd edition, revised). Washington, DC, 1987.Google Scholar
Bakker, DJ, Schroots, JF. Temporal order in normal and disturbed children. In: Pavlidis, GT, Miles, TR, eds. Dyslexia Research and its Implications to Education. New York: Wiley, 1981; 8798.Google Scholar
Baldessarini, RJ. Chamotherapy in Psychiatry. Cambridge: Harvard University Press, 1985.Google Scholar
Beaumont, JG, Dimong, SJ. Brain disconnection and schizophrenia. Br J Psychiatry 1973; 123: 661–2.CrossRefGoogle Scholar
Bigelow, LB, Nasrallah, HA, Rauscher, FP. Corpus callosum thickness in chronic schizophrenia. Br J Psychiatry 1983; 142: 284–7.CrossRefGoogle ScholarPubMed
Blumstein, S, Goodglass, H, Tarter, J. The reliability of ear advantage in dichotic listening. Brain Lang 1975; 2: 226–36.CrossRefGoogle ScholarPubMed
Bruder, GE. Cerebral laterality and psychopathology: a review of dichotic listening studies. Schizophrenia Bull 1983; 9: 134–51.CrossRefGoogle ScholarPubMed
Bruder, GE. Dichotic listening in psychiatric patients. In: Hugdahl, K, ed. Handbook of Dichotic Listening: Theory, Methods and Research. Sussex, England: Wiley, 1988; 527–64.Google Scholar
Bryder, MP. Evidence for sex-related differences in cerebral organization. In: Witting, M, Peterson, AC, eds. Sex-Related Differences in Cognitive Functioning. New York: Academic Press 1979; 121–43.Google Scholar
Bryden, MP. Laterality: Functional Asymmetry in the Intact Brain. New York: Academic Press, 1982.Google Scholar
Bull, HC, Venables, PH. Speech perception in schizophrenia. Br J Psychiatry 1974; 125: 350–4.CrossRefGoogle Scholar
Carmon, A, Nachshon, I. Effect of unilateral brain damage on perception of temporal order. Cortex 1971; 7: 410–8.CrossRefGoogle ScholarPubMed
Carr, SA. Interhemispheric transfer of sterognostic information in chronic schizophrenia. Br J Psychiatry 1980; 136: 53–8.Google Scholar
Cutting, J.The Right Cerebral Hemisphere and Psychiatric Disorders. Oxford: Oxford University Press, 1990.Google Scholar
Caudrey, DJ, Kirk, K. The perception of speech in schizophrenia and affective disorders. In: Gruzelier, J, Flor-Henry, P, eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier 1979; 581602.Google Scholar
Clooney, JL, Murray, DJ. Same-different judgments in paranoid and schizophrenic patients: a laterality study. J Abnorm Psychol 1977; 86: 655–8.Google ScholarPubMed
Colbourn, CJ, Lishman, WA. Lateralization of function and psychotic illness: a left hemisphere déficit. In: Gruzelier, J, Flor-Henry, P, eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier 1979; 539–60.Google Scholar
Connoly, JF, Gruzelier, JH, Kleinman, KM, Hirsch, SR. Lateralized abnormalities in hemisphere-specific tachistoscopic tasks in psychiatric patients and controls. In: Gruzelier, J, Flor-Henry, P, eds. Hemisphere Asymmetry of Function in Psychopathology. Amsterdam: Elsevier 1979; 491510.Google Scholar
Connoly, JF, Gruzelier, JH, Manchanda, R. Electrocortical and perceptual asymmetries in schizophrenia. In: Flor-Henry, P, Gruzelier, J, eds. Laterality and Psychopathology. Amsterdam: Elsevier 1983; 363–78.Google Scholar
Coren, S, Porac, C, Duncan, P. A behaviorally validated self-report inventory to assess four types of lateral preference. J Clin Neuropsychol 1979; 1: 5584.Google Scholar
Damasio, H, Damasio, AR, Castro-Caldas, A, Ferro, JM. Dichotic listening pattern in relation to interhemispheric disconnexion. Neuropsychologia 1976; 14: 247–50.CrossRefGoogle ScholarPubMed
David, AS. Tachistoscopic tests of colour naming and matching in schizophrenia: evidence for posterior callosum dysfunction? Psychol Med 1987; 17: 621–30.CrossRefGoogle ScholarPubMed
David, AS. Callosal transfer in schizophrenia: too much or too little? J Abnorm Psychol 1993; 102: 573–9.CrossRefGoogle ScholarPubMed
Dimond, S.Disconnection and psychopathology. In: Gruzelier, J, Flor-Henry, P, eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier 1979; 3546.Google Scholar
Dimond, SJ, Scammel, RE, Pryce, IG, Huws, D, Gray, C. Callosal transfer and left-hand anomia in schizophrenia. Biol Psychiatry 1979; 14: 735–9.Google Scholar
Dimond, SJ, Scammel, RE, Pryce, IG, Huws, D, Gray, C. Some failure of intermanual and cross-lateral transfer in chronic schizophrenia. J Abnorm Psychol 1980; 89: 505–9.Google Scholar
Eaton, EM, Bush, JK, Maloney, MP, Sloane, RB, Wipple, K, White, K. Hemispheric dysfunction in schizophrenia: assessment by visual perception tasks. Psychiatr Res 1979; 1: 315–32.CrossRefGoogle ScholarPubMed
Efron, R. Temporal perception, aphasia, and Deja Vu. Brain 1963; 86: 403–24.CrossRefGoogle Scholar
Flor-Henry, P. Cerebral Basis of Psychopathology. Boston: Wright, 1983.Google Scholar
Flor-Henry, P, Koles, ZJ. EEG studies in depression, mania and normáis: evidence for partial shifts of laterality in the affective psychoses. Adv Biol Psychiatry 1980; 4: 2143.CrossRefGoogle Scholar
Flor-Henry, P, Gruzelier, J, eds. Laterality and Psychopathology. Amsterdam: Elsevier, 1983.Google Scholar
Goldman, PS, Lodge, A, Hammer, LR, Semmes, J, Mishkin, M. Critical flicker frequency after unilateral temporal lobectomy in man. Neuropsychologia 1968; 6: 355–63.CrossRefGoogle Scholar
Gordon, HW. Cerebral organization in bilinguals. Brain Lang 1980; 9: 255–68.Google ScholarPubMed
Green, P. Defective interhemispheric transfer and schizophrenia. J Abnorm Psychol 1978; 87: 472–80.CrossRefGoogle Scholar
Green, P, Glass, AO'Callaghan, M. Some implications of abnormal hemisphere interaction in schizophrenia. In: Gruzelier, J, Flor-Henry, P, eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier 1979; 431–48.Google Scholar
Green, M. Walker, E. Attentional performance in positive and negative-symptom schizophrenia. J Nerv MentDis 1986; 174:208–13.CrossRefGoogle ScholarPubMed
Gruzelier, J. Bimodal states of arousal and lateralized dysfunction in schizophrenia: effects of chlorpromazine. In: Wynne, LC, Cromwell, RL, Matthysse, S, eds. The Nature of Schizophrenia: New Approaches to Treatment. New York: Wiley 1978; 167–83.Google Scholar
Gruzelier, J. Theories of lateralized and interhemispheric dysfunction in syndromes of schizophrenia. In: Burrows, GD, Rubenstein, NG, eds. Handbook of Studies in Schizophrenia. Pt. 2. Amsterdam: Elsevier 1986; 175–96.Google Scholar
Gruzelier, JH, Hammond, NV. Schizophrenia: a dominant hemisphere temporal-limbic disorder? Res Commun Psychol Psychiatr Behav 1976; 1: 3372.Google Scholar
Gruzelier, JH, Hammond, NV. The effect of chlorpromazine upon bilateral asymmetries in biolectrical skin reativity of schizophrenics. Studia Psychologica 1971; 19: 40-51.Google Scholar
Gruzelier, JH, Hammond, NV. The effect of chlorpromazine upon psychophysiological endocrine and information processing measures in schizophrenia. J Psychiatr Res 1978; 14: 167–82.CrossRefGoogle Scholar
Gruzelier, J, Flor-Henry, P, eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier, 1979.Google Scholar
Gruzelier, JH, Hammond, NV. Lateralized déficits and drug infiuences on the dichotic listening of schizophrenic patients. Biol Psychiatry 1980; 15: 759–79.Google Scholar
Gulman, NC, Wildschiodtz, G, Orbaek, K. Alteration of interhemispheric conduction through corpus callosum in chronic schizophrenia. Biol Psychiatry 1982; 17: 585–94.Google Scholar
Gur, RE. Motoric laterality imbalance in schizophrenics: a possible concomitant of left hemisphere dysfunction. Arch Gen Psychiatry 1977; 34: 33–7.CrossRefGoogle ScholarPubMed
Gur, RE. Left hemisphere dysfunction and left hemisphere overactivation in schizophrenia. Abnorm Psychol 1978; 87: 226–38.CrossRefGoogle Scholar
Gur, RE. Cognitive concomitants of hemispheric dysfunction in schizophrenia. Arch Gen Psychiatry 1979a; 36: 269–74.CrossRefGoogle Scholar
Gur, RE. Hemispheric overactivation in schizophrenia. In: Grupzelier, J, Flor-Henry, P, eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam: Elsevier, 1979b; 113-24.Google Scholar
Hallett, S. Quinn, D, Hewitt, J. Defective interhemispheric integration and anomalous language lateralization in children at risk for schizophrenia. Nerv Ment Dis 1986; 174:418–27.CrossRefGoogle ScholarPubMed
Halperin, Y, Nachshon, I. Carmon, A.Shift of ear superiority in dichotic listening to temporally patterned nonverbal stimuli. J Acoust Soc Am 1973; 53: 4650.CrossRefGoogle ScholarPubMed
Hammond, NV, Gruzelier, JH. Laterality, attention, and rate effects in the auditory temporal discrimination of chronic schizophrenics: the effect of treatment with chlorpromazine. Q J Exp Psychol 1978; 30: 91103.CrossRefGoogle ScholarPubMed
Hatta, T, Ayetani, N, Yoshizaki, K. Dichotic listening by chronic schizophrenic patients. Intern J Neurosci 1984a; 23: 7580.CrossRefGoogle Scholar
Hatta, T, Yamamoto, M, Kawabata, Y. Functional hemispheric differences in schizophrenia: interhemispheric transfer deficit or selective hemisphere dysfunction? Biol Psychiatry 1984b; 19: 1027–36.Google Scholar
Hiramatsu, KI, Kameyama, T, Saitoh, O, Niwa, SI. Correlations of event related potentials with schizophrenic déficits in information processing and hemisphere dysfunction. Biol Psychol 1984; 19: 281–94.CrossRefGoogle Scholar
Hugdahl, K, ed. Handbook of Dichotic Listening: Theory, Methods and Research. Sussex, England: Wiley, 1988.Google Scholar
Ingvar, DH. Functional landscapes of the dominant hemisphere. Brain Res 1986; 107: 181–97.Google Scholar
Johnson, O, Crockett, D. Changes in perceptual asymmetries with clinical improvement of depression and schizophrenia. J Abnorm Psychol 1982; 91: 4554.CrossRefGoogle Scholar
Kimura, D.Cerebral dominance and the perception of verbal stimuli. Can J Psychol 1961a; 15: 166–71.CrossRefGoogle Scholar
Kimura, D.Some effects of temporal lobe damage on auditory perception. Can J Psychol 1961b; 15: 156–65.CrossRefGoogle Scholar
Kimura, D. Left-right differences in the perception of melodies. QJ Psychol 1964; 16: 355–8.Google Scholar
Kimura, D.Are men's and women's brains really different? Can Psychol 1987; 28: 133–47.CrossRefGoogle Scholar
Kinsbourne, M. The normal and deviant development of functional lateralization of the brain. In: Mussen PH, ed. Handbook of Clinical Psychology (4th ed), Vol 2. Infancy and Developmental Psychology (MM Haith, JJ Campos, volume editors). New York: Wiley, 1983; 158280.Google Scholar
Kraft, RH. Relationship of ear specialization to degree of task difficulty, sex, and lateral preference. PerceptMot Skills 1982; 54: 703–14.CrossRefGoogle ScholarPubMed
Kugler, BT. Auditory processing in shizophrenic patients. In: Flor-Henry, P, Gruzelier, J, eds. Laterality and Psychopathology. Amsterdam: Elsevier 1983; 471506.Google Scholar
Lerner, J, Nachshon, J, Carmon, A. Responses of paranoid and nonparanoid schizophrenics on a dichotic listening task. J Nerv Ment Dis 1977; 164: 247–52.CrossRefGoogle ScholarPubMed
Lishman, WA, Toone, BK, Colbourn, CJ, McMeekan, ERL, Manee, RM. Dichotic listening in psychotic patients. Br J Psychiatry 1978; 132: 333–41.CrossRefGoogle ScholarPubMed
Magaro, PA. Cognition in schizophrenia and paranoia: the integration of cognitive processes. Hillsdale, NJ: Erlbaum, 1980.Google Scholar
Magaro, PA. The pranoid and the schizophrenic: the case for distinctive cognitive style. Schizophr Bull 1981; 7: 632–61.CrossRefGoogle ScholarPubMed
Magaro, PA, Chamrad, DL. Information processing and lateralization in schizophrenia. Biol Psychiatry 1983; 18: 2944.Google Scholar
Marin, RS. Tucker, GJ. Psychopathology and hemispheric dysfunction: a review. J Nerv Ment Dis 1981; 169:546–57.CrossRefGoogle ScholarPubMed
McGlone, J.The neuropsychology of sex differences in human brain organization. In: Glodstein, G, Tarter, RE, eds. Advances in Clinical Neuropshology, vol 3. New York: Plenum, 1986; 130.Google Scholar
Merrin, EL. Schizophrenia and brain asymmetry: an evaluation of evidence for dominant lobe dysfunction. J Nerv Ment Dis 1981; 169: 405–16.CrossRefGoogle ScholarPubMed
Milner, B, Taylor, L, Sperry, RW. Lateralized suppression of dichotically presented digits after commissual section in man. Science 1968; 161: 184–6.CrossRefGoogle ScholarPubMed
Moscovitch, M.Information processing and cerebral hemispheres. In: Gazzaniga, MS., ed. Handbook of Behavioral Biology, vol 2, New York: Plenum, 1979; 379446.Google Scholar
Myslobodsky, MS, Mintz, M, Tomer, R. Neuroleptic effects and the site of abnormality in schizophrenia. In: Myslobodsky, MS, ed. Hemisyndrome: Psychobiology, Neurology, Psychiatry. New York: Academic Press 1983; 347–88.Google Scholar
Nachshon, I. Effects of cerebral dominance and attention on dichotic listering. J LifeSci 1973; 3: 107–14.Google Scholar
Nachshon, I: Hemispheric dysfunctioning in schizophrenia. J Nerv Ment Dis 1980; 168: 241–2.CrossRefGoogle Scholar
Nachshon, I.Cross-cultural differences in laterality. Intern J Neurosa 1986a; 30: 291–5.CrossRefGoogle Scholar
Nachshon, I.Cross-language differences in dichotic listening. Intern J Psychology 1986b; 21: 617–25.CrossRefGoogle Scholar
Nachshon, I.Dichotic listening models of cerebral deficits in schizophrenia. In: Hugdahl, K., ed. Handbook Of Dichotic Listening: Theory, Methods and Research. Sussex, England: Wiley 1988; 565–94.Google Scholar
Nachshon, I, Carmon, A. Effect of stimulus-response delay on ear superiority for dichotically presented digits. J Exp Psychol 1973; 99: 288–90.CrossRefGoogle ScholarPubMed
Nachson, I, Harel, S. Dichotic listening to temporal stimuli by children with reading disabilities. 1995 (submitted for publication).Google Scholar
Nasrallah, HA. Laterality and hemisphere dysfunction in schizophrenia. In: Henns, FA, Nasrallah, HA, eds. Schizophrenia as a Brain Disease. New York: Oxford University Press 1982; 273–94.Google Scholar
Nasrallah, HA, McCalley-Whitters, M, Bigelow, LB, Rauscher, FPA. Histological study of the corpus callosum in chronic schizophrenia. Psychiatr Res 1983; 8: 251–60.CrossRefGoogle ScholarPubMed
Newlin, DB, Carpenter, B, Golden, CJ. Hemispheric asymmetries in schizophrenia. Biol Psychiatry 1981; 16: 561–82.Google Scholar
Raine, A, Andrews, H, Sheard, C, Walder, C, Manders, D. Interhemispheric transfer in schizophrenics, depressives, and normáis with schizoid tendencies. J Abnorm Psychol 1989; 98: 3541.CrossRefGoogle Scholar
Randall, PL. A neuroanatomical theory on the etiology of schizophrenia. Medical Hypotheses 1967; 3: 645–58.Google Scholar
Rosenthal, R, Bigelow, LB. Quantitative brain measurement in chronic schizophrenia. Br J Psychiatry 1972; 121: 259–64.CrossRefGoogle Scholar
Satz, P, Achenbach, K, Pattishall, E, Fennell, E. Order of report, ear asymmetry and handedness in dichotic listening. Cortex 1965; 1: 377–96.CrossRefGoogle Scholar
Schulhoff, C, Goodglass, H. Dichotic listening, side of brain injury and cerebral dominance. Neuropsychologia 1969; 7: 149–60.CrossRefGoogle Scholar
Schweitzer, L. Differences of cerebral lateralization among schizophrenic and depressed patients. Biol Psychiatry 1979; 14: 721–33.Google ScholarPubMed
Schweitzer, L. Evidence of right cerebral hemisphere dysfunction in schizophrenic patients with left hemisphere overactivation. Biol Psychiatry 1982; 17: 655–73.Google ScholarPubMed
Schweitzer, L, Becker, E, Welsh, H. Abnormalities of cerebral lateralization in schizophrenic patients. Arch Gen Psychiatry 1978; 35: 982–5.CrossRefGoogle Scholar
Serafetinides, EA. Laterality and voltage in the EEG of psychiatric patients. Dis Nerv System 1972; 33: 622–3.Google ScholarPubMed
Serafetinides, EA. Voltage laterality in the EEG of psychiatric patients. Dis Nerv System 1973; 34: 190–1.Google ScholarPubMed
Sparks, R, Geschwind, N. Dichotic listening in man after section of neocortical commissures. Cortex 1968; 4: 316.CrossRefGoogle Scholar
Springer, SP, Gazzaniga, MS. Dichotic testing of partial and complete split brain subjects. Neuropsychologia 1975; 13: 341–6.CrossRefGoogle ScholarPubMed
Springer, SP, Sidtis, J, Wilson, D, Gazzaniga, MS. Left ear performance in dichotic listening following commissurotomy. Neuropsychologia 1978; 16: 305–12.CrossRefGoogle ScholarPubMed
Stratta, P, Rossi, A, Gallucci, M, Amicarelli, I, Passariello, R, Casacchia, M. Hemispheric asymmetries and schizophrenia: a preliminary magnetic resonance imaging study. Biol Psychiatry 1989; 25: 275–84.CrossRefGoogle ScholarPubMed
Takahashi, R, Flor-Henry, P, Gruzelier, J, Niwa, S, eds. Cerebral Dynamics, Laterality and Psychopathology. Amsterdam: Elsevier, 1987.Google Scholar
Tanno, Y, Machiyama, Y. Left hemisphere underactivation in schizophrenia: neuropsychologial investigation by means of the letter-shape composite stimuli test. In: Takahashi, R, Flor-Henry, P, Gruzelier, J, Niwa, S, eds. Cerebral Dynamics, Laterality and Psychopathology. Amsterdam: Elsevier 1987; 331–2.Google Scholar
Tomer, M. Asymmetrical effects of neuroleptics on psychotic patients: performance of a tactile discrimination task. J Nerv Ment Dis 1989; 177: 699700.CrossRefGoogle ScholarPubMed
Tomer, M, Flor-Henry, P. Neuroleptic reverse attention asymmetries in schizophrenic patients. Biol Psychiatry 1989; 25: 852–60.CrossRefGoogle ScholarPubMed
Tress, KH, Caudrey, DJ, Mehta, B. Tactile evoked potentials in schizophrenia: interhemispheric transfer and drug effects. Br J Psychiatry 1983; 143: 156–64.CrossRefGoogle ScholarPubMed
Tucker, DM. Lateral brain function, emotion, and conceptualization. Psychol Bull 1981; 89: 1946.CrossRefGoogle ScholarPubMed
Walker, E, Hoppes, E, Emory, E. A reinterpretation of findings on hemispheric dysfunction in schizophrenia. J Nerv Ment Dis 1981; 169: 378–80.CrossRefGoogle Scholar
Walker, E, McGuire, M. Bilateral processing of visual and auditory stimuli by psychotic patients: a study of the nature and extent of performance asymmetries. Res Commun Psychol Psychiatr Behav 1982a; 7:441–61.Google Scholar
Walker, E, McGuire, M. Intra- and interhemisphere information processing in schizophrenia. Psychol Bull 1982b; 92: 701–25.CrossRefGoogle Scholar
Wexler, BE, Heninger, GR. Alterations in cerebral laterality during acute psychotic illness. Arch Gen Psychiatry 1979; 36: 278–84.CrossRefGoogle ScholarPubMed
Yozawitz, A, Bruder, G, Sutton, S, Sharpe, L, Gurland, B, Fleiss, J, Costa, L. Dichotic perception: evidence for right hemisphere dysfunction in affective psychosis. Br J Psychiatry 1979; 135: 224–37.CrossRefGoogle ScholarPubMed