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Investigatión cerebral de hermanos sanos de pacientes esquizofrénicos

Published online by Cambridge University Press:  12 May 2020

A. Mourot ,
T. d'Amato ,
T. Rochet ,
M. Marie-Cardine ,
C. Artéaga ,
J. P. Martin  and
J. Dalery
A. Mourot
Affiliation:
CHS de Saint-Avé, 56890Saint-Avé
T. d'Amato
Affiliation:
CHS le Vinatier, 69677Bron
T. Rochet
Affiliation:
CHS le Vinatier, 69677Bron
M. Marie-Cardine
Affiliation:
CHS le Vinatier, 69677Bron
C. Artéaga
Affiliation:
Hôpital d'Instruction des Armées de Desgenettes, 69003Lyon, Francia
J. P. Martin
Affiliation:
Hôpital d'Instruction des Armées de Desgenettes, 69003Lyon, Francia
J. Dalery
Affiliation:
CHS le Vinatier, 69677Bron
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Resumen

Los estudios de tomografía computerizada (TC) han demostrado que el tamaño de los ventrículos laterales medido por la proporción ventrículo-cerebro (PVC), así como la anchura del tercer ventrículo, son estadísticamente mayores en los pacientes esquizofrénicos. Además, estas anomalías cerebrales difieren según los síntomas valorados con una escala de síntomas positivos y negativos. El propósito de este estudio era investigar, utilizando exploraciones de TC, a hermanos sanos de pacientes esquizofrénicos y relacionar los resultados con sus hermanos enfermos. Diecinueve hermanos sanos de 12 esquizofrénicos que habían sido estudiados con anterioridad sufrieron exploraciones de TC, que se compararon con las de su hermano esquizofrénico y con 17 sujetos de control no relacionados. Los resultados mostraron que, en 10 de las 12 familias, los esquizofrénicos tienen ventrículos (laterales y tercero) más grandes que sus hermanos sanos. La dilatatión ventricular de los hermanos sanos estaba correlacionada con la gravedad de los síntomas negativos de su hermano enfermo. Se debaten las implicaciones de una contributión familiar al tamaño ventricular y los síntomas negativos.

Keywords

exploración de TCproporción ventrículo-cerebrotercer ventrículoesquizofreniasíntomas negativos
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 5 , Issue 1 , February 1998 , pp. 36 - 42
Copyright
Copyright © European Psychiatric Association 1998

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