Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-07T18:36:59.507Z Has data issue: false hasContentIssue false

El polimorfismo TaqIA asociado al gen del receptor D2 de dopamina está relacionado con una atención más baja y menos control inhibitorio en los pacientes alcohólicos

Published online by Cambridge University Press:  12 May 2020

R. Rodríguez-Jiménez
Affiliation:
Unidad de Conductas Adictivas (UCA), Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041Madrid, España
C. Ávila
Affiliation:
Dpto. Psicología Básica, Clínica y Psicobiología, Universitat Jaime I, Castelló, España
G. Ponce
Affiliation:
Unidad de Conductas Adictivas (UCA), Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041Madrid, España
M. I. Ibáñez
Affiliation:
Dpto. Psicología Básica, Clínica y Psicobiología, Universitat Jaime I, Castelló, España
G. Rubio
Affiliation:
Servicios de Salud Mental, Retiro, Madrid, España
M. A. Jiménez-Arriero
Affiliation:
Unidad de Conductas Adictivas (UCA), Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041Madrid, España
I. Ampuero
Affiliation:
Facultad de Medicina, Universidad Complutense de Madrid, Madrid, España
J. A. Ramos
Affiliation:
Facultad de Medicina, Universidad Complutense de Madrid, Madrid, España
J. Hoenicka
Affiliation:
Unidad de Conductas Adictivas (UCA), Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041Madrid, España
T. Palomo
Affiliation:
Unidad de Conductas Adictivas (UCA), Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041Madrid, España
Get access

Resumen

El polimorfismo TaqIA vinculado al gen del receptor D2 de dopamina se ha asociado con el alcoholismo. El propósito de este trabajo es estudiar la atención y el control inhibitorio mediante el test de ejecución continua y la tarea de detención en una muestra de 50 pacientes varones alcohólicos españoles divididos en dos grupos segύn la presencia del alelo TaqIA1 en su genotipo. Nuestros resultados muestran que los alcoholicos portadores del alelo TaqIA1 presentan atención sostenida más baja y menos control inhibitorio que los pacientes sin ese alelo.

Type
Comunicación breve
Copyright
Copyright © European Psychiatric Association 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ávila, CParcet, MA. Personality and inhibitory deficits in the stopsignal task: the mediating role of Gray's anxiety and impulsivity. Person Individ Diff 2001;29:975–86.CrossRefGoogle Scholar
Barkley, RA. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 1997;121:6594.CrossRefGoogle ScholarPubMed
Blum, KBraverman, ERDinardo, MJWood, RCSheridan, PJ. Prolonged P300 latency in a neuropsychiatric population with the D2 dopamine receptor Al aliele. Pharmacogenetics 1994;4:313–22.CrossRefGoogle Scholar
Blum, KNoble, EPSheridan, PJMontgomery, ARitchie, TJagadeeswaran, P, et al.Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 1990;263:2055–60 (disorders).CrossRefGoogle ScholarPubMed
Cattell, RBCattell, AKS. Measuring intelligence with the culture fair tests. Manual for scales 2 and 3. Champaign, Illinois, USAI.PA.T; 1973.Google Scholar
Comings, DEComings, BGMuhleman, DDietz, GShahbahrami, BTast, D, et al.The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA 1991;266:1793–800.CrossRefGoogle ScholarPubMed
Connor, JPYoung, RMLawford, BRRitchie, TLNoble, EP. D2 dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence. Eur Psychiatry 2002;17:1723.CrossRefGoogle ScholarPubMed
Cordero, ACruz, MVGonzalez, MSeisdedos, N. Tests de factor “g”. Escalas 2 y 3 (RB Canell, AKS Cattell). Madrid, Spain: TEA Edicione. S.A; 1986.Google Scholar
Evenden, JL. Varieties of impulsivity. Psychopharmacology (Berl) 1999;146:348–61.CrossRefGoogle ScholarPubMed
Firsts, MBSpitzer, RLGibbon, MWilliams, JBW. Structured Clinical Interview for DSM-IV axis I disorders patient edition (SCID-IP, Version 2.0). New York, NY: Biometric Research, New York State Psychiatri Institute; 1995.Google Scholar
Hill, SYLocke, JZezza, NKaplan, BNeiswanger, KSteinhauer, SR, et al.Genetic association between reduced P300 amplitude and the DRD2 dopamine receptor A 1 aliele in children at high risk for alcoholism. Biol Psychiatry 1998;43:4051.CrossRefGoogle Scholar
Jönsson, EGNothen, MMGrunhage, FFarde, LNakashima, YPropping, P, et al.Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol Psychiatry 1999;4:290–6.CrossRefGoogle ScholarPubMed
Laine, TPAhonen, ARasanen, PPohjalainen, TTiihonen, JHietala, J. The Al aliele of the D2 dopamine receptor gene is associated with high dopamine transportar density in detoxified alcoholics. Alcohol Alcohol 2001;36:262–5.CrossRefGoogle Scholar
Limosin, FLoze, JYDubertret, CGouya, LAdes, JRouillon, F, et al.Impulsiveness as the intermediate link between the dopamine receptor D2 gene and alcohol dependence. Psychiatr Genet 2003;13:127–9.CrossRefGoogle ScholarPubMed
Milin, RLoh, EChow, JWilson, A. Assessment of symptoms of attention- deficit hyperactivity disorder in adults with substance use disorders. Psychiatr Serv 1997;48:1378–80.Google ScholarPubMed
Noble, EP. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet 2003;116(Suppl 1): 103–25.CrossRefGoogle Scholar
Noble, EPBerman, SMOzkaragoz, TZRitchie, T. Prolonged P300 latency in children with the D2 dopamine receptor A 1 aliele. Am J Hum Genet 1994;54:658–68.Google Scholar
Noble, EPBlum, KRitchie, TMontgomery, ASheridan, PJ. Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 1991;48:648–54.CrossRefGoogle ScholarPubMed
Noble, EPGottschalk, LAFallon, JHRitchie, TLWu, JC. D2 dopamine receptor polymorphism and brain regional glucose metabolism. Am J Med Genet 1997;74:162–6.3.0.CO;2-W>CrossRefGoogle ScholarPubMed
Noble, EPSyndulko, KFitch, JRitchie, TBohman, MGuth, P, et al.D2 dopamine receptor Taq 1 alieles in medically ill alcoholic and nonalcoholic patients. Alcohol Alcohol 1994;29:729–44.Google Scholar
Pobjalainen, TRinne, JONagren, KLehikoinen, PAnttila, KSyvalahti, EK, et al.The Al aliele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Mol Psychiatry 1998;3:256–60.CrossRefGoogle Scholar
Ponce, GHoenicka, JRodriguez-Jimenez, RGozalo, AJimenez, MMonasor, R, et al.IDRD2 TaqIA polymorphism is associated with urinary homovanillic acid levels in a sample of Spanish male alcoholic patients. Neurotox Res 2004;6:373–7.CrossRefGoogle Scholar
Ponce, GJimenez-Arriero, MARubio, GHoenicka, JAmpuero, IRamos, JA, et al.The Al aliele of the DRD2 gene (Taql A polymorphisms) is associated with antisocial personality in a sample of alcoholdependent patients. Eur Psychiatry 2003;18:356–60.CrossRefGoogle Scholar
Ponce, GRodriguez-Jimenez, RPerez, JAMonasor, RRubio, GJimenez-Arriero, MA, et al.Attention-deficit hyperactivity disorder and vulnerability to the development of alcoholism: use of the Wender- Utah Rating Scale for retrospective diagnostic of ADHD in the childhood of alcoholic patients. Actas Esp Psiquiatr 2000;28:357–66.Google Scholar
Wood, DWender, PHReimber, RW. Prevalence of attention deficit disorder, residual type, or minimal brain dysfunction, in a population of male alcoholic patients. Am J Psychiatry 1983;140:95–8.Google ScholarPubMed