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Atenuación de la indefensión aprendida en ratas después del trasplante de médula adrenal en la médula espinal

Published online by Cambridge University Press:  12 May 2020

P. Tejedor-Real ,
J.A. Micó ,
J. P. Corbalán ,
I. Ruz-Franzi ,
J. M. González-Darder  and
J. Gibert-Rahola
P. Tejedor-Real
Affiliation:
Departamento de Neurociencias, Escuela de Medicina, Universidad de Cádiz, Cádiz, España
J.A. Micó
Affiliation:
Departamento de Neurociencias, Escuela de Medicina, Universidad de Cádiz, Cádiz, España
J. P. Corbalán
Affiliation:
Departamento de Neurociencias, Escuela de Medicina, Universidad de Cádiz, Cádiz, España
I. Ruz-Franzi
Affiliation:
Departamento de Neurociencias, Escuela de Medicina, Universidad de Cádiz, Cádiz, España
J. M. González-Darder
Affiliation:
Departamento de Neurociencias, Escuela de Medicina, Universidad de Cádiz, Cádiz, España
J. Gibert-Rahola
Affiliation:
Departamento de Neurociencias, Escuela de Medicina, Universidad de Cádiz, Cádiz, España
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Resumen

Se examinó la influencia de un trasplante medular adrenal en el espacio subaracnoideo lumbar sobre la indefensión aprendida, un modelo animal de depresión. Se encontró que las ratas trasplantadas eran menos susceptibles de sufrir indefensión de choques inescapables después de la administración que los animales con un falso trasplante. El efecto se atribuyó a la liberación de péptidos opioides por células cromafines, pues Io invirtió la naloxona. La viabilidad del tejido trasplantado se verificó por microscopio electrónico.

Keywords

trasplante medular adrenalpéptidos opioidesnaloxonaindefensión aprendidadepresiónrata
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 4 , Issue 2 , March 1997 , pp. 107 - 111
Copyright
Copyright © European Psychiatric Association 1997

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