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Actividad de la monoaminooxidasa plaquetaria en el trastorno obsesivo compulsivo

Published online by Cambridge University Press:  01 April 2008

Manuel Arrojo ,
Enrique Baca-Garcia ,
María Mercedes Pérez-Rodríguez ,
Helen Dolengevich-Segal ,
Mercedes Navío-Acosta ,
Beatriz Rodríguez-Salgado  and
Jerónimo Sáiz-Ruiz
Manuel Arrojo
Affiliation:
Departamento de Psiquiatría, Hospital Ramón y Cajal, Carretera de Colmenar Viejo Km 9, 1, 28034Madrid, España
Enrique Baca-Garcia
Affiliation:
Departamento de Neurociencia, Centro Médico de la Universidad de Columbio, 1051 Riverside Drive, Suite 2917/Unidad 42, Nueva York Nueva York10032, Estados Unidos Departamento de Psiquiatría, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040Madrid, España
María Mercedes Pérez-Rodríguez
Affiliation:
Departamento de Psiquiatría, Hospital Ramón y Cajal, Carretera de Colmenar Viejo Km 9, 1, 28034Madrid, España
Helen Dolengevich-Segal
Affiliation:
Departamento de Psiquiatría, Hospital Ramón y Cajal, Carretera de Colmenar Viejo Km 9, 1, 28034Madrid, España
Mercedes Navío-Acosta
Affiliation:
Departamento de Psiquiatría, Hospital Ramón y Cajal, Carretera de Colmenar Viejo Km 9, 1, 28034Madrid, España
Beatriz Rodríguez-Salgado
Affiliation:
Departamento de Psiquiatría, Hospital Ramón y Cajal, Carretera de Colmenar Viejo Km 9, 1, 28034Madrid, España
Jerónimo Sáiz-Ruiz
Affiliation:
Departamento de Psiquiatría, Hospital Ramón y Cajal, Carretera de Colmenar Viejo Km 9, 1, 28034Madrid, España Departamento de Psiquiatría, Facultad de Medicina, Universidad Autónoma de Madrid, Calle Arzobispo Morcillo, 28029Madrid, España
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Resumen

La respuesta a los ISRS sugiere que el sistema serotoninérgico está implicado en el trastorno obsesivo compulsivo (TOC). Sin embargo, los estudios biológicos sobre la función serotoninérgica en TOC han dado resultados contradictorios. Se ha propuesto que la actividad monoaminooxidasa (MAO) plaquetaria es un índice de la actividad serotonérgica cerebral.

El objetivo de este estudio fue evaluar la actividad MAO plaquetaria en 29 pacientes con TOC y en 29 controles sanos apareados por edad, sexo y consumo de tabaco. También exploramos la relación entre la actividad MAO plaquetaria y las obsesiones agresivas en pacientes con TOC. No se encontró ninguna diferencia en la actividad MAO plaquetaria entre los pacientes con TOC y los controles sanos.

Encontramos una correlación significativa entre la actividad MAO plaquetaria y las puntuaciones de Y-BOCS en el grupo de pacientes con puntuaciones de Y-BOCS > 15.

Los pacientes con TOC y obsesiones agresivas tenían unos niveles significativamente menores de actividad MAO plaquetaria que los pacientes sin obsesiones agresivas.

Nuestros resultados indican que la actividad MAO plaquetaria puede ser un marcador de la gravedad del TOC, y que la actividad MAO plaquetaria baja puede asociarse con obsesiones agresivas en pacientes con TOC.

Keywords

Trastorno obsesivo compulsivoActividad MAO plaquetariaSerotoninaAgresion
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 15 , Issue 3 , April 2008 , pp. 125 - 129
Copyright
Copyright © European Psychiatric Association 2008

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