Simple and systematic algorithms for relating differential equations are given. They are based on comparing the local symmetries admitted by the equations. Comparisons of the infinitesimal generators and their Lie algebras of given and target equations lead to necessary conditions for the existence of mappings which relate them. Necessary and sufficient conditions are presented for the existence of invertible mappings from a given nonlinear system of partial differential equations to some linear system of equations with examples including the hodograph and Legendre transformations, and the linearizations of a nonlinear telegraph equation, a nonlinear diffusion equation, and nonlinear fluid flow equations. Necessary and sufficient conditions are also given for the existence of an invertible point transformation which maps a linear partial differential equation with variable coefficients to a linear equation with constant coefficients. Other types of mappings are also considered including the Miura transformation and the invertible mapping which relates the cylindrical KdV and the KdV equations.