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Propofol as a continuous infusion during cardiopulmonary bypass does not affect changes in serum free fatty acids

Published online by Cambridge University Press:  16 August 2006

S. Inoue ,
Y. Takauchi ,
Y. Kayamori ,
M. Kuro  and
H. Furuya
S. Inoue
Affiliation:
Department of Anesthesiology, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565, Japan
Y. Takauchi
Affiliation:
Department of Anesthesiology, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565, Japan
Y. Kayamori
Affiliation:
Department of Anesthesiology, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565, Japan
M. Kuro
Affiliation:
Department of Anesthesiology, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565, Japan
H. Furuya
Affiliation:
Department of Anesthesiology, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565, Japan
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Abstract

Perioperative myocardial infarction or ischaemia is a potential consequence of cardiac surgery and elevated free fatty acids can increase the severity of myocardial ischaemic damage. We investigated perioperative changes in serum free fatty acids, and other serum lipids, as a consequence of using propofol infusions for cardiac surgery during cardiopulmonary bypass. Twenty-five patients undergoing elective coronary artery bypass grafting were allocated to two groups. One group of 12 patients was given a continuous infusion of propofol and the other group of nine patients received intermittent boluses of midazolam as a hypnotic agent. Serum lipid concentrations were measured at four periods perioperatively. Changes in free fatty acid concentrations were similar between the two groups. Lipid concentrations related to triglyceride in the propofol group decreased on one occasion but subsequently returned to control value. On the other hand, such values in the midazolam group remained lower than control values. Propofol is not a contraindication as an anaesthetic for cardiac surgery in respect of concern regarding the effects of free fatty acids.

Keywords

anaestheticspropofollipidnon-esterified fatty acidextracorporeal circulationcardiopulmonary bypasssurgical specialitiesthoracic surgery
Type
Clinical Letter
Information
European Journal of Anaesthesiology , Volume 18 , Issue 2 , February 2001 , pp. 113 - 117
Copyright
2001 European Society of Anaesthesiology

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